KEGG   PATHWAY: gat03460
Entry
gat03460                    Pathway                                
Name
Fanconi anemia pathway - Gasterosteus aculeatus (three-spined stickleback)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
gat03460  Fanconi anemia pathway
gat03460

Other DBs
GO: 0043240
Organism
Gasterosteus aculeatus (three-spined stickleback) [GN:gat]
Gene
120807638  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
120808350  rev3l; DNA polymerase zeta catalytic subunit isoform X1 [KO:K02350] [EC:2.7.7.7]
120808707  fancf; Fanconi anemia group F protein isoform X1 [KO:K10893]
120808809  fanci; Fanconi anemia group I protein isoform X1 [KO:K10895]
120808854  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
120808927  [KO:K10898]
120808928  faap24; Fanconi anemia core complex-associated protein 24 isoform X1 [KO:K10898]
120809147  [KO:K10888]
120809558  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
120812887  [KO:K10895]
120815987  [KO:K15361]
120816251  [KO:K06054]
120818889  [KO:K10605] [EC:2.3.2.27]
120818909  pms2; LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2 [KO:K10858]
120818910  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
120819266  ercc4; DNA repair endonuclease XPF isoform X1 [KO:K10848] [EC:3.1.-.-]
120819368  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
120819611  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
120820737  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
120820826  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
120820865  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
120821302  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
120821589  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
120822229  [KO:K07466]
120823020  poln; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
120823048  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
120823427  usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 [KO:K11832] [EC:3.4.19.12]
120824322  her6; hairy-related 6 [KO:K06054]
120825137  slx4; structure-specific endonuclease subunit SLX4 [KO:K10484]
120825457  palb2; LOW QUALITY PROTEIN: protein capicua homolog [KO:K10897]
120825482  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
120825599  rpa1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
120826306  rpa3; replication protein A 14 kDa subunit [KO:K10740]
120827414  top3a; LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
120827475  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
120827615  cenpx; centromere protein X [KO:K15360]
120829488  fance; Fanconi anemia group E protein isoform X1 [KO:K10892]
120829600  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
120829746  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
120829800  her9; hairy-related 9 isoform X1 [KO:K06054]
120830131  fancg; Fanconi anemia group G protein isoform X1 [KO:K10894]
120830377  poli; DNA polymerase iota [KO:K03510] [EC:2.7.7.7]
120830530  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
120830707  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
120830899  fancc; Fanconi anemia group C protein [KO:K10890]
120831279  polk; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
120832494  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
120832712  fancm; Fanconi anemia group M protein isoform X1 [KO:K10896]
120833576  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
120833578  rev1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
120833739  fancb; Fanconi anemia group B protein [KO:K10889]
120834960  fancd2; Fanconi anemia group D2 protein isoform X1 [KO:K10891]
120835241  [KO:K10905]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
gat03430  Mismatch repair
gat03440  Homologous recombination
KO pathway
ko03460   

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