KEGG   Homo sapiens (human): 3162
Entry
3162              CDS       T01001                                 

Symbol
HMOX1, HMOX1D, HO-1, HSP32, bK286B10
Name
(RefSeq) heme oxygenase 1
  KO
K00510  heme oxygenase 1 [EC:1.14.14.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00860  Porphyrin metabolism
hsa01100  Metabolic pathways
hsa04066  HIF-1 signaling pathway
hsa04216  Ferroptosis
hsa04978  Mineral absorption
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Disease
H01714  Chronic obstructive pulmonary disease (COPD)
Drug target
Stannsoporfin: D05922
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    3162 (HMOX1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    3162 (HMOX1)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    3162 (HMOX1)
 09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    3162 (HMOX1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3162 (HMOX1)
   05206 MicroRNAs in cancer
    3162 (HMOX1)
   05208 Chemical carcinogenesis - reactive oxygen species
    3162 (HMOX1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    3162 (HMOX1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    3162 (HMOX1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.18  heme oxygenase (biliverdin-producing)
     3162 (HMOX1)
SSDB
Motif
Pfam: Heme_oxygenase REC1
Other DBs
NCBI-GeneID: 3162
NCBI-ProteinID: NP_002124
OMIM: 141250
HGNC: 5013
Ensembl: ENSG00000100292
Vega: OTTHUMG00000150960
Pharos: P09601(Tbio)
UniProt: P09601 Q6FH11
Structure
LinkDB
Position
22:35381096..35394207
AA seq 288 aa
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
NT seq 867 nt   +upstreamnt  +downstreamnt
atggagcgtccgcaacccgacagcatgccccaggatttgtcagaggccctgaaggaggcc
accaaggaggtgcacacccaggcagagaatgctgagttcatgaggaactttcagaagggc
caggtgacccgagacggcttcaagctggtgatggcctccctgtaccacatctatgtggcc
ctggaggaggagattgagcgcaacaaggagagcccagtcttcgcccctgtctacttccca
gaagagctgcaccgcaaggctgccctggagcaggacctggccttctggtacgggccccgc
tggcaggaggtcatcccctacacaccagccatgcagcgctatgtgaagcggctccacgag
gtggggcgcacagagcccgagctgctggtggcccacgcctacacccgctacctgggtgac
ctgtctgggggccaggtgctcaaaaagattgcccagaaagccctggacctgcccagctct
ggcgagggcctggccttcttcaccttccccaacattgccagtgccaccaagttcaagcag
ctctaccgctcccgcatgaactccctggagatgactcccgcagtcaggcagagggtgata
gaagaggccaagactgcgttcctgctcaacatccagctctttgaggagttgcaggagctg
ctgacccatgacaccaaggaccagagcccctcacgggcaccagggcttcgccagcgggcc
agcaacaaagtgcaagattctgcccccgtggagactcccagagggaagcccccactcaac
acccgctcccaggctccgcttctccgatgggtccttacactcagctttctggtggcgaca
gttgctgtagggctttatgccatgtga

KEGG   Homo sapiens (human): 1728
Entry
1728              CDS       T01001                                 

Symbol
NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Name
(RefSeq) NAD(P)H quinone dehydrogenase 1
  KO
K00355  NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05200  Pathways in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Drug target
Acenocoumarol: D07064
Warfarin (DG00149): D00564<US> D01280<JP> D08682
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    1728 (NQO1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1728 (NQO1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1728 (NQO1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    1728 (NQO1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1728 (NQO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.2  NAD(P)H dehydrogenase (quinone)
     1728 (NQO1)
SSDB
Motif
Pfam: Flavodoxin_2 FMN_red
Other DBs
NCBI-GeneID: 1728
NCBI-ProteinID: NP_000894
OMIM: 125860
HGNC: 2874
Ensembl: ENSG00000181019
Vega: OTTHUMG00000137575
Pharos: P15559(Tchem)
UniProt: P15559
Structure
LinkDB
Position
16:complement(69709401..69726560)
AA seq 274 aa
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NT seq 825 nt   +upstreamnt  +downstreamnt
atggtcggcagaagagcactgatcgtactggctcactcagagaggacgtccttcaactat
gccatgaaggaggctgctgcagcggctttgaagaagaaaggatgggaggtggtggagtcg
gacctctatgccatgaacttcaatcccatcatttccagaaaggacatcacaggtaaactg
aaggaccctgcgaactttcagtatcctgccgagtctgttctggcttataaagaaggccat
ctgagcccagatattgtggctgaacaaaagaagctggaagccgcagaccttgtgatattc
cagttccccctgcagtggtttggagtccctgccattctgaaaggctggtttgagcgagtg
ttcataggagagtttgcttacacttacgctgccatgtatgacaaaggacccttccggagt
aagaaggcagtgctttccatcaccactggtggcagtggctccatgtactctctgcaaggg
atccacggggacatgaatgtcattctctggccaattcagagtggcattctgcatttctgt
ggcttccaagtcttagaacctcaactgacatatagcattgggcacactccagcagacgcc
cgaattcaaatcctggaaggatggaagaaacgcctggagaatatttgggatgagacacca
ctgtattttgctccaagcagcctctttgacctaaacttccaggcaggattcttaatgaaa
aaagaggtacaggatgaggagaaaaacaagaaatttggcctttctgtgggccatcacttg
ggcaagtccatcccaactgacaaccagatcaaagctagaaaatga

KEGG   Homo sapiens (human): 10327
Entry
10327             CDS       T01001                                 

Symbol
AKR1A1, ALDR1, ALR, ARM, DD3, HEL-S-6
Name
(RefSeq) aldo-keto reductase family 1 member A1
  KO
K00002  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00040  Pentose and glucuronate interconversions
hsa00053  Ascorbate and aldarate metabolism
hsa00561  Glycerolipid metabolism
hsa00620  Pyruvate metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00014  Glucuronate pathway (uronate pathway)
Network
nt06226  KEAP1-NRF2 signaling
nt06251  CYP-mediated ROS formation
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    10327 (AKR1A1)
   00040 Pentose and glucuronate interconversions
    10327 (AKR1A1)
   00053 Ascorbate and aldarate metabolism
    10327 (AKR1A1)
   00620 Pyruvate metabolism
    10327 (AKR1A1)
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    10327 (AKR1A1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    10327 (AKR1A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10327 (AKR1A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.2  alcohol dehydrogenase (NADP+)
     10327 (AKR1A1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   10327 (AKR1A1)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 10327
NCBI-ProteinID: NP_001189342
OMIM: 103830
HGNC: 380
Ensembl: ENSG00000117448
Vega: OTTHUMG00000007740
Pharos: P14550(Tchem)
UniProt: P14550 V9HWI0
Structure
LinkDB
Position
1:45550779..45570051
AA seq 325 aa
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY
NT seq 978 nt   +upstreamnt  +downstreamnt
atggcggcttcctgtgttctactgcacactgggcagaagatgcctctgattggtctgggt
acctggaagagtgagcctggtcaggtaaaagcagctgttaagtatgcccttagcgtaggc
taccgccacattgattgtgctgctatctacggcaatgagcctgagattggggaggccctg
aaggaggacgtgggaccaggcaaggcggtgcctcgggaggagctgtttgtgacatccaag
ctgtggaacaccaagcaccaccccgaggatgtggagcctgccctccggaagactctggct
gacctccagctggagtatctggacctgtacctgatgcactggccttatgcctttgagcgg
ggagacaaccccttccccaagaatgctgatgggactatatgctacgactccacccactac
aaggagacttggaaggctctggaggcactggtggctaaggggctggtgcaggcgctgggc
ctgtccaacttcaacagtcggcagattgatgacatactcagtgtggcctccgtgcgtcca
gctgtcttgcaggtggaatgccacccatacttggctcaaaatgagctaattgcccactgc
caagcacgtggcctggaggtaactgcttatagccctttgggctcctctgatcgtgcatgg
cgtgatcctgatgagcctgtcctgctggaggaaccagtagtcctggcattggctgaaaag
tatggccgatctccagctcagatcttgctcaggtggcaggtccagcggaaagtgatctgc
atccccaaaagtatcactccttctcgaatccttcagaacatcaaggtgtttgacttcacc
tttagcccagaagagatgaagcagctaaatgccctgaacaaaaattggagatatattgtg
cctatgcttacggtggatgggaagagagtcccaagggatgcagggcatcctctgtacccc
tttaatgacccgtactga

KEGG   Homo sapiens (human): 1109
Entry
1109              CDS       T01001                                 

Symbol
AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Name
(RefSeq) aldo-keto reductase family 1 member C4
  KO
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00120  Primary bile acid biosynthesis
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa05208  Chemical carcinogenesis - reactive oxygen species
Module
hsa_M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Network
nt06022  Bile acid biosynthesis
nt06226  KEAP1-NRF2 signaling
nt06251  CYP-mediated ROS formation
  Element
N00805  Bile acid biosynthesis
N00806  ACOX2 deficiency in bile acid biosynthesis
N00807  AMACR deficiency in bile acid biosynthesis
N00808  CYP27A1 deficiency in bile acid biosynthesis
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    1109 (AKR1C4)
   00140 Steroid hormone biosynthesis
    1109 (AKR1C4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1109 (AKR1C4)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     1109 (AKR1C4)
    1.1.1.225  chlordecone reductase
     1109 (AKR1C4)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     1109 (AKR1C4)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 1109
NCBI-ProteinID: NP_001809
OMIM: 600451
HGNC: 387
Ensembl: ENSG00000198610
Vega: OTTHUMG00000017591
Pharos: P17516(Tbio)
UniProt: P17516
Structure
LinkDB
Position
10:5196837..5218949
AA seq 323 aa
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggatcccaaatatcagcgtgtagagctaaatgatggtcacttcatgcccgtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtagaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctcaagccaggtgagacgccactaccaaaagatgaaaatggaaaagtaatattcgac
acagtggatctctctgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtcaaacttcaactgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgttctggttgcccacagtgctctggga
acccaacgacataaactatgggtggacccaaactccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaaacacaaacaaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaac
atccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggtctaaac
agaaattatcgatatgttgtcatggattttcttatggaccatcctgattatccattttca
gatgaatattag

KEGG   Homo sapiens (human): 1645
Entry
1645              CDS       T01001                                 

Symbol
AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Name
(RefSeq) aldo-keto reductase family 1 member C1
  KO
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06226  KEAP1-NRF2 signaling
nt06251  CYP-mediated ROS formation
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1645 (AKR1C1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1645 (AKR1C1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1645 (AKR1C1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     1645 (AKR1C1)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     1645 (AKR1C1)
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.20  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
     1645 (AKR1C1)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 1645
NCBI-ProteinID: NP_001344
OMIM: 600449
HGNC: 384
Ensembl: ENSG00000187134
Vega: OTTHUMG00000017580
Pharos: Q04828(Tchem)
UniProt: Q04828
Structure
LinkDB
Position
10:4963415..4983283
AA seq 323 aa
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcgaaatatcagtgtgtgaagctgaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcgcctgcagaggttcctaaaagtaaagctttagaggccaccaaattg
gcaattgaagctggcttccgccatattgattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcaattcccatcgaccagagttggtccgaccagccttggaa
aggtcactgaaaaatcttcaattggattatgttgacctctaccttattcattttccagtg
tctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgac
acagtggatctctgtgccacatgggaggccgtggagaagtgtaaagatgcaggattggcc
aagtccatcggggtgtccaacttcaaccgcaggcagctggagatgatcctcaacaagcca
gggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagaga
aaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctggga
tcccaccgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctacagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaac
agaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttct
gatgaatattaa

KEGG   Homo sapiens (human): 1646
Entry
1646              CDS       T01001                                 

Symbol
AKR1C2, AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Name
(RefSeq) aldo-keto reductase family 1 member C2
  KO
K00089  3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06226  KEAP1-NRF2 signaling
nt06250  DNA adduct formation
nt06251  CYP-mediated ROS formation
  Element
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1646 (AKR1C2)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1646 (AKR1C2)
   05208 Chemical carcinogenesis - reactive oxygen species
    1646 (AKR1C2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     1646 (AKR1C2)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     1646 (AKR1C2)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 1646
NCBI-ProteinID: NP_001345
OMIM: 600450
HGNC: 385
Ensembl: ENSG00000151632
Vega: OTTHUMG00000017584
Pharos: P52895(Tchem)
UniProt: P52895
Structure
LinkDB
Position
10:complement(4987775..5018000)
AA seq 323 aa
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcgaaataccagtgtgtgaagctgaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcgcctgcagaggttcctaaaagtaaagctctagaggccgtcaaattg
gcaatagaagccgggttccaccatattgattctgcacatgtttacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggagcaattcccatcgaccagagttggtccgaccagccttggaa
aggtcactgaaaaatcttcaattggactatgttgacctctatcttattcattttccagtg
tctgtaaagccaggtgaggaagtgatcccaaaagatgaaaatggaaaaatactatttgac
acagtggatctctgtgccacatgggaggccatggagaagtgtaaagatgcaggattggcc
aagtccatcggggtgtccaacttcaaccacaggctgctggagatgatcctcaacaagcca
gggctcaagtacaagcctgtctgcaaccaggtggaatgtcatccttacttcaaccagaga
aaactgctggatttctgcaagtcaaaagacattgttctggttgcctatagtgctctggga
tcccatcgagaagaaccatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtgtttgaattccagttgacttcagaggagatgaaagccatagatggcctaaac
agaaatgtgcgatatttgacccttgatatttttgctggcccccctaattatccattttct
gatgaatattaa

KEGG   Homo sapiens (human): 8644
Entry
8644              CDS       T01001                                 

Symbol
AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
Name
(RefSeq) aldo-keto reductase family 1 member C3
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06226  KEAP1-NRF2 signaling
nt06251  CYP-mediated ROS formation
  Element
N01401  Benzo[a]pyrenre to CYP-mediated metabolism
N01413  Metals to KEAP1-NRF2 signalig pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    8644 (AKR1C3)
   00590 Arachidonic acid metabolism
    8644 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    8644 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    8644 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    8644 (AKR1C3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     8644 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     8644 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     8644 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     8644 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 8644
NCBI-ProteinID: NP_001240837
OMIM: 603966
HGNC: 386
Ensembl: ENSG00000196139
Vega: OTTHUMG00000017585
Pharos: P42330(Tchem)
UniProt: P42330 A0A0A0MSS8
Structure
LinkDB
Position
10:5048781..5107686
AA seq 323 aa
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattcaaaacatcagtgtttgaagctaaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtccacttttcatcgaccagagttggtccgaccagccttggaa
aactcactgaagaaagctcaattggactatgttgacctctatcttattcattctccaatg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcgaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccactattttaacagtgatagttttgctagccaccctaattatccatattca
gatgaatattaa

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