Homo sapiens (human): 3455
Help
Entry
3455 CDS
T01001
Symbol
IFNAR2, IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Name
(RefSeq) interferon alpha and beta receptor subunit 2
KO
K05131
interferon receptor 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04217
Necroptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa05160
Hepatitis C
hsa05162
Measles
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06219
JAK-STAT signaling (cancer)
nt06222
IFN signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
nt06527
Necroptosis
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00150
Type I IFN signaling pathway
N00471
EBV LMP2A/2B to IFN signaling pathway
N01558
Type I interferon to Jak-STAT signaling pathway
N01560
Regulation of type I interferon to Jak-STAT signaling pathway, USP18
N01662
IFN-RIPK1/3 signaling pathway
Disease
H00412
Hepatitis B
H02525
Disorders of innate immunity
Drug target
Albinterferon alfa-2b:
D08844
Anifrolumab:
D11082
<JP/US>
Interferon alfa natural:
D03305
<JP>
Interferon alfa-2a:
D00745
Interferon alfa-2b:
D02745
Interferon alfa-n1:
D04552
Interferon alfacon-1:
D02744
Interferon alpha
(abbr) INFalpha (
DG01750
):
D04553
Interferon beta natural:
D03304
Interferon beta-1a:
D04554
<JP/US>
Interferon beta-1b:
D00746
<JP/US>
Peginterferon alfa-2a:
D02747
<JP/US>
Peginterferon alfa-2b:
D02748
Peginterferon beta-1a:
D10483
<US>
Ropeginterferon alfa-2b:
D11027
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3455 (IFNAR2)
04151 PI3K-Akt signaling pathway
3455 (IFNAR2)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3455 (IFNAR2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
3455 (IFNAR2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3455 (IFNAR2)
04621 NOD-like receptor signaling pathway
3455 (IFNAR2)
04650 Natural killer cell mediated cytotoxicity
3455 (IFNAR2)
09158 Development and regeneration
04380 Osteoclast differentiation
3455 (IFNAR2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3455 (IFNAR2)
09172 Infectious disease: viral
05160 Hepatitis C
3455 (IFNAR2)
05171 Coronavirus disease - COVID-19
3455 (IFNAR2)
05164 Influenza A
3455 (IFNAR2)
05162 Measles
3455 (IFNAR2)
05168 Herpes simplex virus 1 infection
3455 (IFNAR2)
05167 Kaposi sarcoma-associated herpesvirus infection
3455 (IFNAR2)
05169 Epstein-Barr virus infection
3455 (IFNAR2)
05165 Human papillomavirus infection
3455 (IFNAR2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
3455 (IFNAR2)
Cytokine receptors [BR:
hsa04050
]
Interleukin receptor families
IFN receptor family
3455 (IFNAR2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Tissue_fac
Interfer-bind
Motif
Other DBs
NCBI-GeneID:
3455
NCBI-ProteinID:
NP_001276054
OMIM:
602376
HGNC:
5433
Ensembl:
ENSG00000159110
UniProt:
P48551
Structure
PDB
PDBj
LinkDB
All DBs
Position
21:33229938..33265664
Genome browser
AA seq
515 aa
AA seq
DB search
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHS
IVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLF
SCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKK
HKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAE
SAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMD
MVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLI
DPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGR
ITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPT
FPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
NT seq
1548 nt
NT seq
+upstream
nt +downstream
nt
atgcttttgagccagaatgccttcatcttcagatcacttaatttggttctcatggtgtat
atcagcctcgtgtttggtatttcatatgattcgcctgattacacagatgaatcttgcact
ttcaagatatcattgcgaaatttccggtccatcttatcatgggaattaaaaaaccactcc
attgtaccaactcactatacattgctgtatacaatcatgagtaaaccagaagatttgaag
gtggttaagaactgtgcaaataccacaagatcattttgtgacctcacagatgagtggaga
agcacacacgaggcctatgtcaccgtcctagaaggattcagcgggaacacaacgttgttc
agttgctcacacaatttctggctggccatagacatgtcttttgaaccaccagagtttgag
attgttggttttaccaaccacattaatgtgatggtgaaatttccatctattgttgaggaa
gaattacagtttgatttatctctcgtcattgaagaacagtcagagggaattgttaagaag
cataaacccgaaataaaaggaaacatgagtggaaatttcacctatatcattgacaagtta
attccaaacacgaactactgtgtatctgtttatttagagcacagtgatgagcaagcagta
ataaagtctcccttaaaatgcaccctccttccacctggccaggaatcagaatcagcagaa
tctgccaaaataggaggaataattactgtgtttttgatagcattggtcttgacaagcacc
atagtgacactgaaatggattggttatatatgcttaagaaatagcctccccaaagtcttg
aattttcataactttttagcctggccatttcctaacctgccaccgttggaagccatggat
atggtggaggtcatttacatcaacagaaagaagaaagtgtgggattataattatgatgat
gaaagtgatagcgatactgaggcagcgcccaggacaagtggcggtggctataccatgcat
ggactgactgtcaggcctctgggtcaggcctctgccacctctacagaatcccagttgata
gacccggagtccgaggaggagcctgacctgcctgaggttgatgtggagctccccacgatg
ccaaaggacagccctcagcagttggaactcttgagtgggccctgtgagaggagaaagagt
ccactccaggacccttttcccgaagaggactacagctccacggaggggtctgggggcaga
attaccttcaatgtggacttaaactctgtgtttttgagagttcttgatgacgaggacagt
gacgacttagaagcccctctgatgctatcgtctcatctggaagagatggttgacccagag
gatcctgataatgtgcaatcaaaccatttgctggccagcggggaagggacacagccaacc
tttcccagcccctcttcagagggcctgtggtccgaagatgctccatctgatcaaagtgac
acttctgagtcagatgttgaccttggggatggttatataatgagatga
Homo sapiens (human): 6773
Help
Entry
6773 CDS
T01001
Symbol
STAT2, IMD44, ISGF-3, P113, PTORCH3, STAT113
Name
(RefSeq) signal transducer and activator of transcription 2
KO
K11221
signal transducer and activator of transcription 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04217
Necroptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06219
JAK-STAT signaling (cancer)
nt06222
IFN signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06517
TLR signaling
nt06518
JAK-STAT signaling
nt06527
Necroptosis
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00150
Type I IFN signaling pathway
N00261
KSHV vIRF2 to IFN signaling pathway
N00270
HCV Core to IFN signaling pathway
N00378
HPV E6 to IFN signaling pathway
N00379
HPV E7 to IFN signaling pathway
N00473
EBV BGLF4 to IFN signaling pathway
N00558
HBV pol to IFN signaling pathway
N00575
HSV ICP27 to IFN signaling pathway
N00578
HSV UL41 to IFN signaling pathway
N00694
MV V/P/C to IFN signaling pathway
N00738
IAV NS1 to IFN signaling pathway
N01322
SARS-CoV-2 nsp6/13 and ORF7a/7b to IFN signaling pathway
N01558
Type I interferon to Jak-STAT signaling pathway
N01560
Regulation of type I interferon to Jak-STAT signaling pathway, USP18
N01662
IFN-RIPK1/3 signaling pathway
Disease
H00840
Pseudo-TORCH syndrome
H02525
Disorders of innate immunity
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
6773 (STAT2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
6773 (STAT2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
6773 (STAT2)
04621 NOD-like receptor signaling pathway
6773 (STAT2)
04625 C-type lectin receptor signaling pathway
6773 (STAT2)
04062 Chemokine signaling pathway
6773 (STAT2)
09158 Development and regeneration
04380 Osteoclast differentiation
6773 (STAT2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6773 (STAT2)
09172 Infectious disease: viral
05161 Hepatitis B
6773 (STAT2)
05160 Hepatitis C
6773 (STAT2)
05171 Coronavirus disease - COVID-19
6773 (STAT2)
05164 Influenza A
6773 (STAT2)
05162 Measles
6773 (STAT2)
05168 Herpes simplex virus 1 infection
6773 (STAT2)
05167 Kaposi sarcoma-associated herpesvirus infection
6773 (STAT2)
05169 Epstein-Barr virus infection
6773 (STAT2)
05165 Human papillomavirus infection
6773 (STAT2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
6773 (STAT2)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
STAT
6773 (STAT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
STAT_alpha
STAT2_C
STAT_bind
STAT_int
STAT_linker
SH2
CorA
Tex_N
Motif
Other DBs
NCBI-GeneID:
6773
NCBI-ProteinID:
NP_005410
OMIM:
600556
HGNC:
11363
Ensembl:
ENSG00000170581
UniProt:
P52630
R9QE65
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:complement(56341597..56360107)
Genome browser
AA seq
851 aa
AA seq
DB search
MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF
FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILI
QAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQ
AKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKA
QQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLR
NAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVE
VSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKG
PLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQ
NQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWAD
FTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLL
RFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENP
LRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELES
LELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQG
PVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHF
YTDGPLMPSDF
NT seq
2556 nt
NT seq
+upstream
nt +downstream
nt
atggcgcagtgggaaatgctgcagaatcttgacagcccctttcaggatcagctgcaccag
ctttactcgcacagcctcctgcctgtggacattcgacagtacttggctgtctggattgaa
gaccagaactggcaggaagctgcacttgggagtgatgattccaaggctaccatgctattc
ttccacttcttggatcagctgaactatgagtgtggccgttgcagccaggacccagagtcc
ttgttgctgcagcacaatttgcggaaattctgccgggacattcagcccttttcccaggat
cctacccagttggctgagatgatctttaacctccttctggaagaaaaaagaattttgatc
caggctcagagggcccaattggaacaaggagagccagttctcgaaacacctgtggagagc
cagcaacatgagattgaatcccggatcctggatttaagggctatgatggagaagctggta
aaatccatcagccaactgaaagaccagcaggatgtcttctgcttccgatataagatccag
gccaaagggaagacaccctctctggacccccatcagaccaaagagcagaagattctgcag
gaaactctcaatgaactggacaaaaggagaaaggaggtgctggatgcctccaaagcactg
ctaggccgattaactaccctaatcgagctactgctgccaaagttggaggagtggaaggcc
cagcagcaaaaagcctgcatcagagctcccattgaccacgggttggaacagctggagaca
tggttcacagctggagcaaagctgttgtttcacctgaggcagctgctgaaggagctgaag
ggactgagttgcctggttagctatcaggatgaccctctgaccaaaggggtggacctacgc
aacgcccaggtcacagagttgctacagcgtctgctccacagagcctttgtggtagaaacc
cagccctgcatgccccaaactccccatcgacccctcatcctcaagactggcagcaagttc
accgtccgaacaaggctgctggtgagactccaggaaggcaatgagtcactgactgtggaa
gtctccattgacaggaatcctcctcaattacaaggcttccggaagttcaacattctgact
tcaaaccagaaaactttgacccccgagaaggggcagagtcagggtttgatttgggacttt
ggttacctgactctggtggagcaacgttcaggtggttcaggaaagggcagcaataagggg
ccactaggtgtgacagaggaactgcacatcatcagcttcacggtcaaatatacctaccag
ggtctgaagcaggagctgaaaacggacaccctccctgtggtgattatttccaacatgaac
cagctctcaattgcctgggcttcagttctctggttcaatttgctcagcccaaaccttcag
aaccagcagttcttctccaacccccccaaggccccctggagcttgctgggccctgctctc
agttggcagttctcctcctatgttggccgaggcctcaactcagaccagctgagcatgctg
agaaacaagctgttcgggcagaactgtaggactgaggatccattattgtcctgggctgac
ttcactaagcgagagagccctcctggcaagttaccattctggacatggctggacaaaatt
ctggagttggtacatgaccacctgaaggatctctggaatgatggacgcatcatgggcttt
gtgagtcggagccaggagcgccggctgctgaagaagaccatgtctggcacctttctactg
cgcttcagtgaatcgtcagaagggggcattacctgctcctgggtggagcaccaggatgat
gacaaggtgctcatctactctgtgcaaccgtacacgaaggaggtgctgcagtcactcccg
ctgactgaaatcatccgccattaccagttgctcactgaggagaatatacctgaaaaccca
ctgcgcttcctctatccccgaatcccccgggatgaagcttttgggtgctactaccaggag
aaagttaatctccaggaacggaggaaatacctgaaacacaggctcattgtggtctctaat
agacaggtggatgaactgcaacaaccgctggagcttaagccagagccagagctggagtca
ttagagctggaactagggctggtgccagagccagagctcagcctggacttagagccactg
ctgaaggcagggctggatctggggccagagctagagtctgtgctggagtccactctggag
cctgtgatagagcccacactatgcatggtatcacaaacagtgccagagccagaccaagga
cctgtatcacagccagtgccagagccagatttgccctgtgatctgagacatttgaacact
gagccaatggaaatcttcagaaactgtgtaaagattgaagaaatcatgccgaatggtgac
ccactgttggctggccagaacaccgtggatgaggtttacgtctcccgccccagccacttc
tacactgatggacccttgatgccttctgacttctag
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integrated database retrieval system
