Homo sapiens (human): 596
Help
Entry
596 CDS
T01001
Symbol
BCL2, Bcl-2, PPP1R50
Name
(RefSeq) BCL2 apoptosis regulator
KO
K02161
apoptosis regulator Bcl-2
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04064
NF-kappa B signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04115
p53 signaling pathway
hsa04140
Autophagy - animal
hsa04141
Protein processing in endoplasmic reticulum
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04217
Necroptosis
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04340
Hedgehog signaling pathway
hsa04510
Focal adhesion
hsa04621
NOD-like receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04725
Cholinergic synapse
hsa04915
Estrogen signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05210
Colorectal cancer
hsa05215
Prostate cancer
hsa05222
Small cell lung cancer
hsa05226
Gastric cancer
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06210
ERK signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06231
Apoptosis (cancer)
nt06260
Colorectal cancer
nt06267
Small cell lung cancer
nt06270
Breast cancer
nt06323
KISS1-GnRH-LH/FSH-E2 signaling
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
Element
N00098
Intrinsic apoptotic pathway
N00100
BCL2-overexpression to intrinsic apoptotic pathway
N00286
Nuclear-initiated estrogen signaling pathway
N00451
HIV Tat to intrinsic apoptotic pathway
N00453
HIV Vpr to intrinsic apoptotic pathway
N00475
EBV BHRF1 to intrinsic apoptotic pathway
N00478
EBV BARF1 to intrinsic apoptotic pathway
N01135
Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01344
NNK/NNN to RAS-ERK signaling pathway
Disease
H00005
Chronic lymphocytic leukemia
H00013
Small cell lung cancer
H00028
Choriocarcinoma
H00030
Cervical cancer
H00041
Kaposi sarcoma
H00054
Nasopharyngeal cancer
H01613
Follicular lymphoma
H02434
Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Obatoclax mesylate:
D08954
Oblimersen (
DG00728
):
D05216
D08290
Sonrotoclax:
D12883
Surzetoclax:
D13082
Venetoclax:
D10679
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
596 (BCL2)
09130 Environmental Information Processing
09132 Signal transduction
04340 Hedgehog signaling pathway
596 (BCL2)
04630 JAK-STAT signaling pathway
596 (BCL2)
04064 NF-kappa B signaling pathway
596 (BCL2)
04066 HIF-1 signaling pathway
596 (BCL2)
04071 Sphingolipid signaling pathway
596 (BCL2)
04151 PI3K-Akt signaling pathway
596 (BCL2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
596 (BCL2)
09143 Cell growth and death
04210 Apoptosis
596 (BCL2)
04215 Apoptosis - multiple species
596 (BCL2)
04217 Necroptosis
596 (BCL2)
04115 p53 signaling pathway
596 (BCL2)
09144 Cellular community - eukaryotes
04510 Focal adhesion
596 (BCL2)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
596 (BCL2)
09152 Endocrine system
04915 Estrogen signaling pathway
596 (BCL2)
04928 Parathyroid hormone synthesis, secretion and action
596 (BCL2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
596 (BCL2)
09156 Nervous system
04725 Cholinergic synapse
596 (BCL2)
04722 Neurotrophin signaling pathway
596 (BCL2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
596 (BCL2)
05206 MicroRNAs in cancer
596 (BCL2)
05207 Chemical carcinogenesis - receptor activation
596 (BCL2)
09162 Cancer: specific types
05210 Colorectal cancer
596 (BCL2)
05226 Gastric cancer
596 (BCL2)
05215 Prostate cancer
596 (BCL2)
05222 Small cell lung cancer
596 (BCL2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
596 (BCL2)
05161 Hepatitis B
596 (BCL2)
05162 Measles
596 (BCL2)
05168 Herpes simplex virus 1 infection
596 (BCL2)
05169 Epstein-Barr virus infection
596 (BCL2)
09171 Infectious disease: bacterial
05132 Salmonella infection
596 (BCL2)
05131 Shigellosis
596 (BCL2)
05152 Tuberculosis
596 (BCL2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
596 (BCL2)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
596 (BCL2)
05022 Pathways of neurodegeneration - multiple diseases
596 (BCL2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
596 (BCL2)
05418 Fluid shear stress and atherosclerosis
596 (BCL2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
596 (BCL2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
596 (BCL2)
01524 Platinum drug resistance
596 (BCL2)
01522 Endocrine resistance
596 (BCL2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
596 (BCL2)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
596 (BCL2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Bcl-2
BH4
Bcl-2_3
ARMH5
Motif
Other DBs
NCBI-GeneID:
596
NCBI-ProteinID:
NP_000624
OMIM:
151430
HGNC:
990
Ensembl:
ENSG00000171791
UniProt:
P10415
Structure
PDB
PDBj
LinkDB
All DBs
Position
18:complement(63123346..63320090)
Genome browser
AA seq
239 aa
AA seq
DB search
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
NT seq
720 nt
NT seq
+upstream
nt +downstream
nt
atggcgcacgctgggagaacagggtacgataaccgggagatagtgatgaagtacatccat
tataagctgtcgcagaggggctacgagtgggatgcgggagatgtgggcgccgcgcccccg
ggggccgcccccgcaccgggcatcttctcctcccagcccgggcacacgccccatccagcc
gcatcccgggacccggtcgccaggacctcgccgctgcagaccccggctgcccccggcgcc
gccgcggggcctgcgctcagcccggtgccacctgtggtccacctgaccctccgccaggcc
ggcgacgacttctcccgccgctaccgccgcgacttcgccgagatgtccagccagctgcac
ctgacgcccttcaccgcgcggggacgctttgccacggtggtggaggagctcttcagggac
ggggtgaactgggggaggattgtggccttctttgagttcggtggggtcatgtgtgtggag
agcgtcaaccgggagatgtcgcccctggtggacaacatcgccctgtggatgactgagtac
ctgaaccggcacctgcacacctggatccaggataacggaggctgggatgcctttgtggaa
ctgtacggccccagcatgcggcctctgtttgatttctcctggctgtctctgaagactctg
ctcagtttggccctggtgggagcttgcatcaccctgggtgcctatctgggccacaagtga
Homo sapiens (human): 598
Help
Entry
598 CDS
T01001
Symbol
BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
Name
(RefSeq) BCL2 like 1
KO
K04570
Bcl-2-like 1 (apoptosis regulator Bcl-X)
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01524
Platinum drug resistance
hsa04014
Ras signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04115
p53 signaling pathway
hsa04137
Mitophagy - animal
hsa04140
Autophagy - animal
hsa04151
PI3K-Akt signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa04621
NOD-like receptor signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
hsa05145
Toxoplasmosis
hsa05162
Measles
hsa05166
Human T-cell leukemia virus 1 infection
hsa05168
Herpes simplex virus 1 infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05222
Small cell lung cancer
hsa05225
Hepatocellular carcinoma
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06219
JAK-STAT signaling (cancer)
nt06231
Apoptosis (cancer)
nt06240
Transcription (cancer)
nt06260
Colorectal cancer
nt06267
Small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
Element
N00055
BCR-ABL fusion kinase to Jak-STAT signaling pathway
N00098
Intrinsic apoptotic pathway
N00123
Amplified REL to transcription
N00451
HIV Tat to intrinsic apoptotic pathway
N01051
Mutation-inactivated DJ1 to intrinsic apoptotic pathway
Drug target
Navitoclax (
DG03204
):
D09935
D09936
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
598 (BCL2L1)
04630 JAK-STAT signaling pathway
598 (BCL2L1)
04064 NF-kappa B signaling pathway
598 (BCL2L1)
04151 PI3K-Akt signaling pathway
598 (BCL2L1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
598 (BCL2L1)
04137 Mitophagy - animal
598 (BCL2L1)
09143 Cell growth and death
04210 Apoptosis
598 (BCL2L1)
04215 Apoptosis - multiple species
598 (BCL2L1)
04115 p53 signaling pathway
598 (BCL2L1)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
598 (BCL2L1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
598 (BCL2L1)
05202 Transcriptional misregulation in cancer
598 (BCL2L1)
09162 Cancer: specific types
05212 Pancreatic cancer
598 (BCL2L1)
05225 Hepatocellular carcinoma
598 (BCL2L1)
05220 Chronic myeloid leukemia
598 (BCL2L1)
05222 Small cell lung cancer
598 (BCL2L1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
598 (BCL2L1)
05170 Human immunodeficiency virus 1 infection
598 (BCL2L1)
05162 Measles
598 (BCL2L1)
05168 Herpes simplex virus 1 infection
598 (BCL2L1)
09171 Infectious disease: bacterial
05131 Shigellosis
598 (BCL2L1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
598 (BCL2L1)
09164 Neurodegenerative disease
05012 Parkinson disease
598 (BCL2L1)
05014 Amyotrophic lateral sclerosis
598 (BCL2L1)
05022 Pathways of neurodegeneration - multiple diseases
598 (BCL2L1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
598 (BCL2L1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
598 (BCL2L1)
01524 Platinum drug resistance
598 (BCL2L1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
598 (BCL2L1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
598 (BCL2L1)
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
598 (BCL2L1)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
598 (BCL2L1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centrosome formation proteins
Other centrosome associated proteins
598 (BCL2L1)
Transporters [BR:
hsa02000
]
Other transporters
Pores ion channels [TC:
1
]
598 (BCL2L1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Bcl-2
BH4
Bcl-2_3
Motif
Other DBs
NCBI-GeneID:
598
NCBI-ProteinID:
NP_001304848
OMIM:
600039
HGNC:
992
Ensembl:
ENSG00000171552
UniProt:
Q07817
A0A0S2Z3C5
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:complement(31664452..31723963)
Genome browser
AA seq
233 aa
AA seq
DB search
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
NT seq
702 nt
NT seq
+upstream
nt +downstream
nt
atgtctcagagcaaccgggagctggtggttgactttctctcctacaagctttcccagaaa
ggatacagctggagtcagtttagtgatgtggaagagaacaggactgaggccccagaaggg
actgaatcggagatggagacccccagtgccatcaatggcaacccatcctggcacctggca
gacagccccgcggtgaatggagccactggccacagcagcagtttggatgcccgggaggtg
atccccatggcagcagtaaagcaagcgctgagggaggcaggcgacgagtttgaactgcgg
taccggcgggcattcagtgacctgacatcccagctccacatcaccccagggacagcatat
cagagctttgaacaggtagtgaatgaactcttccgggatggggtaaactggggtcgcatt
gtggcctttttctccttcggcggggcactgtgcgtggaaagcgtagacaaggagatgcag
gtattggtgagtcggatcgcagcttggatggccacttacctgaatgaccacctagagcct
tggatccaggagaacggcggctgggatacttttgtggaactctatgggaacaatgcagca
gccgagagccgaaagggccaggaacgcttcaaccgctggttcctgacgggcatgactgtg
gccggcgtggttctgctgggctcactcttcagtcggaaatga
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integrated database retrieval system
