Homo sapiens (human): 894
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Entry
894 CDS
T01001
Symbol
CCND2, KIAK0002, MPPH3
Name
(RefSeq) cyclin D2
KO
K10151
G1/S-specific cyclin-D2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04115
p53 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04310
Wnt signaling pathway
hsa04340
Hedgehog signaling pathway
hsa04390
Hippo signaling pathway
hsa04510
Focal adhesion
hsa04630
JAK-STAT signaling pathway
hsa04917
Prolactin signaling pathway
hsa05162
Measles
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05206
MicroRNAs in cancer
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06230
Cell cycle (cancer)
nt06240
Transcription (cancer)
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06267
Small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06273
Glioma
nt06276
Chronic myeloid leukemia
Element
N00066
MDM2-p21-Cell cycle G1/S
N00067
Deleted p14(ARF) to p21-cell cycle G1/S
N00068
Amplified MDM2 to p21-cell cycle G1/S
N00069
p16-Cell cycle G1/S
N00070
Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071
Deleted p16(INK4a) to p16-cell cycle G1/S
N00072
Amplified CDK4 to cell cycle G1/S
N00073
Mutation-activated CDK4 to cell cycle G1/S
N00076
Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088
Amplified MYC to p15-cell cycle G1/S
N00089
Amplified MYC to cell cycle G1/S
N00090
p15-Cell cycle G1/S
N00123
Amplified REL to transcription
N00124
IGH-MAF fusion to transcriptional activation
N00125
IGH-MMSET fusion to transcriptional activation
N00347
p300-p21-Cell cycle G1/S
N00483
EBV EBNA3C to cell cycle G1/S
N00489
HTLV-1 p30II to c-myc-mediated transcription
Disease
H00023
Testicular cancer
H01885
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
894 (CCND2)
04340 Hedgehog signaling pathway
894 (CCND2)
04390 Hippo signaling pathway
894 (CCND2)
04630 JAK-STAT signaling pathway
894 (CCND2)
04068 FoxO signaling pathway
894 (CCND2)
04151 PI3K-Akt signaling pathway
894 (CCND2)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
894 (CCND2)
04115 p53 signaling pathway
894 (CCND2)
04218 Cellular senescence
894 (CCND2)
09144 Cellular community - eukaryotes
04510 Focal adhesion
894 (CCND2)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
894 (CCND2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
894 (CCND2)
05202 Transcriptional misregulation in cancer
894 (CCND2)
05206 MicroRNAs in cancer
894 (CCND2)
05203 Viral carcinogenesis
894 (CCND2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
894 (CCND2)
05162 Measles
894 (CCND2)
05169 Epstein-Barr virus infection
894 (CCND2)
05165 Human papillomavirus infection
894 (CCND2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cyclin_N
Cyclin_C
K-cyclin_vir_C
Motif
Other DBs
NCBI-GeneID:
894
NCBI-ProteinID:
NP_001750
OMIM:
123833
HGNC:
1583
Ensembl:
ENSG00000118971
UniProt:
P30279
Structure
PDB
LinkDB
All DBs
Position
12:4273762..4305353
Genome browser
AA seq
289 aa
AA seq
DB search
MELLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVA
TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTA
EKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIRKH
AQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDV
DCLKACQEQIEAVLLNSLQQYRQDQRDGSKSEDELDQASTPTDVRDIDL
NT seq
870 nt
NT seq
+upstream
nt +downstream
nt
atggagctgctgtgccacgaggtggacccggtccgcagggccgtgcgggaccgcaacctg
ctccgagacgaccgcgtcctgcagaacctgctcaccatcgaggagcgctaccttccgcag
tgctcctacttcaagtgcgtgcagaaggacatccaaccctacatgcgcagaatggtggcc
acctggatgctggaggtctgtgaggaacagaagtgcgaagaagaggtcttccctctggcc
atgaattacctggaccgtttcttggctggggtcccgactccgaagtcccatctgcaactc
ctgggtgctgtctgcatgttcctggcctccaaactcaaagagaccagcccgctgaccgcg
gagaagctgtgcatttacaccgacaactccatcaagcctcaggagctgctggagtgggaa
ctggtggtgctggggaagttgaagtggaacctggcagctgtcactcctcatgacttcatt
gagcacatcttgcgcaagctgccccagcagcgggagaagctgtctctgatccgcaagcat
gctcagaccttcattgctctgtgtgccaccgactttaagtttgccatgtacccaccgtcg
atgatcgcaactggaagtgtgggagcagccatctgtgggctccagcaggatgaggaagtg
agctcgctcacttgtgatgccctgactgagctgctggctaagatcaccaacacagacgtg
gattgtctcaaagcttgccaggagcagattgaggcggtgctcctcaatagcctgcagcag
taccgtcaggaccaacgtgacggatccaagtcggaggatgaactggaccaagccagcacc
cctacagacgtgcgggatatcgacctgtga
Homo sapiens (human): 3695
Help
Entry
3695 CDS
T01001
Symbol
ITGB7
Name
(RefSeq) integrin subunit beta 7
KO
K06590
integrin beta 7
Organism
hsa
Homo sapiens (human)
Pathway
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04512
ECM-receptor interaction
hsa04514
Cell adhesion molecules
hsa04672
Intestinal immune network for IgA production
hsa04810
Regulation of actin cytoskeleton
hsa04820
Cytoskeleton in muscle cells
hsa05165
Human papillomavirus infection
hsa05202
Transcriptional misregulation in cancer
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06240
Transcription (cancer)
Element
N00124
IGH-MAF fusion to transcriptional activation
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00951
ITGA/B-RHOG-RAC signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01072
ITGA/B-RhoGEF-RhoA signaling pathway
N01080
ITGA/B-TALIN/VINCULIN signaling pathway
Drug target
Abrilumab:
D10540
Carotegrast methyl:
D09799
<JP>
Etrolizumab:
D09901
Valategrast hydrochloride:
D10028
Vedolizumab:
D08083
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
3695 (ITGB7)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
3695 (ITGB7)
04514 Cell adhesion molecules
3695 (ITGB7)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
3695 (ITGB7)
09142 Cell motility
04820 Cytoskeleton in muscle cells
3695 (ITGB7)
04810 Regulation of actin cytoskeleton
3695 (ITGB7)
09150 Organismal Systems
09151 Immune system
04672 Intestinal immune network for IgA production
3695 (ITGB7)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
3695 (ITGB7)
09172 Infectious disease: viral
05165 Human papillomavirus infection
3695 (ITGB7)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3695 (ITGB7)
05412 Arrhythmogenic right ventricular cardiomyopathy
3695 (ITGB7)
05414 Dilated cardiomyopathy
3695 (ITGB7)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3695 (ITGB7)
04515 Cell adhesion molecules [BR:
hsa04515
]
3695 (ITGB7)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3695 (ITGB7)
Cell adhesion molecules [BR:
hsa04515
]
Integrins
Integrin beta subunits
3695 (ITGB7)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Integrin_beta
Integrin_b_cyt
PSI_integrin
EGF_2
I-EGF_1
Motif
Other DBs
NCBI-GeneID:
3695
NCBI-ProteinID:
NP_000880
OMIM:
147559
HGNC:
6162
Ensembl:
ENSG00000139626
UniProt:
P26010
Structure
PDB
LinkDB
All DBs
Position
12:complement(53191323..53207251)
Genome browser
AA seq
798 aa
AA seq
DB search
MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPS
CAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGA
TQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLV
RLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQ
AFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKL
GGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELS
KLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREG
KAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSD
TQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGK
GHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSG
DMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTG
PLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKG
ADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKS
AITTTINPRFQEADSPTL
NT seq
2397 nt
NT seq
+upstream
nt +downstream
nt
atggtggctttgccaatggtccttgttttgctgctggtcctgagcagaggtgagagtgaa
ttggacgccaagatcccatccacaggggatgccacagaatggcggaatcctcacctgtcc
atgctggggtcctgccagccagccccctcctgccagaagtgcatcctctcacaccccagc
tgtgcatggtgcaagcaactgaacttcaccgcgtcgggagaggcggaggcgcggcgctgc
gcccgacgagaggagctgctggctcgaggctgcccgctggaggagctggaggagccccgc
ggccagcaggaggtgctgcaggaccagccgctcagccagggcgcccgcggagagggtgcc
acccagctggcgccgcagcgggtccgggtcacgctgcggcctggggagccccagcagctc
caggtccgcttccttcgtgctgagggatacccggtggacctgtactaccttatggacctg
agctactccatgaaggacgacctggaacgcgtgcgccagctcgggcacgctctgctggtc
cggctgcaggaagtcacccattctgtgcgcattggttttggttcctttgtggacaaaacg
gtgctgccctttgtgagcacagtaccctccaaactgcgccacccctgccccacccggctg
gagcgctgccagtcaccattcagctttcaccatgtgctgtccctgacgggggacgcacaa
gccttcgagcgggaggtggggcgccagagtgtgtccggcaatctggactcgcctgaaggt
ggcttcgatgccattctgcaggctgcactctgccaggagcagattggctggagaaatgtg
tcccggctgctggtgttcacttcagacgacacattccatacagctggggacgggaagttg
ggcggcattttcatgcccagtgatgggcactgccacttggacagcaatggcctctacagt
cgcagcacagagtttgactacccttctgtgggtcaggtagcccaggccctctctgcagca
aatatccagcccatctttgctgtcaccagtgccgcactgcctgtctaccaggagctgagt
aaactgattcctaagtctgcagttggggagctgagtgaggactccagcaacgtggtacag
ctcatcatggatgcttataatagcctgtcttccaccgtgacccttgaacactcttcactc
cctcctggggtccacatttcttacgaatcccagtgtgagggtcctgagaagagggagggt
aaggctgaggatcgaggacagtgcaaccacgtccgaatcaaccagacggtgactttctgg
gtttctctccaagccacccactgcctcccagagccccatctcctgaggctccgggccctt
ggcttctcagaggagctgattgtggagttgcacacgctgtgtgactgtaattgcagtgac
acccagccccaggctccccactgcagtgatggccagggacacctacaatgtggtgtatgc
agctgtgcccctggccgcctaggtcggctctgtgagtgctctgtggcagagctgtcctcc
ccagacctggaatctgggtgccgggctcccaatggcacagggcccctgtgcagtggaaag
ggtcactgtcaatgtggacgctgcagctgcagtggacagagctctgggcatctgtgcgag
tgtgacgatgccagctgtgagcgacatgagggcatcctctgcggaggctttggtcgctgc
caatgtggagtatgtcactgtcatgccaaccgcacgggcagagcatgcgaatgcagtggg
gacatggacagttgcatcagtcccgagggagggctctgcagtgggcatggacgctgcaaa
tgcaaccgctgccagtgcttggacggctactatggtgctctatgcgaccaatgcccaggc
tgcaagacaccatgcgagagacaccgggactgtgcagagtgtggggccttcaggactggc
ccactggccaccaactgcagtacagcttgtgcccataccaatgtgaccctggccttggcc
cctatcttggatgatggctggtgcaaagagcggaccctggacaaccagctgttcttcttc
ttggtggaggatgacgccagaggcacggtcgtgctcagagtgagaccccaagaaaaggga
gcagaccacacgcaggccattgtgctgggctgcgtagggggcatcgtggcagtggggctg
gggctggtcctggcttaccggctctcggtggaaatctatgaccgccgggaatacagtcgc
tttgagaaggagcagcaacaactcaactggaagcaggacagtaatcctctctacaaaagt
gccatcacgaccaccatcaatcctcgctttcaagaggcagacagtcccactctctga
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integrated database retrieval system