KEGG PATHWAY: ko00460

PATHWAY: ko00460

Entry

ko00460                     Pathway

Name

Cyanoamino acid metabolism

Class

Metabolism; Metabolism of other amino acids

Pathway map

ko00460

Cyanoamino acid metabolism

Module

M00369

Cyanogenic glycoside biosynthesis, tyrosine => dhurrin [PATH:ko00460]

Other DBs

GO:	0033052 0019756

Orthology

K00495

CYP71AN24; phenylacetaldehyde oxime monooxygenase [EC:1.14.14.44]

K00600

glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]

K00681

ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]

K01188

E3.2.1.21; beta-glucosidase [EC:3.2.1.21]

K01424

E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]

K01455

E3.5.1.49; formamidase [EC:3.5.1.49]

K01501

E3.5.5.1; nitrilase [EC:3.5.5.1]

K01914

asnA; aspartate--ammonia ligase [EC:6.3.1.1]

K05349

bglX; beta-glucosidase [EC:3.2.1.21]

K05350

bglB; beta-glucosidase [EC:3.2.1.21]

K08248

MDL3; (R)-mandelonitrile lyase [EC:4.1.2.10]

K08249

E4.1.2.11; hydroxymandelonitrile lyase [EC:4.1.2.11]

K10566

oxdB; phenylacetaldoxime dehydratase [EC:4.8.1.4]

K10675

E4.2.1.66; cyanide hydratase [EC:4.2.1.66]

K10814

hcnA; hydrogen cyanide synthase HcnA [EC:1.4.99.5]

K10815

hcnB; hydrogen cyanide synthase HcnB [EC:1.4.99.5]

K10816

hcnC; hydrogen cyanide synthase HcnC [EC:1.4.99.5]

K12153

CYP79A2; phenylalanine N-monooxygenase [EC:1.14.14.40]

K13027

CYP79A1; tyrosine N-monooxygenase [EC:1.14.14.36]

K13029

CYP71E1; 4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]

K13030

UGT85B1; cyanohydrin beta-glucosyltransferase [EC:2.4.1.85]

K13031

AH; amygdalin beta-glucosidase [EC:3.2.1.117]

K13032

PH; prunasin beta-glucosidase [EC:3.2.1.118]

K13033

HNL; (S)-hydroxynitrile lyase [EC:4.1.2.47]

K13034

ATCYSC1; L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]

K13035

NIT4; beta-cyano-L-alanine hydratase/nitrilase [EC:3.5.5.4 4.2.1.65]

K13051

ASRGL1, iaaA; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]

K13401

CYP79D1_2; valine N-monooxygenase [EC:1.14.14.38]

K14577

E4.1.2.46; aliphatic (R)-hydroxynitrile lyase [EC:4.1.2.46]

K14984

CYP79D3_4; isoleucine N-monooxygenase [EC:1.14.14.39]

K16265

CYP71E7; (E)-2-methylbutanal oxime monooxygenase [EC:1.14.14.41]

K16266

UGT85K; cyanohydrin UDP-glucosyltransferase [EC:2.4.1.-]

K18282

cynD; cyanide dihydratase [EC:3.5.5.-]

K18592

GGT1_5, CD224; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]

K20802

HNL; (R)-mandelonitrile lyase [EC:4.1.2.10]

K22706

UGT85A19; (R)-mandelonitrile beta-glucosyltransferase [EC:2.4.1.354]

Compound

C00014

Ammonia

C00037

Glycine

C00049

L-Aspartate

C00065

L-Serine

C00079

L-Phenylalanine

C00082

L-Tyrosine

C00097

L-Cysteine

C00152

L-Asparagine

C00183

L-Valine

C00302

Glutamate

C00407

L-Isoleucine

C00488

Formamide

C00561

Mandelonitrile

C00844

Prunasin

C01326

Hydrogen cyanide

C01401

Alanine

C01594

Linamarin

C02512

3-Cyano-L-alanine

C02659

Acetone cyanohydrin

C03004

N-Hydroxy-L-tyrosine

C03219

(E)-2-Methylpropanal oxime

C03742

(S)-4-Hydroxymandelonitrile

C04350

(E)-4-Hydroxyphenylacetaldehyde oxime

C05143

Dhurrin

C05670

3-Aminopropiononitrile

C05711

gamma-Glutamyl-beta-cyanoalanine

C05714

alpha-Aminopropiononitrile

C05715

gamma-Amino-gamma-cyanobutanoate

C06114

gamma-Glutamyl-beta-aminopropiononitrile

C08325

Amygdalin

C08334

Lotaustralin

C15503

N,N-Dihydroxy-L-tyrosine

C16074

Phenylacetonitrile

C16075

(Z)-Phenylacetaldehyde oxime

C18796

(2R)-2-Hydroxy-2-methylbutanenitrile

C19491

(E)-2-Methylbutanal oxime

C19712

N-Hydroxy-L-phenylalanine

C19714

(E)-Phenylacetaldoxime

C19715

N,N-Dihydroxy-L-phenylalanine

C20310

N-Hydroxy-L-isoleucine

C20311

N,N-Dihydroxy-L-isoleucine

C20312

(Z)-2-Methylbutanal oxime

C20313

N-Hydroxy-L-valine

C20314

N,N-Dihydroxy-L-valine

C20315

(Z)-2-Methylpropanal oxime

Reference

PMID:11575729

Authors

Maruyama A, Saito K, Ishizawa K

Title

Beta-cyanoalanine synthase and cysteine synthase from potato: molecular cloning, biochemical characterization, and spatial and hormonal regulation.

Journal

Plant Mol Biol 46:749-60 (2001)
DOI:10.1023/A:1011629703784

Reference

PMID:10636899

Authors

Andersen MD, Busk PK, Svendsen I, Moller BL

Title

Cytochromes P-450 from cassava (Manihot esculenta Crantz) catalyzing the first steps in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin. Cloning, functional expression in Pichia pastoris, and substrate specificity of the isolated recombinant enzymes.

Journal

J Biol Chem 275:1966-75 (2000)
DOI:10.1074/jbc.275.3.1966

Reference

Authors

Hickel A, Hasslacher M, Griengl H.

Title

Hydroxynitrile lyases: Functions and properties

Journal

Physiol Plant 98:891-898 (1996)
DOI:10.1111/j.1399-3054.1996.tb06700.x

Related
pathway

ko00250

Alanine, aspartate and glutamate metabolism