KEGG   PATHWAY: ko04664
Entry
ko04664                     Pathway                                
Name
Fc epsilon RI signaling pathway
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
Pathway map
ko04664  Fc epsilon RI signaling pathway
ko04664

Other DBs
GO: 0045576
Orthology
K00461  ALOX5; arachidonate 5-lipoxygenase [EC:1.13.11.34]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02677  PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
K02833  HRAS; GTPase HRas
K03084  SHIP1, INPP5D; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K03099  SOS; son of sevenless
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K04364  GRB2; growth factor receptor-bound protein 2
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04736  IL3; interleukin 3
K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K05428  IL5; interleukin 5
K05430  IL4; interleukin 4
K05435  IL13; interleukin 13
K05703  FYN; tyrosine-protein kinase Fyn [EC:2.7.10.2]
K05730  VAV; guanine nucleotide exchange factor VAV
K05854  LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K05855  SYK; spleen tyrosine kinase [EC:2.7.10.2]
K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K06276  PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K06856  IGH; immunoglobulin heavy chain
K07361  LCP2; lymphocyte cytosolic protein 2
K07362  LAT; linker for activation of T cells family member 1
K07370  BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
K07983  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma
K08089  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha
K08090  MS4A2, FCER1B; high affinity immunoglobulin epsilon receptor subunit beta
K08091  GAB2; GRB2-associated-binding protein 2
K16342  PLA2G4, CPLA2; cytosolic phospholipase A2 [EC:3.1.1.4]
K20735  ALOX5AP, FLAP; arachidonate 5-lipoxygenase-activating protein
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00374  Heparin
C00388  Histamine
C00696  Prostaglandin D2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02166  Leukotriene C4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12360215
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
DOI:10.1038/nri914
Reference
PMID:14630197
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
DOI:10.1016/j.coi.2003.09.010
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
PMID:10586892
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
DOI:10.1038/35037021
Reference
PMID:16470226
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
DOI:10.1038/nri1782
Reference
PMID:11079101
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
DOI:10.1016/S0065-2776(01)76022-1
Reference
PMID:11449275
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
DOI:10.1038/35084076
Reference
PMID:12145654
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
DOI:10.1038/ni0802-707
Related
pathway
ko00590  Arachidonic acid metabolism
ko04010  MAPK signaling pathway
ko04070  Phosphatidylinositol signaling system

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