Entry Name Pancreatic secretion
Description The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Orthology K01538 FXYD2, ATP1G1; sodium/potassium-transporting ATPase subunit gamma (FXYD domain-containing ion transport regulator 2)
K01539 ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13 ]
K01540 ATP1B, CD298; sodium/potassium-transporting ATPase subunit beta
K04131 CHRM3; muscarinic acetylcholine receptor M3
K04194 CCKAR; cholecystokinin A receptor
K04353 RAP1A; Ras-related protein Rap-1A
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04513 RHOA; Ras homolog gene family, member A
K04588 SCTR; secretin receptor
K04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha
K04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04926 KCNQ1, KV7.1; potassium voltage-gated channel KQT-like subfamily member 1
K04936 KCNMA1, KCA1.1; potassium large conductance calcium-activated channel subfamily M alpha member 1
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K04962 RYR2; ryanodine receptor 2
K04964 TRPC1; transient receptor potential cation channel subfamily C member 1
K05027 CLCA1; calcium-activated chloride channel regulator 1
K05028 CLCA2; calcium-activated chloride channel regulator 2
K05030 CLCA3_4; calcium-activated chloride channel regulator 3/4
K05031 CFTR, ABCC7; cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6 ]
K05742 SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
K07836 RAP1B; Ras-related protein Rap-1B
K07884 RAB3D; Ras-related protein Rab-3D
K07886 RAB27B; Ras-related protein Rab-27B
K07901 RAB8A, MEL; Ras-related protein Rab-8A
K07904 RAB11A; Ras-related protein Rab-11A
K09632 CTRL; chymotrypsin-like protease [EC:3.4.21.-]
K10951 SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2
K13575 SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4
K13855 SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
K14074 PNLIPRP1, PLRP1; pancreatic lipase-related protein 1 [EC:3.1.1.3 ]
K14075 PNLIPRP2, PLRP2; pancreatic lipase-related protein 2 [EC:3.1.1.3 ]
K14077 TPCN2; two pore calcium channel protein 2
K14078 SLC26A3, DRA; solute carrier family 26 (chloride anion exchanger), member 3
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C13051 Nicotinic acid adenine dinucleotide phosphate
Reference Authors Petersen OH, Tepikin AV
Title Polarized calcium signaling in exocrine gland cells.
Journal Reference Authors Williams JA
Title Regulation of acinar cell function in the pancreas.
Journal Reference Authors Williams JA
Title Regulation of pancreatic acinar cell function.
Journal Reference Authors Bi Y, Williams JA
Title Receptor biology and signal transduction in pancreatic acinar cells.
Journal Reference Authors Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
Title Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Journal Reference Authors Kanno T
Title Ca2+ signaling in the pancreatic acinus.
Journal Pancreas 16:273-6 (1998)
Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
Title Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
Journal Reference Authors Chu JY, Yung WH, Chow BK
Title Secretin: a pleiotrophic hormone.
Journal Reference Authors Siu FK, Lam IP, Chu JY, Chow BK
Title Signaling mechanisms of secretin receptor.
Journal Reference Authors Steward MC, Ishiguro H, Case RM
Title Mechanisms of bicarbonate secretion in the pancreatic duct.
Journal Reference Authors Kim D, Steward MC
Title The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
Journal Reference Authors Whitcomb DC, Lowe ME
Title Human pancreatic digestive enzymes.
Journal Reference Authors Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
Title Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Journal Reference Authors Cancela JM, Churchill GC, Galione A
Title Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Journal Reference Authors Parekh AB
Title Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
Journal Reference Authors Williams JA, Chen X, Sabbatini ME
Title Small G proteins as key regulators of pancreatic digestive enzyme secretion.
Journal Related ko04973 Carbohydrate digestion and absorption
ko04974 Protein digestion and absorption
ko04975 Fat digestion and absorption
ko04977 Vitamin digestion and absorption
