KEGG ORTHOLOGY: K07836

ORTHOLOGY: K07836

Entry

K07836                      KO

Symbol

RAP1B

Name

Ras-related protein Rap-1B

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04510

Focal adhesion

map04520

Adherens junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04720

Long-term potentiation

map04722

Neurotrophin signaling pathway

map04934

Cushing syndrome

map04972

Pancreatic secretion

map05211

Renal cell carcinoma

map05417

Lipid and atherosclerosis

Disease

H00978

Thrombocytopenia (THC)

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04014 Ras signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04015 Rap1 signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04024 cAMP signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07836  RAP1B; Ras-related protein Rap-1B
   04520 Adherens junction
    K07836  RAP1B; Ras-related protein Rap-1B
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07836  RAP1B; Ras-related protein Rap-1B
   04670 Leukocyte transendothelial migration
    K07836  RAP1B; Ras-related protein Rap-1B
   04062 Chemokine signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
  09154 Digestive system
   04972 Pancreatic secretion
    K07836  RAP1B; Ras-related protein Rap-1B
  09156 Nervous system
   04720 Long-term potentiation
    K07836  RAP1B; Ras-related protein Rap-1B
   04722 Neurotrophin signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K07836  RAP1B; Ras-related protein Rap-1B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07836  RAP1B; Ras-related protein Rap-1B
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K07836  RAP1B; Ras-related protein Rap-1B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07836  RAP1B; Ras-related protein Rap-1B
   04031 GTP-binding proteins
    K07836  RAP1B; Ras-related protein Rap-1B
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of other body fluids (saliva and urine)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of colorectal cancer cells
   K07836  RAP1B; Ras-related protein Rap-1B
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K07836  RAP1B; Ras-related protein Rap-1B

Genes

HSA:	5908(RAP1B)

PTR:	452065(RAP1B)

PPS:	100995578(RAP1B)

GGO:	101125880(RAP1B)

PON:	100171907(RAP1B)

PPYG:

129009944(RAP1B)

NLE:	100593411(RAP1B)

HMH:	116478979(RAP1B)

SSYN:

129461142(RAP1B) 129490367

MCC:	693750 718171(RAP1B)

MCF:	102133022(RAP1B)

MTHB:

126930986 126937705

MNI:	105473408(RAP1B)

CSAB:

103215555 103238680(RAP1B)

CATY:

105600503(RAP1B)

PANU:

101013495(RAP1B)

TGE:	112635460(RAP1B)

MLEU:

105537110(RAP1B)

RRO:	104658672(RAP1B)

RBB:	108532250(RAP1B)

TFN:	117089777(RAP1B) 117098609

PTEH:

111528626(RAP1B) 111532119

CANG:

105502654(RAP1B)

CJC:	100411763 100413220(RAP1B)

SBQ:	101036065(RAP1B)

CIMI:

108300232(RAP1B)

ANAN:

105711998(RAP1B)

CSYR:

103250369 103253054 103253055 103268438

MMUR:

105880992(RAP1B)

LCAT:

123639540(RAP1B)

PCOQ:

105808407(RAP1B)

OGA:	100941765 100959791(RAP1B)

MMU:	215449(Rap1b)

MCAL:

110303320(Rap1b)

MPAH:

110326460(Rap1b)

RNO:	171337(Rap1b)

MCOC:

116075736(Rap1b)

ANU:	117696422(Rap1b)

ASYL:

127671189(Rap1b)

MUN:	110562151(Rap1b)

CGE:	100769542(Rap1b)

MAUA:

101823756(Rap1b)

PROB:

127215719(Rap1b)

PLEU:

114693311(Rap1b)

MORG:

121461538(Rap1b)

MFOT:

126515662

AAMP:

119803252(Rap1b)

NGI:	103745076(Rap1b)

HGL:	101714409 101726671(Rap1b)

CPOC:

100713271 100734094(Rap1b)

CCAN:

109699305

DORD:

105989638(Rap1b)

DSP:	122124042(Rap1b)

PLOP:

125345750 125361483(Rap1b)

NCAR:

124982482

MMMA:

107140075(Rap1b) 107140230

ITI:	101962074 101969595(Rap1b)

OCU:

100339891

OPI:	101518056(RAP1B)

TUP:	102472381(RAP1B)

GVR:	103595400(RAP1B)

CFA:	608981(RAP1B)

CLUD:

112677882(RAP1B)

VVP:	112922290(RAP1B)

VLG:	121476667 121491095(RAP1B)

NPO:	129511430(RAP1B)

AML:	100480240(RAP1B)

UMR:	103656863(RAP1B) 103659828

UAH:	113256300(RAP1B) 123000663

UAR:	123787151(RAP1B)

ELK:

111141969

LLV:	125106325 125107556

MPUF:

101691404(RAP1B)

MNP:	132019439(RAP1B)

MLK:	131839131(RAP1B)

NVS:	122892522(RAP1B)

ORO:	101383971(RAP1B)

EJU:	114214898(RAP1B)

ZCA:	113921540(RAP1B)

MLX:	118008596(RAP1B)

NSU:	110570611(RAP1B)

LWW:	102732389(RAP1B)

FCA:	101095993(RAP1B)

PYU:	121040776(RAP1B)

PCOO:

112863816(RAP1B)

PBG:	122474003(RAP1B)

PVIV:

125169828(RAP1B)

LRUF:

124502483

LGF:	123591646(RAP1B)

AJU:

106966345

PTG:	102965011(RAP1B)

PPAD:

109259557 109270479(RAP1B)

PUC:

125919321

PLEZ:

122224810(RAP1B)

HHV:	120240794(RAP1B)

BTA:	327708(RAP1B) 789148

BOM:	102265384(RAP1B) 102277019 138991483

BIU:	109559248(RAP1B)

BBUB:

102400135(RAP1B)

BBIS:

104989774(RAP1B)

CHX:	102174543(RAP1B)

OAS:	101106317(RAP1B) 114113232

BTAX:

128047462(RAP1B)

CSUM:

138079037(RAP1B)

ODA:	120857713(RAP1B)

CCAD:

122427076(RAP1B)

MREE:

136167232(RAP1B)

OVR:	110139114(RAP1B)

MBEZ:

129537257(RAP1B)

SSC:	100152555(RAP1B)

CFR:	102524037(RAP1B)

CBAI:

105081341(RAP1B)

CDK:	105101089(RAP1B)

VPC:	102535500(RAP1B)

BACU:

103018737 103019004(RAP1B)

BMUS:

118898513 118900105 118901719(RAP1B)

LVE:	103083426(RAP1B) 103088976

OOR:	101284281(RAP1B)

LALB:

132529145(RAP1B)

DLE:	111173766(RAP1B)

PCAD:

102980344(RAP1B) 102989853

PSIU:

116753261 116757757 116760187(RAP1B)

NASI:

112393952(RAP1B) 112407608

ECB:	100052025(RAP1B)

EPZ:	103558687(RAP1B)

EAI:	106843586(RAP1B)

MYB:	102254910(RAP1B)

MYD:	102772411(RAP1B)

MMYO:

118651809(RAP1B)

MLF:	102441232(RAP1B)

MDT:	132225178 132227892(RAP1B)

MYUM:

139005586 139006931(RAP1B)

PKL:	118724188 118729245(RAP1B)

EFUS:

103292519(RAP1B)

MNA:	107526932(RAP1B)

DRO:	112318977(RAP1B)

SHON:

118989371(RAP1B)

AJM:	119036470 119042914(RAP1B)

PDIC:

114512692(RAP1B)

PHAS:

123812719(RAP1B)

MMF:	118624733(RAP1B)

PPAM:

129075864(RAP1B)

HAI:	109381707(RAP1B)

RFQ:	117028675(RAP1B)

PALE:

102883778(RAP1B)

PGIG:

120605040(RAP1B)

PVP:	105302160(RAP1B)

RAY:	107512678(RAP1B)

MJV:	108392641 108407356(RAP1B)

TOD:	119247531(RAP1B)

SARA:

101545287(RAP1B)

SFUM:

130035337 130038956(RAP1B) 130040052 130040161

SETR:

126006387 126021897(RAP1B)

LAV:	100665185(RAP1B)

TMU:

101348129

ETF:	101641765 101659498(RAP1B) 101664314

DNM:	101421103(RAP1B) 101431477

MDO:	100014092(RAP1B)

GAS:	123233503 123234910 123248572(RAP1B)

SHR:	100920135(RAP1B)

AFZ:	127538164 127541432

PCW:	110211041(RAP1B)

TVP:	118847569 118850626(RAP1B)

PBRV:

138155820(RAP1B)

OAA:	100079331(RAP1B)

TACU:

119936996(RAP1B)

GGA:	417840(RAP1B)

PCOC:

116226600(RAP1B)

MGP:	100543810(RAP1B)

CJO:	107310547(RAP1B)

TPAI:

128073883(RAP1B)

LMUT:

125688069(RAP1B)

NMEL:

110392786(RAP1B)

APLA:

101789925(RAP1B)

ACYG:

106046993(RAP1B)

CATA:

118246831(RAP1B)

AFUL:

116487830(RAP1B)

TGU:	100223739(RAP1B)

LSR:	110477997(RAP1B)

SCAN:

103813454(RAP1B)

PMOA:

120499794(RAP1B)

OTC:	121339432(RAP1B)

PRUF:

121352517(RAP1B)

ATRC:

139588297(RAP1B)

GFR:	102042554(RAP1B)

FAB:	101812484(RAP1B)

OMA:	130264553(RAP1B)

PHI:	102099438(RAP1B)

PMAJ:

107204636(RAP1B)

CCAE:

111932715(RAP1B)

CCW:	104698372(RAP1B)

CBRC:

103614815(RAP1B)

ACOE:

138100915(RAP1B)

ETL:	114062143(RAP1B)

ZAB:	102063354(RAP1B)

ZLE:	135442277(RAP1B)

ACHL:

103797087(RAP1B)

SVG:	106855333(RAP1B)

MMEA:

130580110(RAP1B)

HRT:	120751456(RAP1B)

SATI:

136361331(RAP1B)

CCIC:

134043551(RAP1B)

FPG:	101924298(RAP1B)

FCH:	102047995(RAP1B)

CCRI:

104166782(RAP1B)

NNT:

104411965

SHAB:

115605366(RAP1B)

ACUN:

113487398(RAP1B)

TALA:

104364250(RAP1B)

ACHC:

115336097(RAP1B)

HALD:

104323997(RAP1B)

HLE:	104828219(RAP1B)

AGEN:

126034345

HHAR:

128135375(RAP1B)

GCL:

127015780

CSTI:

104563621(RAP1B)

LDI:	104341426(RAP1B)

MNB:	103774779(RAP1B)

DPUB:

104305542(RAP1B)

PPUS:

135187667(RAP1B)

AVIT:

104270664(RAP1B)

BRHI:

104495704(RAP1B)

EGZ:	104132908(RAP1B)

NNI:	104011007(RAP1B)

PCRI:

104030981(RAP1B)

PCAO:

104051011(RAP1B)

PADL:

103919959(RAP1B)

AFOR:

103893929(RAP1B)

FGA:	104084036(RAP1B)

GSTE:

104254385(RAP1B)

CLV:	102083646(RAP1B)

MUI:	104537576(RAP1B)

PGUU:

104465991(RAP1B)

PLET:

104615422(RAP1B)

EHS:	104504649(RAP1B)

CMAC:

104474756(RAP1B)

CUCA:

104061349(RAP1B)

TEO:	104373969(RAP1B)

BREG:

104630904(RAP1B)

OHA:	104326768(RAP1B)

ACAR:

104527054(RAP1B)

CPEA:

104388816(RAP1B)

CVF:	104288923(RAP1B)

RTD:	128911066(RAP1B)

CRID:

134510108(RAP1B)

AAM:	106488632(RAP1B)

AROW:

112970437(RAP1B)

NPD:	112958867(RAP1B)

TGT:	104574441(RAP1B)

DNE:	112983294(RAP1B)

SCAM:

104142047(RAP1B)

ASN:	102382819(RAP1B)

AMJ:	102561548(RAP1B)

CPOO:

109315520(RAP1B)

GGN:	109295712(RAP1B)

PSS:	102444055(RAP1B)

CMY:	102947916(RAP1B)

CCAY:

125630229(RAP1B)

DCC:	119859043(RAP1B)

CPIC:

101935007(RAP1B)

TST:	117877671(RAP1B)

CABI:

116834442(RAP1B)

MRV:	120383281(RAP1B)

ACS:	100553457(rap1b)

ASAO:

132776179(RAP1B)

PVT:	110075099(RAP1B)

SUND:

121930868(RAP1B)

PBI:	103064511(RAP1B)

PMUR:

107284411(RAP1B)

CTIG:

120307687(RAP1B)

TSR:	106545246(RAP1B)

PGUT:

117655710(RAP1B)

APRI:

131201824(RAP1B)

PTEX:

113435814(RAP1B)

NSS:	113412267(RAP1B)

VKO:	123033326(RAP1B)

PMUA:

114605252(RAP1B)

PRAF:

128422090(RAP1B)

ZVI:	118090625(RAP1B)

HCG:	128327323(RAP1B)

GJA:	107105721(RAP1B)

STOW:

125434778(RAP1B)

EMC:	129335857(RAP1B)

XLA:	108713157 379883(rap1b.L)

XTR:	493557(rap1b)

NPR:	108804561(RAP1B)

RTEM:

120931994(RAP1B)

BBUF:

120980486(RAP1B)

BGAR:

122928017(RAP1B)

PWL:	138288042(RAP1B)

MUO:	115478180(RAP1B)

GSH:	117363953(RAP1B)

DRE:	321107(rap1b)

SRX:	107725524 107732995(rap1b)

SANH:

107664881 107695907

SGH:	107553881(rap1b)

CCAR:

109067672 109072174(rap1b)

CAUA:

113048121 113063276

CGIB:

127956746 127974411

PTET:

122343501(rap1b)

LROH:

127163881(rap1b)

OMC:	131539666(rap1b)

PPRM:

120476984(rap1b)

RKG:	130072225(rap1b)

MAMB:

125246225(rap1b)

CIDE:

127511385

CERY:

137024478(rap1b)

MASI:

127434844 127436684

TROS:

130547968(rap1b)

TDW:	130420368(rap1b)

MANU:

129432000(rap1b)

PDAB:

135749767(rap1b) 135774828

IPU:	100528315(rap1b)

IFU:	128623063(rap1b)

PHYP:

113532015(rap1b)

SMEO:

124400808(rap1b)

TFD:	113645502(rap1b)

TVC:	132859455(rap1b)

CGAR:

128534206(rap1b)

NGRA:

132869809(rap1b)

TRN:	134315052(rap1b)

AMEX:

103035254(rap1b)

CMAO:

118812483(rap1b)

EEE:	113572528(rap1b)

CHAR:

105892499

SPIL:

134070935(rap1b)

TRU:

101070080

TFS:

130519413

TNG:	GSTEN00012332G001

LCO:	104935802(rap1b)

TBEN:

PGEO:

EMAC:

ELY:

EFO:

SLUC:

PFLV:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:	100707998(rap1b)

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:	116736693(rap1b)

PRET:

103459326(rap1b)

PFOR:

103133068 103154285(rap1b)

PLAI:

106940239 106941801

PMEI:

106917317(rap1b)

GAF:

122826820

PPRL:

129352835

CVG:	107089072(rap1b)

CTUL:

119796580

GMU:

124882697

NFU:	107387503(rap1b)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111225046(rap1b)

SLAL:

111661323

XGL:

120803527

HCQ:	109532657(rap1b)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110161898(rap1b)

ENY:

MALB:

BSPL:

SJO:

SSCO:

SASA:

106576640 106593497(RAP1B)

STRU:

115182047 115182953

OTW:	121842780 121845253

OMY:	110490689 118936571

OGO:	124020931 124020932 124022472

OKI:

116360631

OKE:	127927760 127927765

OMM:	135515552 135531817

OCLA:

139379621 139392865 139392866

SNH:

120050139

CCLU:

121553840

ELS:	105017798(rap1b)

OEP:

134037420

SFM:	108920959 108936546(rap1b)

PKI:	111844324 111851234(rap1b)

AANG:

118218837 118231987

AROT:

135246134 135258784

CCOG:

133118877 133134726

LOC:	102697231(rap1b)

PSPA:

121317980 121320084

ARUT:

117415871 117419830

PSEX:

120539577(rap1b)

LCM:	102354357(RAP1B)

CMK:

RTP:

CPLA:

HOC:

LERI:

BBEL:

CIN:

SCLV:

SKO:

LDC:

HAME:

ESN:

MRJ:

PORN:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

GAE:

HRF:

HASI:

SMM:	Smp_071250

OVI:	T265_00309 T265_07457

EGL:	EGR_01616 EGR_03026

ATEN:

116301360

MCAZ:

138023757

MFOO:

137972991

TAD:	TRIADDRAFT_55369

AQU:

105313915

SCE:	YGR152C(RSR1)

SEUB:

DI49_2116

SPAO:

SPAR_G03670

AGO:	AGOS_AFR464W

ERC:

Ecym_1407

KLA:	KLLA0_C12001g

KMX:	KLMA_60196(RSR1)

LTH:	KLTH0H09042g

VPO:	Kpol_1026p12

ZRO:	ZYRO0G07018g

CGR:	2887368(GVI51_E02871)

NCS:	NCAS_0A01890(NCAS0A01890)

NDI:	NDAI_0D03820(NDAI0D03820)

TPF:	TPHA_0K01820(TPHA0K01820)

TBL:	TBLA_0B00370(TBLA0B00370)

TGB:	HG536_0D04840

TDL:	TDEL_0F02770(TDEL0F02770)

KAF:	KAFR_0F03670(KAFR0F03670)

KNG:	KNAG_0D03780(KNAG0D03780)

ZMK:	HG535_0B05640

SLUD:

SCDLUD_001545

DHA:	DEHA2C16544g

PIC:	PICST_57530

PGU:	PGUG_03860

SPAA:

SPAPADRAFT_49461

LBG:	92206220(LODBEIA_P10240)

CAL:	CAALFM_CR02140WA(RSR1)

CTP:	CTRG_00897

COT:	CORT_0A00810

CDU:	CD36_27060(RSR1)

CTEN:

18250026(RSR1)

CLU:	CLUG_03767

CLUS:

A9F13_01g03751

CAUR:

CJI96_0002950

ASAU:

88174773(PUMCH_003710)

PPA:	PAS_chr2-2_0347

PKZ:	C5L36_0A11320

BNN:	FOA43_004055(RSR1)

BBRX:

BRETT_002898(RSR1)

OPA:	HPODL_05361

YLI:	2908782(YALI2_E01056g)

SLB:	AWJ20_3825(RSR1)

SMP:	10801369(SMAC4_09077)

MGR:

MGG_02727

TMN:	UCRPA7_2837

FGR:	FGSG_08817

FPU:	FPSE_11987

FPOA:

FPOAC1_004955(RSR1)

FVN:	FVRRES_05473

FVR:	FVEG_02390

FOX:	FOXG_03523

NHE:	NECHADRAFT_92074

FFC:	NCS54_00423400

FKR:	NCS57_00428700

TRE:	TRIREDRAFT_76880(rsr1)

TRR:	M419DRAFT_97568

TATV:

25781841(TrAtP1_001989)

MAW:	19245284(RSR1_1)

MAJ:

MAA_10959

MBRN:

26245536(RSR1)

PCHM:

VFPPC_13713

CMT:

CCM_00788

AMUS:

LMH87_002062

PLJ:	28882579(PLICBS_001407)

PTKZ:

JDV02_010060(RSR1)

CFJ:	CFIO01_12692

SAPO:

SAPIO_CDS5131

PFY:	PFICI_03039

SSL:	SS1G_03294

BFU:	BCIN_08g02920(Bcrsr1)

MBE:

MBM_09336

PSCO:

LY89DRAFT_278291

GLZ:	GLAREA_09150

ACT:	ACLA_011600

NFI:	NFIA_078360

AOR:	AO090020000491

ANG:	An07g04240

TRG:	TRUGW13939_10630

CIM:	CIMG_06722

CPW:	9695469(RSR1)

URE:	UREG_03736

ABE:

ARB_00736

TVE:

TRV_08011

PBN:	PADG_07371

AJE:	HCAG_00675

BGH:	BDBG_01197

PNO:	SNOG_09547

PTE:

PTT_20340

BZE:	COCCADRAFT_39940

BSC:	COCSADRAFT_91616

BOR:	COCMIDRAFT_37929

AALT:

CC77DRAFT_1032527

ZTR:	MYCGRDRAFT_30706 MYCGRDRAFT_69392

PFJ:	MYCFIDRAFT_152766

BCOM:

BAUCODRAFT_141164

TML:	GSTUM_00000073001

CCAC:

CcaHIS019_0303840(CcaverHIS019_0303840)

PPL:	POSPLDRAFT_27587

PCO:	PHACADRAFT_251819

UMA:	UMAG_11909

PFP:	PFL1_00443

PGR:	PGTG_12740

MLR:	MELLADRAFT_35390

DDI:	DDB_G0291237(rapA)

DPP:	DICPUDRAFT_59134(rapA)

DFA:	DFA_03257 DFA_12095(rapA)

ACAN:

ACA1_215900 ACA1_278840

NGR:	NAEGRDRAFT_69615

TVA:	TVAG_2v0675690 TVAG_2v0820100 TVAG_2v0874390

» show all

Reference

PMID:10579920

Authors

Zwartkruis FJ, Bos JL

Title

Ras and Rap1: two highly related small GTPases with distinct function.

Journal

Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695

Reference

PMID:3137530

Authors

Pizon V, Lerosey I, Chardin P, Tavitian A

Title

Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).

Journal

Nucleic Acids Res 16:7719 (1988)
DOI:10.1093/nar/16.15.7719

Sequence

[hsa:5908]

LinkDB

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