Entry Name Malaria
Description Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form.
Class Human Diseases; Infectious disease: parasiticBRITE hierarchy
Pathway map Disease Orthology K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K03161 TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
K04011 CR1, CD35; complement component (3b/4b) receptor 1
K04519 IL1B; interleukin 1 beta
K04550 LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
K04659 THBS2S; thrombospondin 2/3/4/5
K04729 MYD88; myeloid differentiation primary response protein MyD88
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1 ]
K05423 CSF3, GCSF; granulocyte colony-stimulating factor
K05443 IL10, CSIF; interleukin 10
K05460 HGF; hepatocyte growth factor
K05482 IL18, IL1F4; interleukin 18
K05718 ITGAL, CD11a; integrin alpha L
K06257 SDC1, CD138; syndecan 1
K06464 ITGB2, CD18; integrin beta 2
K06471 PECAM1, CD31; platelet/endothelial cell adhesion molecule
K06490 ICAM1, CD54; intercellular adhesion molecule 1
K06494 SELE, CD62E; selectin, endothelial cell
K06496 SELP, CD62P; selectin, platelet
K06508 CD81, TAPA1, TSPAN28; CD81 antigen
K06527 VCAM1, CD106; vascular cell adhesion molecule 1
K06543 KLRB, CD161; killer cell lectin-like receptor subfamily B
K06574 ACKR1, DARC, CD234; atypical chemokine receptor 1
K06575 GYPA, CD235a; glycophorin A
K06576 GYPC, CD236; glycophorin C
K06728 KLRK1, CD314; killer cell lectin-like receptor subfamily K member 1
K10030 IL8, CXCL8; interleukin 8
K10159 TLR2, CD282; toll-like receptor 2
K10160 TLR4, CD284; toll-like receptor 4
K10161 TLR9, CD289; toll-like receptor 9
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K13375 TGFB1; transforming growth factor beta-1
K13376 TGFB2; transforming growth factor beta-2
K13377 TGFB3; transforming growth factor beta-3
K13822 HBA; hemoglobin subunit alpha
K13823 HBB; hemoglobin subunit beta
K13833 SPECT; sporozoite microneme protein
K13834 SPECT2; sporozoite microneme protein 2
K13835 CELTOS; cell-traversal protein for ookinetes and sporozoites
K13836 CSP; circumsporozoite protein
K13837 TRAP; thrombospondin-related anonymous protein
K13838 MSP1; merozoite surface protein 1
K13839 MSP2; merozoite surface protein 2
K13840 MSP3; merozoite surface protein 3
K13841 MSP4; merozoite surface protein 4
K13842 MSP5; merozoite surface protein 5
K13843 MSP6; merozoite surface protein 6
K13844 MSP8; merozoite surface protein 8
K13845 AMA-1; apical merozoite antigen 1
K13846 PVDR, DBP; Duffy binding protein
K13847 EBA175; erythrocyte-binding antigen 175
K13848 EBA140; erythrocyte-binding antigen 140
K13849 RBP; reticulocyte-binding protein
K13850 PFEMP1; erythrocyte membrane protein 1
K13851 RIF; repetitive interspersed family protein
K13852 STEVOR; subtelomeric variable open reading frame
K14624 CCL2, MCP1; C-C motif chemokine 2
K16336 SDC2, CD362; syndecan 2
K16857 THBS1; thrombospondin 1
K20925 GYPB, CD235b; glycophorin B
K23459 KLRA, LY49; killer cell lectin-like receptor subfamily A
Compound Reference Authors Morahan BJ, Wang L, Coppel RL
Title No TRAP, no invasion.
Journal Reference Authors Shakibaei M, Frevert U
Title Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans.
Journal Reference Authors Silvie O, Franetich JF, Renia L, Mazier D
Title Malaria sporozoite: migrating for a living.
Journal Reference Authors Mota MM, Giordano S, Rodriguez A
Title Targeting Plasmodium host cells: survival within hepatocytes.
Journal Reference Authors Cowman AF, Crabb BS
Title The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
Journal Reference Authors O'Donnell RA, Blackman MJ
Title The role of malaria merozoite proteases in red blood cell invasion.
Journal Reference Authors Iyer J, Gruner AC, Renia L, Snounou G, Preiser PR
Title Invasion of host cells by malaria parasites: a tale of two protein families.
Journal Reference Authors Chitnis CE
Title Molecular insights into receptors used by malaria parasites for erythrocyte invasion.
Journal Reference Authors Rasti N, Wahlgren M, Chen Q
Title Molecular aspects of malaria pathogenesis.
Journal Reference Authors Clark IA, Rockett KA, Cowden WB
Title Proposed link between cytokines, nitric oxide and human cerebral malaria.
Journal Reference Authors Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
Title Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Journal Reference Authors Chen Q, Schlichtherle M, Wahlgren M
Title Molecular aspects of severe malaria.
Journal Reference Authors Miller LH, Baruch DI, Marsh K, Doumbo OK
Title The pathogenic basis of malaria.
Journal Reference Authors Faille D, El-Assaad F, Alessi MC, Fusai T, Combes V, Grau GE
Title Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.
Journal Reference Authors Schofield L, Grau GE
Title Immunological processes in malaria pathogenesis.
Journal Reference Authors Ishino T, Yano K, Chinzei Y, Yuda M
Title Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.
Journal Reference Authors Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M
Title CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts.
Journal Reference Authors Cox D, McConkey S
Title The role of platelets in the pathogenesis of cerebral malaria.
Journal Related ko04610 Complement and coagulation cascades
ko04620 Toll-like receptor signaling pathway
