KEGG   PATHWAY: kpb00270
Entry
kpb00270                    Pathway                                
Name
Cysteine and methionine metabolism - Klebsiella pneumoniae blaNDM-1
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
kpb00270  Cysteine and methionine metabolism
kpb00270

Module
kpb_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:kpb00270]
kpb_M00021  Cysteine biosynthesis, serine => cysteine [PATH:kpb00270]
kpb_M00034  Methionine salvage pathway [PATH:kpb00270]
kpb_M00035  Methionine degradation [PATH:kpb00270]
kpb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpb00270]
Other DBs
GO: 0006534 0006555
Organism
Klebsiella pneumoniae blaNDM-1 [GN:kpb]
Gene
FH42_16110  cysE; serine acetyltransferase [KO:K00640] [EC:2.3.1.30]
FH42_22980  cysteine synthase [KO:K01738] [EC:2.5.1.47]
FH42_09920  cysteine synthase [KO:K01738] [EC:2.5.1.47]
FH42_13315  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
FH42_13405  cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
FH42_03460  bifunctional beta-cystathionase/maltose regulon regulatory protein [KO:K14155] [EC:4.4.1.13]
FH42_13310  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
FH42_22460  homocysteine methyltransferase [KO:K00547] [EC:2.1.1.10]
FH42_18360  metH; B12-dependent methionine synthase [KO:K00548] [EC:2.1.1.13]
FH42_17990  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
FH42_06870  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
FH42_12860  S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]
FH42_21450  S-adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]
FH42_21455  spermidine synthase [KO:K00797] [EC:2.5.1.16]
FH42_21715  5'-methylthioadenosine nucleosidase [KO:K01243] [EC:3.2.2.9]
FH42_24165  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
FH42_06670  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FH42_10690  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FH42_24170  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
FH42_24210  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
FH42_24260  haloacid dehalogenase [KO:K09880] [EC:3.1.3.77]
FH42_24255  acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
FH42_18535  aromatic amino acid aminotransferase [KO:K00832] [EC:2.6.1.57]
FH42_03095  aromatic amino acid aminotransferase [KO:K00832] [EC:2.6.1.57]
FH42_03075  aspartate aminotransferase [KO:K08969] [EC:2.6.1.117]
FH42_07825  Free methionine-R-sulfoxide reductase [KO:K08968] [EC:1.8.4.14]
FH42_26755  modification methylase EcoRII [KO:K00558] [EC:2.1.1.37]
FH42_08230  DNA cytosine methylase [KO:K00558] [EC:2.1.1.37]
FH42_08425  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
FH42_11105  S-ribosylhomocysteinase [KO:K07173] [EC:4.4.1.21]
FH42_18390  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FH42_20820  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FH42_17525  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
FH42_04900  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FH42_15330  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FH42_18335  homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
FH42_17520  cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
FH42_17705  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FH42_11110  glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
FH42_12885  glutathione synthetase [KO:K01920] [EC:6.3.2.3]
FH42_00675  aromatic amino acid aminotransferase [KO:K00813] [EC:2.6.1.1]
FH42_10365  sseA; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
FH42_04135  ldh; lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
FH42_12235  racemase [KO:K25316] [EC:5.1.1.10]
FH42_08175  cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]
FH42_14545  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
FH42_07735  serine dehydratase [KO:K01752] [EC:4.3.1.17]
FH42_11720  serine dehydratase [KO:K01752] [EC:4.3.1.17]
FH42_09965  cysM; cysteine synthase [KO:K12339] [EC:2.5.1.144]
FH42_22170  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_24220  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_12710  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_00575  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
kpb00010  Glycolysis / Gluconeogenesis
kpb00250  Alanine, aspartate and glutamate metabolism
kpb00260  Glycine, serine and threonine metabolism
kpb00290  Valine, leucine and isoleucine biosynthesis
kpb00430  Taurine and hypotaurine metabolism
kpb00480  Glutathione metabolism
kpb00620  Pyruvate metabolism
kpb00640  Propanoate metabolism
kpb00770  Pantothenate and CoA biosynthesis
kpb00900  Terpenoid backbone biosynthesis
kpb00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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