KEGG   PATHWAY: leri00564
Entry
leri00564                   Pathway                                
Name
Glycerophospholipid metabolism - Leucoraja erinacea (little skate)
Class
Metabolism; Lipid metabolism
Pathway map
leri00564  Glycerophospholipid metabolism
leri00564

Module
leri_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:leri00564]
leri_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:leri00564]
leri_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:leri00564]
Other DBs
GO: 0006650
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129709677  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
129698606  LOW QUALITY PROTEIN: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
129698802  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
129713181  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
129704071  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
129701278  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
129713145  gpat4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
129711918  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
129699540  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
129703079  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
129697529  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
129697498  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
129708783  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129709851  lysophospholipid acyltransferase 2-like [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129697066  lysophospholipid acyltransferase 2-like [KO:K13517] [EC:2.3.1.51 2.3.1.-]
129696966  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
129708126  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
129696488  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
129711331  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
129700890  plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
129714492  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
129696365  lpin2; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
129697099  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
129707360  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
129713235  phospholipid phosphatase 5-like isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
129704013  plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
129713030  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
129702146  diacylglycerol kinase theta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
129705864  dgkza; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
129698553  diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
129706243  dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
129702799  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
129703558  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
129708493  dgke; LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
129714645  diacylglycerol kinase beta-like [KO:K00901] [EC:2.7.1.107]
129706319  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
129708777  choline/ethanolaminephosphotransferase 1-like isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
129703416  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
129700291  5'-3' exonuclease PLD3-like [KO:K16860] [EC:3.1.4.4]
129714235  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
129715505  5'-3' exonuclease PLD3-like [KO:K16860] [EC:3.1.4.4]
129705133  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
129695135  basic phospholipase A2 acanthin-1-like [KO:K01047] [EC:3.1.1.4]
129709119  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129709120  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129709121  phospholipase A2 superbin b-like [KO:K01047] [EC:3.1.1.4]
129709122  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
129709144  pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
129712932  basic phospholipase A2 myotoxin I-like [KO:K01047] [EC:3.1.1.4]
129712945  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
129709284  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129709285  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129709286  basic phospholipase A2 pseudexin B chain-like [KO:K01047] [EC:3.1.1.4]
129702209  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129705924  basic phospholipase A2 F17-like [KO:K01047] [EC:3.1.1.4]
129709548  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
129710847  protein PROCA1-like [KO:K01047] [EC:3.1.1.4]
129706723  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
129706724  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129715671  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
129700513  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
129701123  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
129713941  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
129694785  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129694787  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129694788  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129705054  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
129711346  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
129696300  acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
129705134  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
129709712  LOW QUALITY PROTEIN: acyl-protein thioesterase 2-like [KO:K06130] [EC:3.1.1.5]
129712135  pnpla7b; patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
129714464  patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
129699297  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
129712908  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
129694238  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
129705708  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
129707850  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
129710375  phosphoethanolamine/phosphocholine phosphatase-like [KO:K06124] [EC:3.1.3.75]
129702658  choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
129703409  choline-phosphate cytidylyltransferase A-like isoform X1 [KO:K00968] [EC:2.7.7.15]
129697160  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
129708873  etnk2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
129705980  ethanolamine kinase 1-like [KO:K00894] [EC:2.7.1.82]
129708199  pcyt2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
129699379  ethanolamine-phosphate phospho-lyase-like [KO:K14286] [EC:4.2.3.2]
129706720  pemt; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
129713262  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
129699992  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
129702549  pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
129696167  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
129705852  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
129709523  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
129708238  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
129699295  crls1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
129699745  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
129704806  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
leri00010  Glycolysis / Gluconeogenesis
leri00260  Glycine, serine and threonine metabolism
leri00561  Glycerolipid metabolism
leri00562  Inositol phosphate metabolism
leri00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
leri00565  Ether lipid metabolism
leri00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

DBGET integrated database retrieval system