KEGG   PATHWAY: leri03420
Entry
leri03420                   Pathway                                
Name
Nucleotide excision repair - Leucoraja erinaceus (little skate)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
leri03420  Nucleotide excision repair
leri03420

Other DBs
GO: 0006289
Organism
Leucoraja erinaceus (little skate) [GN:leri]
Gene
129693955  gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
129694003  polr2a; LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
129694736  pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
129695012  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
129695187  ercc3; LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
129695335  gtf2h2; general transcription factor IIH subunit 2 [KO:K03142]
129695627  xpa; DNA repair protein complementing XP-A cells [KO:K10847]
129695917  ccnh; cyclin-H [KO:K06634]
129696699  ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
129696729  polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
129698024  rfc3; replication factor C subunit 3 [KO:K10756]
129698303  ercc5; DNA excision repair protein ERCC-5 [KO:K10846]
129698405  rfc1; replication factor C subunit 1 [KO:K10754]
129699577  gtf2h5; general transcription factor IIH subunit 5 isoform X1 [KO:K10845]
129700118  mnat1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
129700537  pole2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]
129700612  lig1; LOW QUALITY PROTEIN: DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
129701448  polr2b; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
129702066  cul4b; cullin-4B [KO:K10609]
129702182  cetn2; centrin-2 isoform X1 [KO:K10840]
129702764  [KO:K10609]
129703294  rfc4; replication factor C subunit 4 isoform X1 [KO:K10755]
129703484  polr2d; DNA-directed RNA polymerase II subunit RPB4 isoform X1 [KO:K03012]
129703622  polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]
129704266  [KO:K10840]
129704654  xpc; LOW QUALITY PROTEIN: DNA repair protein complementing XP-C cells [KO:K10838]
129705268  polr2c; DNA-directed RNA polymerase II subunit RPB3 isoform X1 [KO:K03011]
129705793  ddb1; DNA damage-binding protein 1 [KO:K10610]
129705803  gtf2h1; general transcription factor IIH subunit 1 isoform X1 [KO:K03141]
129707068  ercc4; LOW QUALITY PROTEIN: DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
129707165  uvssa; UV-stimulated scaffold protein A [KO:K23720]
129709238  gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]
129709308  rfc5; replication factor C subunit 5 [KO:K10756]
129709480  pole; LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
129709891  rpa2; replication protein A 32 kDa subunit [KO:K10739]
129710563  rpa1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
129710688  rfc2; replication factor C subunit 2 [KO:K10755]
129710728  polr2j; DNA-directed RNA polymerase II subunit RPB11-a isoform X1 [KO:K03008]
129711003  pole4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:2.7.7.7]
129711232  [KO:K10839]
129711307  polr2eb; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]
129712145  pole3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
129712643  polr2m; protein GRINL1A [KO:K21987]
129712878  ercc6; DNA excision repair protein ERCC-6 [KO:K10841]
129713175  [KO:K02328]
129713228  rpa3; replication protein A 14 kDa subunit [KO:K10740]
129713263  pcna; proliferating cell nuclear antigen [KO:K04802]
129713776  polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
129713814  polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]
129713871  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
129713982  pold1; LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
129714091  polr2i; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
129714095  ercc2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:5.6.2.3]
129714578  [KO:K10839]
129715507  polr2g; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
leri03020  RNA polymerase
leri04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

DBGET integrated database retrieval system