KEGG PATHWAY: lsr00260

PATHWAY: lsr00260

Entry

lsr00260                    Pathway

Name

Glycine, serine and threonine metabolism - Lonchura striata domestica (Bengalese finch)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

lsr00260

Glycine, serine and threonine metabolism

Module

lsr_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:lsr00260]

lsr_M00047

Creatine pathway [PATH:lsr00260]

lsr_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lsr00260]

lsr_M00555

Betaine biosynthesis, choline => betaine [PATH:lsr00260]

lsr_M00621

Glycine cleavage system [PATH:lsr00260]

lsr_M00974

Betaine metabolism, animals, betaine => glycine [PATH:lsr00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Lonchura striata domestica (Bengalese finch) [GN:lsr]

Gene

110472466

LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

110477069

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

110481486

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

110479650

AGXT; serine--pyruvate aminotransferase isoform X2 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

110482528

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

110472142

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

110473673

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

110482586

BPGM; bisphosphoglycerate mutase isoform X1 [KO:K01837] [EC:5.4.2.4 5.4.2.11]

110478936

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

110470684

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

110482038

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

110483799

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

110475992

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

110472195

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

110483987

5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]

110474872

amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]

110474874

amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

110471837

membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]

110471242

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]

110469958

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

110475187

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

110476346

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

110478188

DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

110482591

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

110474262

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

110480203

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

110472557

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

110467766

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

110470994

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

110470993

DMGDH; LOW QUALITY PROTEIN: dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

110482011

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

110477625

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

110472810

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

110479435

cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

110479436

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

110473255

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

110473256

cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

110468619

uncharacterized protein LOC110468619 isoform X1 [KO:K01754] [EC:4.3.1.19]

110481315

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

110482046

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721