Entry Name Pancreatic secretion - Mesocricetus auratus (golden hamster)
Description The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mesocricetus auratus (golden hamster) [GN:
maua ]
Gene 101825355 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
101842030 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101830949 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101834708 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101834401 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101841113 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
101833341 Ctrl; chymotrypsin-like protease CTRL-1 [KO:K09632 ] [EC:3.4.21.-]
101836776 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958 ]
101835945 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
101838704 Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
101830097 Clca4; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 4 [KO:K05030 ]
101830364 calcium-activated chloride channel regulator 3A-1-like isoform X1 [KO:K05030 ]
101835349 Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
101842599 Slc12a2; solute carrier family 12 member 2 isoform X1 [KO:K10951 ]
101828152 Atp1a3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539 ] [EC:7.2.2.13 ]
101844313 Atp1a2; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539 ] [EC:7.2.2.13 ]
101828802 Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
101833660 Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
101836917 Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540 ]
106021095 Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538 ]
101844599 Kcnq1; potassium voltage-gated channel subfamily KQT member 1 isoform X3 [KO:K04926 ]
101843799 Kcnma1; calcium-activated potassium channel subunit alpha-1 isoform X13 [KO:K04936 ]
101834728 Gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
101838304 Slc4a4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C13051 Nicotinic acid adenine dinucleotide phosphate
Reference Authors Petersen OH, Tepikin AV
Title Polarized calcium signaling in exocrine gland cells.
Journal Reference Authors Williams JA
Title Regulation of acinar cell function in the pancreas.
Journal Reference Authors Williams JA
Title Regulation of pancreatic acinar cell function.
Journal Reference Authors Bi Y, Williams JA
Title Receptor biology and signal transduction in pancreatic acinar cells.
Journal Reference Authors Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
Title Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Journal Reference Authors Kanno T
Title Ca2+ signaling in the pancreatic acinus.
Journal Pancreas 16:273-6 (1998)
Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
Title Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
Journal Reference Authors Chu JY, Yung WH, Chow BK
Title Secretin: a pleiotrophic hormone.
Journal Reference Authors Siu FK, Lam IP, Chu JY, Chow BK
Title Signaling mechanisms of secretin receptor.
Journal Reference Authors Steward MC, Ishiguro H, Case RM
Title Mechanisms of bicarbonate secretion in the pancreatic duct.
Journal Reference Authors Kim D, Steward MC
Title The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
Journal Reference Authors Whitcomb DC, Lowe ME
Title Human pancreatic digestive enzymes.
Journal Reference Authors Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
Title Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Journal Reference Authors Cancela JM, Churchill GC, Galione A
Title Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Journal Reference Authors Parekh AB
Title Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
Journal Reference Authors Williams JA, Chen X, Sabbatini ME
Title Small G proteins as key regulators of pancreatic digestive enzyme secretion.
Journal Related maua04973 Carbohydrate digestion and absorption
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