KEGG   PATHWAY: mcf04142
Entry
mcf04142                    Pathway                                
Name
Lysosome - Macaca fascicularis (crab-eating macaque)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcf04142  Lysosome
mcf04142

Other DBs
GO: 0005764
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102118312  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102127448  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
102118234  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101867133  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
102130688  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102143246  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
101926423  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102142621  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102138620  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
102134327  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102121430  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X3 [KO:K03661]
102119759  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
102119638  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
102142437  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
101866080  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
101866185  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
101865017  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
102125635  CTSD; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
102122689  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
102124998  CTSF; LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
102128983  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
102115935  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
102120416  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102116556  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102118013  LOW QUALITY PROTEIN: putative inactive cathepsin L-like protein CTSL3P [KO:K01365] [EC:3.4.22.15]
102123755  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
102131405  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
102120796  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
102134104  CTSV; LOW QUALITY PROTEIN: cathepsin L2 [KO:K01375] [EC:3.4.22.43]
102116663  CTSW; cathepsin W isoform X2 [KO:K08569] [EC:3.4.22.-]
102118566  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
102123120  NAPSA; napsin-A isoform X1 [KO:K08565] [EC:3.4.23.-]
102122749  napsin-A-like [KO:K08565] [EC:3.4.23.-]
101867471  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101867272  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
102124721  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
102119163  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
102141245  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
102121809  GBA; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
102116889  IDUA; alpha-L-iduronidase isoform X2 [KO:K01217] [EC:3.2.1.76]
102145379  NAGA; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
102121696  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
101925411  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
102142959  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
102137215  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
101866633  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
102118610  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
101925292  HEXA; beta-hexosaminidase subunit alpha isoform X4 [KO:K12373] [EC:3.2.1.52]
102140912  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
102137710  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
102138135  NEU1; sialidase-1 isoform X1 [KO:K01186] [EC:3.2.1.18]
102141387  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
107126372  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
102146623  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
102119956  LOW QUALITY PROTEIN: hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
102120586  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
101926741  SPAM1; hyaluronidase PH-20 isoform X2 [KO:K01197] [EC:3.2.1.35]
102115714  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
102116401  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
102118529  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
102118579  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
102145903  GNS; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
102137236  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
102142565  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
101926160  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
101925346  PLA2G15; phospholipase A2 group XV isoform X2 [KO:K06129] [EC:3.1.1.5]
102117817  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
102116438  DNASE2B; deoxyribonuclease-2-beta isoform X2 [KO:K01158] [EC:3.1.22.1]
101864829  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
102116477  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
102136513  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
102118393  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
101866403  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X3 [KO:K01444] [EC:3.5.1.26]
102141446  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
101866922  prosaposin isoform X1 [KO:K12382]
102143555  GM2A; ganglioside GM2 activator [KO:K12383]
102124313  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
102126191  PPT1; palmitoyl-protein thioesterase 1 isoform X2 [KO:K01074] [EC:3.1.2.22]
101867227  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
102119735  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
102117675  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
102132218  CD68; macrosialin [KO:K06501]
102132387  CD63; CD63 antigen isoform X1 [KO:K06497]
101865648  SCARB2; lysosome membrane protein 2 [KO:K12384]
102123618  NPC1; NPC intracellular cholesterol transporter 1 isoform X2 [KO:K12385]
101865784  NPC2; NPC intracellular cholesterol transporter 2 isoform X2 [KO:K13443]
102140046  CTNS; cystinosin isoform X1 [KO:K12386]
101925314  SLC17A5; sialin isoform X1 [KO:K12301]
102116772  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
101865397  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
101867509  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
101925752  LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
123575244  LAPTM4B; LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387]
102121803  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
102119591  ABCB9; ABC-type oligopeptide transporter ABCB9 isoform X2 [KO:K05656]
102136974  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
102139183  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
102123074  SORT1; sortilin isoform X1 [KO:K12388]
101925740  CLN3; battenin isoform X1 [KO:K12389]
102126341  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
102145540  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
102129964  HGSNAT; LOW QUALITY PROTEIN: heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
102118800  SUMF1; formylglycine-generating enzyme isoform X2 [KO:K13444] [EC:1.8.3.7]
102121493  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
102144532  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
102127868  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
102117130  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101866280  M6PR; cation-dependent mannose-6-phosphate receptor isoform X3 [KO:K10089]
102127034  CLTA; clathrin light chain A isoform X1 [KO:K04644]
102141474  CLTB; clathrin light chain B isoform X1 [KO:K04645]
101866855  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101866864  CLTCL1; clathrin heavy chain 2 isoform X2 [KO:K04646]
102120926  AP1G2; AP-1 complex subunit gamma-like 2 isoform X4 [KO:K12391]
101865923  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
102143866  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
102141131  AP1M1; AP-1 complex subunit mu-1 isoform X2 [KO:K12393]
102114955  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
102114826  AP1S1; AP-1 complex subunit sigma-1A isoform X2 [KO:K12394]
102132905  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
102141447  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
101926733  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
102121407  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
101926323  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
102144600  AP3M2; AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
101864849  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
102143290  AP3S1; AP-3 complex subunit sigma-1 isoform X3 [KO:K12399]
102116051  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
102144702  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
101925391  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
101866534  AP4M1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
102118592  AP-4 complex subunit sigma-1 [KO:K12403]
101926827  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
102128394  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
102114927  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
102146154  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
102143748  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
102137349  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mcf00511  Other glycan degradation
mcf00531  Glycosaminoglycan degradation
mcf04130  SNARE interactions in vesicular transport
mcf04140  Autophagy - animal
mcf04144  Endocytosis
KO pathway
ko04142   
LinkDB

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