KEGG   PATHWAY: mcf04144
Entry
mcf04144                    Pathway                                
Name
Endocytosis - Macaca fascicularis (crab-eating macaque)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcf04144  Endocytosis
mcf04144

Other DBs
GO: 0006897
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102132075  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101925607  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8 [KO:K00889] [EC:2.7.1.68]
101865406  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
102133242  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102143136  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
102143827  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
102132109  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
102130012  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
102135212  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
102130665  DNM1; dynamin-1 isoform X4 [KO:K01528] [EC:3.6.5.5]
102118932  DNM2; dynamin-2 isoform X2 [KO:K23484] [EC:3.6.5.5]
102127034  CLTA; clathrin light chain A isoform X1 [KO:K04644]
102141474  CLTB; clathrin light chain B isoform X1 [KO:K04645]
101866855  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
101866864  CLTCL1; clathrin heavy chain 2 isoform X2 [KO:K04646]
102145764  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
102147319  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101926562  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
102131193  AP2M1; AP-2 complex subunit mu [KO:K11826]
102146396  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101867058  EHD2; EH domain-containing protein 2 [KO:K12469]
102115287  TGFBR1; TGF-beta receptor type-1 isoform X4 [KO:K04674] [EC:2.7.11.30]
102134273  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102120040  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X2 [KO:K04679]
102131909  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
102135847  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101925163  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102146086  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
102136007  TFRC; transferrin receptor protein 1 [KO:K06503]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102138392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102143086  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102128947  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102118990  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102137660  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
102114949  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
102135911  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X2 [KO:K22518] [EC:2.3.2.27]
102127625  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X2 [KO:K12470]
102146996  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
102129751  SH3GL2; endophilin-A1 isoform X2 [KO:K11247]
101865840  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
101926561  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
102135469  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
101926283  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
102127478  amphiphysin isoform X1 [KO:K12562]
102141143  EPN1; epsin-1 isoform X1 [KO:K12471]
102137803  EPN3; epsin-3 isoform X1 [KO:K12471]
102129885  EPN2; epsin-2 isoform X1 [KO:K12471]
102141791  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
101865137  EPS15; epidermal growth factor receptor substrate 15 isoform X4 [KO:K12472]
102125804  SPART; spartin [KO:K19366]
102142897  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101867463  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X18 [KO:K13305] [EC:2.3.2.26]
102136323  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102126112  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
101925768  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
102126087  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X5 [KO:K04678] [EC:2.3.2.26]
102123469  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
101865249  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2 [KO:K05633] [EC:2.3.2.26]
102127361  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102127818  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
102139456  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102140902  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
102139639  C-X-C chemokine receptor type 2 [KO:K05050]
102142487  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
102133613  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102131074  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102141926  GRK3; G protein-coupled receptor kinase 3 isoform X1 [KO:K00910] [EC:2.7.11.15]
102141861  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
102115240  GRK4; G protein-coupled receptor kinase 4 isoform X17 [KO:K08291] [EC:2.7.11.16]
102128844  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
102132362  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
102125783  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
101925869  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101866800  WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
102117163  ACTR2; actin-related protein 2 [KO:K17260]
102134164  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102146785  ACTR3; actin-related protein 3 [KO:K18584]
101926790  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101866811  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
102142497  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101925123  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102135583  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
101865459  LOW QUALITY PROTEIN: putative uncharacterized protein encoded by LINC00467 homolog [KO:K05756]
102117320  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X3 [KO:K05755]
101866570  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101867382  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102115869  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
102117482  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
102130156  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
102118053  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
102143176  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101925240  heat shock 70 kDa protein 1A [KO:K03283]
102131294  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101926012  HSPA1L; heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
123572795  heat shock 70 kDa protein 1A [KO:K03283]
101865909  DNAJC6; auxilin isoform X4 [KO:K09526]
102116877  WASHC4; WASH complex subunit 4 isoform X2 [KO:K18465]
101864879  WASHC5; WASH complex subunit 5 [KO:K18464]
102115201  WASHC2C; WASH complex subunit 2A isoform X3 [KO:K18462]
102144060  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
102124959  WASHC3; WASH complex subunit 3 isoform X2 [KO:K18463]
101866335  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
101925111  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
101926750  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101866643  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
102141828  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
102139525  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
101866416  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
101926811  vacuolar protein sorting-associated protein 35 isoform X6 [KO:K18468]
101925791  SNX12; sorting nexin-12 [KO:K17918]
102128152  SNX3; sorting nexin-3 [KO:K17918]
101926489  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
102116269  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
102143515  RAB7A; ras-related protein Rab-7a [KO:K07897]
102130302  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
102127970  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
102117972  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101866060  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
102136996  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
102134393  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
102127199  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
102144748  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
102116881  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
102141753  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
102142247  VPS37C; vacuolar protein sorting-associated protein 37C isoform X2 [KO:K12185]
102117548  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
102120944  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
102129767  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
102140839  CHMP6; charged multivesicular body protein 6 [KO:K12195]
135969763  charged multivesicular body protein 4A-like [KO:K12194]
102147247  CHMP4B; charged multivesicular body protein 4B [KO:K12194]
102146840  CHMP4A; charged multivesicular body protein 4a isoform X1 [KO:K12194]
102120300  CHMP4C; charged multivesicular body protein 4C [KO:K24782]
102131403  charged multivesicular body protein 3 isoform X3 [KO:K12193]
102142325  CHMP2A; charged multivesicular body protein 2A [KO:K12191]
102117106  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
102136921  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
102117132  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
102137049  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
102130600  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
102137440  CHMP1B; charged multivesicular body protein 1B [KO:K12197]
102126892  CHMP1A; charged multivesicular body protein 1A [KO:K12197]
102129367  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101865959  IST1; IST1 homolog isoform X4 [KO:K19476]
102142022  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
101866571  SPG21; maspardin [KO:K19367]
102117130  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
102136250  SNX1; sorting nexin-1 isoform X2 [KO:K17917]
101925814  SNX2; sorting nexin-2 [KO:K17917]
101864875  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
101926444  SNX6; sorting nexin-6 isoform X2 [KO:K17920]
101925421  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102118744  HRAS; GTPase HRas [KO:K02833]
102123605  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102138714  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
102144912  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101865630  RHOA; transforming protein RhoA [KO:K04513]
135970336  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X5 [KO:K06751]
135970333  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
135970331  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
135970329  HLA class I histocompatibility antigen, B alpha chain isoform X1 [KO:K06751]
135964326  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
135970341  popy class I histocompatibility antigen, alpha chain E-like isoform X4 [KO:K06751]
135970343  LOW QUALITY PROTEIN: putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
135970345  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
102122138  MAFA-F; mamu class I histocompatibility antigen, alpha chain F precursor [KO:K06751]
102138874  popy class I histocompatibility antigen, alpha chain E isoform 1 precursor [KO:K06751]
102141835  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
102123548  class I histocompatibility antigen, Gogo-B*0103 alpha chain precursor [KO:K06751]
102117143  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-1 alpha chain [KO:K06751]
102120132  class I histocompatibility antigen, Gogo-B*0101 alpha chain precursor [KO:K06751]
102140002  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0103 alpha chain [KO:K06751]
102116527  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X4 [KO:K06751]
135967064  folate receptor gamma [KO:K13649]
102132686  LOW QUALITY PROTEIN: folate receptor gamma-like [KO:K13649]
102132305  FOLR1; folate receptor alpha [KO:K13649]
102147063  FOLR2; folate receptor beta isoform X1 [KO:K13649]
101865646  CAV1; caveolin-1 isoform X2 [KO:K06278]
102122005  CAV2; caveolin-2 isoform X1 [KO:K12958]
102133753  CAV3; caveolin-3 [KO:K12959]
102118483  EHD3; EH domain-containing protein 3 [KO:K12476]
102143436  EHD4; EH domain-containing protein 4 [KO:K12477]
101926553  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
102144117  RAB5A; ras-related protein Rab-5A [KO:K07887]
101865961  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
102116190  RAB5C; ras-related protein Rab-5C [KO:K07889]
102115557  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
102122641  RBSN; rabenosyn-5 [KO:K12481]
102122190  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
102135209  RUFY1; RUN and FYVE domain-containing protein 1 isoform X3 [KO:K12482]
102122974  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
101926234  EHD1; EH domain-containing protein 1 [KO:K12483]
101867265  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101865024  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
102138845  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
102129674  RAB31; ras-related protein Rab-31 [KO:K07891]
102115007  RAB10; ras-related protein Rab-10 [KO:K07903]
102139595  RAB8A; ras-related protein Rab-8A [KO:K07901]
102136603  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
101925291  RAB11A; ras-related protein Rab-11A [KO:K07904]
101926365  RAB11B; ras-related protein Rab-11B [KO:K07905]
102122733  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
102131571  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
102125880  RAB11FIP5; rab11 family-interacting protein 5 isoform X4 [KO:K12484]
102128891  ZFYVE27; protrudin isoform X1 [KO:K19368]
101865454  KIF5A; kinesin heavy chain [KO:K10396]
102140196  KIF5B; kinesin-1 heavy chain [KO:K10396]
102128569  KIF5C; kinesin heavy chain [KO:K10396]
102146645  RAB11FIP3; rab11 family-interacting protein 3 isoform X2 [KO:K12485]
102144715  RAB11FIP4; rab11 family-interacting protein 4 isoform X2 [KO:K12485]
102114934  PARD3; partitioning defective 3 homolog isoform X21 [KO:K04237]
102133257  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102146526  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
102125568  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101925905  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102115718  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102125726  cell division control protein 42 homolog [KO:K04393]
102124817  cell division control protein 42 homolog [KO:K04393]
102123195  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
102117004  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
101865336  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
102127879  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
102128760  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12488]
102143982  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
102120139  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12488]
102139565  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
102133098  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5 [KO:K12489]
102119287  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
102118991  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
102125500  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K18440]
102124624  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
102137947  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like [KO:K12491]
101925511  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X5 [KO:K12491]
102119037  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like [KO:K12491]
102142032  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 [KO:K12491]
102140657  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6 [KO:K12491]
102116754  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K17848]
102124149  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
102127149  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
101866546  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
102145436  PSD2; PH and SEC7 domain-containing protein 2 isoform X3 [KO:K12494]
102124794  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
102123591  PSD3; PH and SEC7 domain-containing protein 3 isoform X2 [KO:K12494]
101865718  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
102130177  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X9 [KO:K12495]
102136589  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
102123206  CYTH1; cytohesin-1 isoform X2 [KO:K18441]
102136691  CYTH4; cytohesin-4 [KO:K18441]
102145146  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
102147001  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101866900  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
102118309  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
101865219  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5 [KO:K18443]
101926228  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
102115409  ADP-ribosylation factor 1-like [KO:K07937]
102145963  ADP-ribosylation factor 1-like [KO:K07937]
102120213  ARF3; ADP-ribosylation factor 3 isoform X1 [KO:K07938]
101866149  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
102126655  ADP-ribosylation factor 4-like [KO:K07939]
101865072  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mcf04060  Cytokine-cytokine receptor interaction
mcf04070  Phosphatidylinositol signaling system
mcf04130  SNARE interactions in vesicular transport
mcf04142  Lysosome
mcf04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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