KEGG   PATHWAY: mlf00260
Entry
mlf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Myotis lucifugus (little brown bat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mlf00260  Glycine, serine and threonine metabolism
mlf00260

Module
mlf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mlf00260]
mlf_M00047  Creatine pathway [PATH:mlf00260]
mlf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mlf00260]
mlf_M00555  Betaine biosynthesis, choline => betaine [PATH:mlf00260]
mlf_M00621  Glycine cleavage system [PATH:mlf00260]
mlf_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mlf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102418889  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
102441477  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X2 [KO:K00600] [EC:2.1.2.1]
102416821  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102427587  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102420981  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
102435092  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
102432217  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
102437274  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
102420891  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102425002  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
102422165  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
102425080  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
102431306  LOW QUALITY PROTEIN: L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
102435732  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
102432191  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
102422599  ALAS2; LOW QUALITY PROTEIN: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
102429402  MAOA; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
102429703  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
102439874  AOC3; membrane primary amine oxidase isoform X5 [KO:K00276] [EC:1.4.3.21]
102439128  AOC2; retina-specific copper amine oxidase isoform X2 [KO:K00276] [EC:1.4.3.21]
102422643  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
102423671  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
102438609  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
102435920  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
102432979  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
102424294  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102437970  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
102424140  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
102432547  CHDH; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
102441975  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102425902  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
102426434  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
102434938  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
102442398  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
102433635  CBS; LOW QUALITY PROTEIN: cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
102418273  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
102431813  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
102436550  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
102434001  SRR; serine racemase isoform X2 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mlf00010  Glycolysis / Gluconeogenesis
mlf00020  Citrate cycle (TCA cycle)
mlf00230  Purine metabolism
mlf00250  Alanine, aspartate and glutamate metabolism
mlf00270  Cysteine and methionine metabolism
mlf00290  Valine, leucine and isoleucine biosynthesis
mlf00330  Arginine and proline metabolism
mlf00470  D-Amino acid metabolism
mlf00564  Glycerophospholipid metabolism
mlf00600  Sphingolipid metabolism
mlf00620  Pyruvate metabolism
mlf00630  Glyoxylate and dicarboxylate metabolism
mlf00640  Propanoate metabolism
mlf00860  Porphyrin metabolism
mlf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system