KEGG   PATHWAY: mlf00230
Entry
mlf00230                    Pathway                                
Name
Purine metabolism - Myotis lucifugus (little brown bat)
Class
Metabolism; Nucleotide metabolism
Pathway map
mlf00230  Purine metabolism
mlf00230

Module
mlf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mlf00230]
mlf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mlf00230]
mlf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mlf00230]
mlf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mlf00230]
mlf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mlf00230]
mlf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mlf00230]
mlf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mlf00230]
Other DBs
GO: 0006163 0042278
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102441479  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
102438238  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102418798  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102440695  PGM1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
102425236  PGM2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102424552  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
102424322  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
102437276  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
102437604  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
102424778  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102437947  PFAS; LOW QUALITY PROTEIN: phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
102437295  PAICS; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102433913  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
102439913  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102428091  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102419112  NT5C2; cytosolic purine 5'-nucleotidase isoform X3 [KO:K01081] [EC:3.1.3.5]
102430318  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102428652  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
102438549  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102427533  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102434837  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102422263  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102428842  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102441052  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
102435303  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
102433130  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
102433716  LOW QUALITY PROTEIN: nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
102428823  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
102420296  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
102441047  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
106699533  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
102421724  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
102426895  adenylate kinase 9-like [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102443033  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102437086  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
102442174  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102425478  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X5 [KO:K12305] [EC:3.6.1.6]
102419532  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
102432978  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X3 [KO:K01511] [EC:3.6.1.6]
102437955  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102435752  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
102441222  XDH; xanthine dehydrogenase/oxidase isoform X2 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102429432  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
102438313  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X2 [KO:K01951] [EC:6.3.5.2]
102437195  GMPR; LOW QUALITY PROTEIN: GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
102421427  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
102418000  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102426530  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
102423105  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
102418042  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102426860  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102434284  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
102424325  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
102435442  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102429689  HDDC3; LOW QUALITY PROTEIN: guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
102443118  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
102430354  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
102442682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102417969  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102425254  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102433159  ADCY6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102423495  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102422477  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102420579  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
102417646  GUCY1A1; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
102429123  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102428541  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102442918  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
102435698  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
102430842  LOW QUALITY PROTEIN: olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
102435067  GUCY2D; LOW QUALITY PROTEIN: retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
102418083  GUCY2F; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
102441815  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
102439662  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
102425391  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
102439889  PDE1B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102431768  PDE1C; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102427182  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102437721  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
102442246  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
102431150  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102430691  cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
102417793  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
102442775  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
102429948  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
106695596  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102438472  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
102428654  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
102417131  PDE10A; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102436727  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102426354  ADSS; LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
102431067  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
102440284  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
102435120  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
102431790  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
102425830  ADA2; LOW QUALITY PROTEIN: adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
102420674  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102439111  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
102423359  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102417350  adenylate kinase 4, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
102423114  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102442979  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
102417452  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
106694321  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
102418681  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
102426154  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
102427592  ENPP1; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102442736  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102417220  PDE4D; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102430661  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
102418757  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
102433009  PDE4A; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
102418516  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
102421883  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102430775  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
102428868  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like [KO:K18437] [EC:3.1.4.53]
102438722  LOW QUALITY PROTEIN: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like [KO:K18437] [EC:3.1.4.53]
102439181  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
102428370  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
102421956  bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
102422507  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
102440925  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102433995  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102440467  uricase [KO:K00365] [EC:1.7.3.3]
102433439  5-hydroxyisourate hydrolase-like isoform X2 [KO:K07127] [EC:3.5.2.17]
102443229  URAD; LOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
102417397  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mlf00030  Pentose phosphate pathway
mlf00220  Arginine biosynthesis
mlf00250  Alanine, aspartate and glutamate metabolism
mlf00260  Glycine, serine and threonine metabolism
mlf00340  Histidine metabolism
mlf00630  Glyoxylate and dicarboxylate metabolism
mlf00730  Thiamine metabolism
mlf00740  Riboflavin metabolism
mlf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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