KEGG   PATHWAY: mmu00330
Entry
mmu00330                    Pathway                                
Name
Arginine and proline metabolism - Mus musculus (house mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
mmu00330  Arginine and proline metabolism
mmu00330

Module
mmu_M00015  Proline biosynthesis, glutamate => proline [PATH:mmu00330]
mmu_M00047  Creatine pathway [PATH:mmu00330]
mmu_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:mmu00330]
mmu_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:mmu00330]
mmu_M00970  Proline degradation, proline => glutamate [PATH:mmu00330]
mmu_M00972  Proline metabolism [PATH:mmu00330]
Other DBs
GO: 0006525 0006560
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041585  Amd2; S-adenosylmethionine decarboxylase 2 [KO:K01611] [EC:4.1.1.50]
107239  Carns1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
109731  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
11702  Amd1; S-adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
11846  Arg1; arginase, liver [KO:K01476] [EC:3.5.3.1]
11847  Arg2; arginase type II [KO:K01476] [EC:3.5.3.1]
12709  Ckb; creatine kinase, brain [KO:K00933] [EC:2.7.3.2]
12715  Ckm; creatine kinase, muscle [KO:K27382]
12716  Ckmt1; creatine kinase, mitochondrial 1, ubiquitous [KO:K00933] [EC:2.7.3.2]
13142  Dao; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
14431  Gamt; guanidinoacetate methyltransferase [KO:K00542] [EC:2.1.1.2]
14718  Got1; glutamic-oxaloacetic transaminase 1, soluble [KO:K14454] [EC:2.6.1.1]
14719  Got2; glutamatic-oxaloacetic transaminase 2, mitochondrial [KO:K14455] [EC:2.6.1.1]
17161  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
18127  Nos3; nitric oxide synthase 3, endothelial cell [KO:K13242] [EC:1.14.13.39]
18242  Oat; ornithine aminotransferase [KO:K00819] [EC:2.6.1.13]
18263  Odc1; ornithine decarboxylase, structural 1 [KO:K01581] [EC:4.1.1.17]
18451  P4ha1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide [KO:K00472] [EC:1.14.11.2]
18452  P4ha2; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide [KO:K00472] [EC:1.14.11.2]
19125  Prodh; proline dehydrogenase [KO:K00318] [EC:1.5.5.2]
20229  Sat1; spermidine/spermine N1-acetyl transferase 1 [KO:K00657] [EC:2.3.1.57]
20603  Sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
20810  Srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
209027  Pycr1; pyrroline-5-carboxylate reductase 1 [KO:K00286] [EC:1.5.1.2]
212647  Aldh4a1; aldehyde dehydrogenase 4 family, member A1 [KO:K00294] [EC:1.2.1.88]
228608  Smox; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
242669  Azin2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
243376  Aoc1l1; amine oxidase copper containing 1-like 1 [KO:K11182] [EC:1.4.3.22]
243377  Aoc1l3; amine oxidase copper containing 1-like 3 [KO:K11182] [EC:1.4.3.22]
320452  P4ha3; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III [KO:K00472] [EC:1.14.11.2]
332942  Ldc1; leucine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
338403  Cndp1; carnosine dipeptidase 1 [KO:K05604] [EC:3.4.13.20]
56189  Prodh2; proline dehydrogenase (oxidase) 2 [KO:K11394] [EC:1.5.5.3]
56454  Aldh18a1; aldehyde dehydrogenase 18 family, member A1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
66054  Cndp2; CNDP dipeptidase 2 [KO:K08660] [EC:3.4.13.18]
66194  Pycr3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
66988  Lap3; leucine aminopeptidase 3 [KO:K11142] [EC:3.4.11.1 3.4.11.5]
67092  Gatm; glycine amidinotransferase (L-arginine:glycine amidinotransferase) [KO:K00613] [EC:2.1.4.1]
67217  L3hypdh; L-3-hydroxyproline dehydratase (trans-) [KO:K18384] [EC:4.2.1.77]
67432  Hoga1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
69051  Pycr2; pyrroline-5-carboxylate reductase family, member 2 [KO:K00286] [EC:1.5.1.2]
69215  Sat2; spermidine/spermine N1-acetyl transferase 2 [KO:K00657] [EC:2.3.1.57]
69761  Aoc1l2; amine oxidase copper containing 1-like 2 [KO:K11182] [EC:1.4.3.22]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
75986  Agmat; agmatinase [KO:K27001]
76507  Aoc1; amine oxidase, copper-containing 1 [KO:K11182] [EC:1.4.3.22]
76615  Got1l1; glutamic-oxaloacetic transaminase 1-like 1 [KO:K14454] [EC:2.6.1.1]
76722  Ckmt2; creatine kinase, mitochondrial 2 [KO:K00933] [EC:2.7.3.2]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00220  Arginine biosynthesis
mmu00250  Alanine, aspartate and glutamate metabolism
mmu00260  Glycine, serine and threonine metabolism
mmu00270  Cysteine and methionine metabolism
mmu00310  Lysine degradation
mmu00410  beta-Alanine metabolism
mmu00470  D-Amino acid metabolism
mmu00480  Glutathione metabolism
mmu00630  Glyoxylate and dicarboxylate metabolism
mmu00650  Butanoate metabolism
mmu00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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