KEGG PATHWAY: mmu00260

PATHWAY: mmu00260

Entry

mmu00260                    Pathway

Name

Glycine, serine and threonine metabolism - Mus musculus (house mouse)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mmu00260

Glycine, serine and threonine metabolism

Module

mmu_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mmu00260]

mmu_M00047

Creatine pathway [PATH:mmu00260]

mmu_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmu00260]

mmu_M00555

Betaine biosynthesis, choline => betaine [PATH:mmu00260]

mmu_M00621

Glycine cleavage system [PATH:mmu00260]

mmu_M00974

Betaine metabolism, animals, betaine => glycine [PATH:mmu00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Mus musculus (house mouse) [GN:mmu]

Gene

100678

Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

104174

Gldc; glycine decarboxylase [KO:K00281] [EC:1.4.4.2]

107272

Psat1; phosphoserine aminotransferase 1 [KO:K00831] [EC:2.6.1.52]

107869

Cth; cystathionine gamma lyase [KO:K01758] [EC:4.4.1.1]

108037

Shmt2; serine hydroxymethyltransferase 2 (mitochondrial) [KO:K00600] [EC:2.1.2.1]

109731

Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]

110695

Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

11611

Agxt; alanine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

11655

Alas1; aminolevulinic acid synthase 1 [KO:K00643] [EC:2.3.1.37]

11656

Alas2; aminolevulinic acid synthase 2, erythroid [KO:K00643] [EC:2.3.1.37]

11754

Aoc3; amine oxidase, copper containing 3 [KO:K00276] [EC:1.4.3.21]

12116

Bhmt; betaine-homocysteine methyltransferase [KO:K00544] [EC:2.1.1.5]

12183

Bpgm; 2,3-bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

12411

Cbs; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

13142

Dao; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]

13382

Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

14431

Gamt; guanidinoacetate methyltransferase [KO:K00542] [EC:2.1.1.2]

14711

Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

17161

Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

18648

Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

19193

Pipox; pipecolic acid oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

192166

Sardh; sarcosine dehydrogenase [KO:K00314] [EC:1.5.8.3]

20425

Shmt1; serine hydroxymethyltransferase 1 (soluble) [KO:K00600] [EC:2.1.2.1]

218865

Chdh; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

231691

Sds; serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

235582

Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]

236539

Phgdh; 3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

237940

Aoc2; amine oxidase copper containing 2 [KO:K00276] [EC:1.4.3.21]

257635

Sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

268782

Agxt2; alanine-glyoxylate aminotransferase 2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

26912

Gcat; glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) [KO:K00639] [EC:2.3.1.29]

27364

Srr; serine racemase [KO:K12235] [EC:5.1.1.18]

434437

Amt; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]

56012

Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

58865

Tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]

67092

Gatm; glycine amidinotransferase (L-arginine:glycine amidinotransferase) [KO:K00613] [EC:2.1.4.1]

68133

Gcsh; glycine cleavage system protein H (aminomethyl carrier) [KO:K02437]

71776

Tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]

74129

Dmgdh; dimethylglycine dehydrogenase precursor [KO:K00315] [EC:1.5.8.4]

76238

Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721