KEGG   PATHWAY: mmu00310
Entry
mmu00310                    Pathway                                
Name
Lysine degradation - Mus musculus (house mouse)
Class
Metabolism; Amino acid metabolism
Pathway map
mmu00310  Lysine degradation
mmu00310

Module
mmu_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:mmu00310]
Other DBs
GO: 0006554
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
107303348  Gm45935; predicted gene, 45935 [KO:K18494] [EC:2.1.1.355]
107823  Nsd2; nuclear receptor binding SET domain protein 2 [KO:K11424] [EC:2.1.1.357]
110147  Ehmt2; euchromatic histone lysine N-methyltransferase 2 [KO:K11420] [EC:2.1.1.355]
110446  Acat1; acetyl-Coenzyme A acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
110460  Acat2; acetyl-Coenzyme A acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
110593  Prdm2; PR domain containing 2, with ZNF domain [KO:K11432] [EC:2.1.1.355]
110695  Aldh7a1; aldehyde dehydrogenase family 7, member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
11669  Aldh2; aldehyde dehydrogenase 2, mitochondrial [KO:K00128] [EC:1.2.1.3]
11671  Aldh3a2; aldehyde dehydrogenase family 3, subfamily A2 [KO:K00128] [EC:1.2.1.3]
12180  Smyd1; SET and MYND domain containing 1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
13382  Dld; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
14013  Mecom; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
14055  Ezh1; enhancer of zeste 1 polycomb repressive complex 2 subunit [KO:K17451] [EC:2.1.1.356]
14056  Ezh2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
15107  Hadh; hydroxyacyl-Coenzyme A dehydrogenase [KO:K00022] [EC:1.1.1.35]
170442  Bbox1; gamma-butyrobetaine hydroxylase 1 [KO:K00471] [EC:1.14.11.1]
18193  Nsd1; nuclear receptor-binding SET-domain protein 1 [KO:K15588] [EC:2.1.1.357]
18822  Plod1; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
19193  Pipox; pipecolic acid oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
192195  Ash1l; ASH1 like histone lysine methyltransferase [KO:K06101] [EC:2.1.1.354]
192289  Tmlhe; trimethyllysine hydroxylase, epsilon [KO:K00474] [EC:1.14.11.8]
208043  Setd1b; SET domain containing 1B [KO:K11422] [EC:2.1.1.354]
208266  Dot1l; DOT1 like histone lysine methyltransferase [KO:K11427] [EC:2.1.1.360]
20937  Suv39h1; suppressor of variegation 3-9 1 [KO:K11419] [EC:2.1.1.355]
209692  Dhtkd1; dehydrogenase E1 and transketolase domain containing 1 [KO:K15791] [EC:1.2.4.-]
213389  Prdm9; PR domain containing 9 [KO:K20796] [EC:2.1.1.354]
214162  Kmt2a; lysine (K)-specific methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
224530  Acat3; acetyl-Coenzyme A acetyltransferase 3 [KO:K00626] [EC:2.3.1.9]
225518  Prdm6; PR domain containing 6 [KO:K20795] [EC:2.1.1.361]
225888  Kmt5b; lysine methyltransferase 5B [KO:K11429] [EC:2.1.1.362]
226830  Smyd2; SET and MYND domain containing 2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
231051  Kmt2c; lysine (K)-specific methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
232811  Kmt5c; lysine methyltransferase 5C [KO:K11429] [EC:2.1.1.362]
233904  Setd1a; SET domain containing 1A [KO:K11422] [EC:2.1.1.354]
234135  Nsd3; nuclear receptor binding SET domain protein 3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
234407  Colgalt1; collagen beta(1-O)galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
235386  Hykk; hydroxylysine kinase 1 [KO:K18201] [EC:2.7.1.81]
235626  Setd2; SET domain containing 2 [KO:K11423] [EC:2.1.1.359]
239122  Setdb2; SET domain, bifurcated 2 [KO:K18494] [EC:2.1.1.355]
23923  Aadat; aminoadipate aminotransferase [KO:K00825] [EC:2.6.1.7 2.6.1.39]
26432  Plod2; procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [KO:K13645] [EC:1.14.11.4]
26433  Plod3; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
269132  Colgalt2; collagen beta(1-O)galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
270076  Gcdh; glutaryl-Coenzyme A dehydrogenase [KO:K00252] [EC:1.3.8.6]
30956  Aass; aminoadipate-semialdehyde synthase [KO:K14157] [EC:1.5.1.8 1.5.1.9]
381022  Kmt2d; lysine (K)-specific methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
56752  Aldh9a1; aldehyde dehydrogenase 9, subfamily A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
64707  Suv39h2; suppressor of variegation 3-9 2 [KO:K11419] [EC:2.1.1.355]
67956  Kmt5a; lysine methyltransferase 5A [KO:K11428] [EC:2.1.1.361]
69188  Kmt2e; lysine (K)-specific methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
69726  Smyd3; SET and MYND domain containing 3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
70673  Prdm16; PR domain containing 16 [KO:K22410] [EC:2.1.1.367]
72535  Aldh1b1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
72947  Phykpl; 5-phosphohydroxy-L-lysine phospholyase [KO:K18202] [EC:4.2.3.134]
73251  Setd7; SET domain containing (lysine methyltransferase) 7 [KO:K11431] [EC:2.1.1.364]
73582  Camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
74147  Ehhadh; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
74729  Setmar; SET domain without mariner transposase fusion [KO:K11433] [EC:2.1.1.357]
75410  Kmt2b; lysine (K)-specific methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
77683  Ehmt1; euchromatic histone methyltransferase 1 [KO:K11420] [EC:2.1.1.355]
78920  Dlst; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]
84505  Setdb1; SET domain, bifurcated 1 [KO:K11421] [EC:2.1.1.366]
93747  Echs1; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial [KO:K07511] [EC:4.2.1.17]
97212  Hadha; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
mmu00020  Citrate cycle (TCA cycle)
mmu00780  Biotin metabolism
KO pathway
ko00310   

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