KEGG   PATHWAY: mmu04612
Entry
mmu04612                    Pathway                                
Name
Antigen processing and presentation - Mus musculus (house mouse)
Class
Organismal Systems; Immune system
Pathway map
mmu04612  Antigen processing and presentation
mmu04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100504404  H2-Ea; histocompatibility 2, class II antigen E alpha [KO:K06752]
100529082  H2-T27; histocompatibility 2, T region locus 27 [KO:K06751]
108802  Calr4; calreticulin 4 [KO:K08057]
110557  H2-Q6; histocompatibility 2, Q region locus 6 [KO:K06751]
110558  H2-Q9; histocompatibility 2, Q region locus 9 [KO:K06751]
110696  H2-M10.3; histocompatibility 2, M region locus 10.3 [KO:K06751]
12010  B2m; beta-2 microglobulin [KO:K08055]
12265  Ciita; class II transactivator [KO:K08060] [EC:2.7.11.1]
12317  Calr; calreticulin [KO:K08057]
12330  Canx; calnexin [KO:K08054]
12504  Cd4; CD4 antigen [KO:K06454]
12525  Cd8a; CD8 subunit alpha [KO:K06458]
12526  Cd8b1; CD8 subunit beta 1 [KO:K06459]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
13030  Ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
13039  Ctsl; cathepsin L [KO:K01365] [EC:3.4.22.15]
13040  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
14827  Pdia3; protein disulfide isomerase associated 3 [KO:K08056] [EC:5.3.4.1]
14828  Hspa5; heat shock protein 5 [KO:K09490] [EC:3.6.4.10]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14963  H2-Bl; histocompatibility 2, blastocyst [KO:K06751]
14964  H2-D1; histocompatibility 2, D region locus 1 [KO:K06751]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14972  H2-K1; histocompatibility 2, K1, K region [KO:K06751]
14980  H2-L; histocompatibility 2, D region locus L [KO:K06751]
14985  H2-M10.1; histocompatibility 2, M region locus 10.1 [KO:K06751]
14990  H2-M2; histocompatibility 2, M region locus 2 [KO:K06751]
14991  H2-M3; histocompatibility 2, M region locus 3 [KO:K06751]
14997  H2-M9; histocompatibility 2, M region locus 9 [KO:K06751]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
15006  H2-Q1; histocompatibility 2, Q region locus 1 [KO:K06751]
15007  H2-Q10; histocompatibility 2, Q region locus 10 [KO:K06751]
15013  H2-Q2; histocompatibility 2, Q region locus 2 [KO:K06751]
15015  H2-Q4; histocompatibility 2, Q region locus 4 [KO:K06751]
15018  H2-Q7; histocompatibility 2, Q region locus 7 [KO:K06751]
15024  H2-T10; histocompatibility 2, T region locus 10 [KO:K06751]
15039  H2-T22; histocompatibility 2, T region locus 22 [KO:K06751]
15040  H2-T23; histocompatibility 2, T region locus 23 [KO:K06751]
15042  H2-T24; histocompatibility 2, T region locus 24 [KO:K06751]
15043  H2-T3; histocompatibility 2, T region locus 3 [KO:K06751]
15481  Hspa8; heat shock protein 8 [KO:K03283]
15482  Hspa1l; heat shock protein 1-like [KO:K03283]
15511  Hspa1b; heat shock protein 1B [KO:K03283]
15512  Hspa2; heat shock protein 2 [KO:K26598]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
15525  Hspa4; heat shock protein 4 [KO:K09489]
15978  Ifng; interferon gamma [KO:K04687]
16149  Cd74; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [KO:K06505]
16641  Klrc1; killer cell lectin-like receptor subfamily C, member 1 [KO:K06541]
16643  Klrd1; killer cell lectin-like receptor, subfamily D, member 1 [KO:K06516]
170767  Rfxap; regulatory factor X-associated protein [KO:K08063]
18044  Nfya; nuclear transcription factor-Y alpha [KO:K08064]
18045  Nfyb; nuclear transcription factor-Y beta [KO:K08065]
18046  Nfyc; nuclear transcription factor-Y gamma [KO:K08066]
19141  Lgmn; legumain [KO:K01369] [EC:3.4.22.34]
19186  Psme1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [KO:K06696]
19188  Psme2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [KO:K06697]
19192  Psme3; proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) [KO:K06698]
193740  Hspa1a; heat shock protein 1A [KO:K03283]
19727  Rfxank; regulatory factor X-associated ankyrin-containing protein [KO:K08062]
21354  Tap1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05653] [EC:7.4.2.14]
21355  Tap2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654] [EC:7.4.2.14]
21356  Tapbp; TAP binding protein [KO:K08058]
21926  Tnf; tumor necrosis factor [KO:K03156]
224753  H2-M10.4; histocompatibility 2, M region locus 10.4 [KO:K06751]
224754  H2-M11; histocompatibility 2, M region locus 11 [KO:K06751]
224756  H2-M1; histocompatibility 2, M region locus 1 [KO:K06751]
224761  H2-M10.5; histocompatibility 2, M region locus 10.5 [KO:K06751]
240095  H2-M5; histocompatibility 2, M region locus 5 [KO:K06751]
245615  Kir3dl2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 [KO:K07980]
245616  Kir3dl1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [KO:K07980]
333715  H2-M10.2; histocompatibility 2, M region locus 10.2 [KO:K06751]
381091  H2-Eb2; histocompatibility 2, class II antigen E beta2 [KO:K06752]
399549  H2-M10.6; histocompatibility 2, M region locus 10.6 [KO:K06751]
53970  Rfx5; regulatory factor X, 5 (influences HLA class II expression) [KO:K08061]
547349  H2-K1; MHC class I family member [KO:K06751]
621823  Psme2b; protease (prosome, macropain) activator subunit 2B [KO:K06697]
630294  H2-T25; histocompatibility-2, T region locus 25 [KO:K06751]
65972  Ifi30; interferon gamma inducible protein 30 [KO:K08059]
667977  H2-T26; histocompatibility 2, T region locus 26 [KO:K06751]
69717  Gm10499; predicted gene 10499 [KO:K06751]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
mmu03050  Proteasome
mmu04650  Natural killer cell mediated cytotoxicity
mmu04660  T cell receptor signaling pathway
KO pathway
ko04612   

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