KEGG   PATHWAY: mna04142
Entry
mna04142                    Pathway                                
Name
Lysosome - Miniopterus natalensis (Natal long-fingered bat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mna04142  Lysosome
mna04142

Other DBs
GO: 0005764
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107523903  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
107523914  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
107523984  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
107524064  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
107524122  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
107524286  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
107524379  GUSB; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
107524819  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
107525006  CLTB; clathrin light chain B [KO:K04645]
107525010  TLDC1; TLD domain-containing protein 1 [KO:K27947]
107525441  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
107525553  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
107526123  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
107526202  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
107526391  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
107526501  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
107526506  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
107526690  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
107526759  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
107527081  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
107527504  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
107527537  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
107527888  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
107528025  CTNS; cystinosin [KO:K12386]
107528272  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
107528358  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
107528401  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
107528844  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
107528935  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
107529150  SUMF1; sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
107529515  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
107529626  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
107529651  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107529700  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
107529806  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
107530067  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
107530134  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
107530309  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
107530711  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
107530900  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
107531194  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
107531222  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
107531602  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
107531624  SLC17A5; sialin isoform X1 [KO:K12301]
107531711  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
107531841  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
107532059  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
107532060  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
107532450  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
107532989  SCARB2; lysosome membrane protein 2 [KO:K12384]
107533168  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107533233  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
107533243  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
107533366  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107533408  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
107533490  NPC2; epididymal secretory protein E1 [KO:K13443]
107533534  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
107533617  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
107534040  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
107534321  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
107534415  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
107534597  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
107534864  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
107534883  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
107534967  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
107535051  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
107535725  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
107535919  NPC1; Niemann-Pick C1 protein isoform X1 [KO:K12385]
107536050  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
107536083  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
107536154  ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642]
107536613  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
107536903  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
107536957  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107537310  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
107537332  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
107537406  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107537802  GM2A; ganglioside GM2 activator isoform X1 [KO:K12383]
107537931  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
107538220  CD63; CD63 antigen [KO:K06497]
107538264  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
107538421  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107539012  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
107539106  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
107539127  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
107539235  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
107539403  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
107539874  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
107539911  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
107540389  LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
107540407  [KO:K12399]
107540477  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
107540509  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
107540645  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
107540710  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
107540924  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
107541022  CLN3; battenin isoform X1 [KO:K12389]
107541088  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
107541541  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
107541549  MAN2B1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
107541957  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
107542898  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
107543082  [KO:K01365] [EC:3.4.22.15]
107543180  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
107543346  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
107543502  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
107543853  GBA; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
107544047  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
107544152  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
107544475  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107544533  CD68; macrosialin [KO:K06501]
107544669  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
107544769  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
107544834  [KO:K01319] [EC:3.4.21.20]
107544837  [KO:K01319] [EC:3.4.21.20]
107544917  CLTA; clathrin light chain A isoform X1 [KO:K04644]
107544923  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107545075  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
107545081  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
107545082  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
107545143  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
107545312  SORT1; sortilin isoform X1 [KO:K12388]
107545356  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
107545395  [KO:K01319] [EC:3.4.21.20]
107545428  WDR7; WD repeat-containing protein 7 [KO:K24738]
107545509  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
107545745  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107545831  PSAP; prosaposin isoform X1 [KO:K12382]
107545847  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
107546389  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
107546390  LAPTM4A; lysosomal-associated transmembrane protein 4A isoform X1 [KO:K12387]
107546505  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mna00511  Other glycan degradation
mna00531  Glycosaminoglycan degradation
mna04130  SNARE interactions in vesicular transport
mna04140  Autophagy - animal
mna04144  Endocytosis
KO pathway
ko04142   

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