KEGG   PATHWAY: mnp03013
Entry
mnp03013                    Pathway                                
Name
Nucleocytoplasmic transport - Mustela nigripes (black-footed ferret)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mnp03013  Nucleocytoplasmic transport
mnp03013

Other DBs
GO: 0050658
Organism
Mustela nigripes (black-footed ferret) [GN:mnp]
Gene
131998714  [KO:K14302]
131998871  XPO7; exportin-7 isoform X1 [KO:K18460]
131999149  SNUPN; snurportin-1 [KO:K13151]
131999801  ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
131999835  IPO4; importin-4 [KO:K20221]
131999903  PNN; pinin [KO:K13114]
132000736  IPO13; importin-13 isoform X1 [KO:K25202]
132000893  MAGOH; protein mago nashi homolog [KO:K12877]
132000895  NDC1; nucleoporin NDC1 [KO:K14315]
132001416  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
132001469  [KO:K03231]
132001799  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
132001983  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
132002535  [KO:K14324]
132002618  KPNA3; importin subunit alpha-4 [KO:K23583]
132002628  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
132002772  [KO:K12160]
132002842  SAP18; histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
132002908  IPO5; importin-5 [KO:K20222]
132002947  NUP58; nucleoporin p58/p45 [KO:K14307]
132003002  XPO4; exportin-4 [KO:K25203]
132003149  ALYREF; THO complex subunit 4 [KO:K12881]
132003324  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
132003434  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
132003782  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
132003926  CASC3; protein CASC3 [KO:K14323]
132004216  KPNB1; importin subunit beta-1 [KO:K14293]
132004244  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
132004432  [KO:K13171]
132004881  [KO:K18655] [EC:5.6.2.7]
132005730  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
132006102  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
132006124  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
132006161  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
132006608  [KO:K15042]
132006695  [KO:K14284]
132006752  [KO:K14284]
132006898  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
132007049  [KO:K14284]
132007265  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
132007369  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
132007456  [KO:K12160]
132007596  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
132007756  NXT2; NTF2-related export protein 2 [KO:K14285]
132007833  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
132008267  [KO:K14303]
132008513  [KO:K14303]
132011026  TNPO2; transportin-2 isoform X1 [KO:K18727]
132011200  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
132011471  THOC7; THO complex subunit 7 homolog [KO:K13176]
132011556  SEC13; protein SEC13 homolog [KO:K14004]
132011597  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
132011851  KPNA1; importin subunit alpha-5 [KO:K23940]
132011908  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
132011965  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
132012075  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
132012079  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
132012470  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
132013241  [KO:K03345] [EC:3.4.22.68]
132013460  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
132013890  NUP35; nucleoporin NUP35 [KO:K14313]
132015271  [KO:K15043]
132015316  [KO:K12160]
132015673  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
132015719  TNPO3; transportin-3 isoform X1 [KO:K15436]
132015883  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
132016137  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
132016373  [KO:K12160]
132017162  POM121L2; POM121-like protein 2 [KO:K14316]
132017289  [KO:K14324]
132017626  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
132017778  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
132017928  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
132018022  XPO5; exportin-5 isoform X1 [KO:K14289]
132018115  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
132018235  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
132018754  [KO:K03231]
132018766  [KO:K15043]
132019128  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
132019186  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
132019321  NUP37; nucleoporin Nup37 [KO:K14302]
132019437  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
132019463  XPOT; exportin-T [KO:K14288]
132019489  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
132019537  IPO8; importin-8 isoform X1 [KO:K18755]
132019727  AAAS; aladin isoform X1 [KO:K14320]
132019783  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
132019855  NXF1; nuclear RNA export factor 1 [KO:K14284]
132020183  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
132020390  [KO:K12877]
132020793  [KO:K14324]
132021522  XPO1; exportin-1 [KO:K14290]
132021656  [KO:K12172] [EC:2.3.2.-]
132022005  CSE1L; exportin-2 [KO:K18423]
132022048  RAE1; mRNA export factor RAE1 [KO:K14298]
132022110  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
132022642  NXT1; NTF2-related export protein 1 [KO:K14285]
132023063  RAN; GTP-binding nuclear protein Ran [KO:K07936]
132023213  IPO7; importin-7 isoform X1 [KO:K20223]
132023309  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
132023359  [KO:K03231]
132023453  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
132023516  THOC1; THO complex subunit 1 [KO:K12878]
132023660  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
132024320  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
132024350  NUP188; nucleoporin NUP188 [KO:K14311]
132024367  GLE1; mRNA export factor GLE1 [KO:K18723]
132024580  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
132024961  [KO:K18460]
132025393  AHCTF1; protein ELYS isoform X1 [KO:K25129]
132025467  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
132025601  IPO9; importin-9 isoform X1 [KO:K20224]
132025946  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
132026614  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
132026789  XPO6; exportin-6 isoform X1 [KO:K25204]
132026984  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
132027010  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
132027061  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
132027273  KPNA7; importin subunit alpha-8 [KO:K15043]
132027723  [KO:K15043]
132027821  [KO:K14284]
132027844  THOC3; THO complex subunit 3 [KO:K12880]
132027962  [KO:K12160]
132028254  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
132028415  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
132028674  IPO11; importin-11 isoform X1 [KO:K25201]
132028717  TNPO1; transportin-1 isoform X1 [KO:K18752]
132028859  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mnp03015  mRNA surveillance pathway
KO pathway
ko03013   

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