KEGG   PATHWAY: nle03040
Entry
nle03040                    Pathway                                
Name
Spliceosome - Nomascus leucogenys (northern white-cheeked gibbon)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
nle03040  Spliceosome
nle03040

Other DBs
GO: 0005681
Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
115833899  U1 spliceosomal RNA [KO:K14276]
115838167  U1 spliceosomal RNA [KO:K14276]
115837832  U1 spliceosomal RNA [KO:K14276]
115835005  U1 spliceosomal RNA [KO:K14276]
115838168  U1 spliceosomal RNA [KO:K14276]
115833486  U1 spliceosomal RNA [KO:K14276]
115833901  U1 spliceosomal RNA [KO:K14276]
115834604  U1 spliceosomal RNA [KO:K14276]
115832045  U1 spliceosomal RNA [KO:K14276]
115835345  U1 spliceosomal RNA [KO:K14276]
115832193  U1 spliceosomal RNA [KO:K14276]
115836542  U1 spliceosomal RNA [KO:K14276]
115837844  U1 spliceosomal RNA [KO:K14276]
115834603  U1 spliceosomal RNA [KO:K14276]
115837839  U1 spliceosomal RNA [KO:K14276]
115836540  U1 spliceosomal RNA [KO:K14276]
115832214  U1 spliceosomal RNA [KO:K14276]
115834602  U1 spliceosomal RNA [KO:K14276]
115833591  U1 spliceosomal RNA [KO:K14276]
115835344  U1 spliceosomal RNA [KO:K14276]
115835346  U1 spliceosomal RNA [KO:K14276]
115835347  U1 spliceosomal RNA [KO:K14276]
115835685  U1 spliceosomal RNA [KO:K14276]
115834606  U2 spliceosomal RNA [KO:K14277]
115836110  U2 spliceosomal RNA [KO:K14277]
115831658  U2 spliceosomal RNA [KO:K14277]
115835011  U2 spliceosomal RNA [KO:K14277]
115831397  U2 spliceosomal RNA [KO:K14277]
115835718  U2 spliceosomal RNA [KO:K14277]
115836200  U2 spliceosomal RNA [KO:K14277]
115837176  U2 spliceosomal RNA [KO:K14277]
115838175  U2 spliceosomal RNA [KO:K14277]
115832052  U2 spliceosomal RNA [KO:K14277]
115837854  U2 spliceosomal RNA [KO:K14277]
115836098  U2 spliceosomal RNA [KO:K14277]
115835348  U2 spliceosomal RNA [KO:K14277]
115836202  U4 spliceosomal RNA [KO:K14278]
115837186  U4 spliceosomal RNA [KO:K14278]
115837185  U4 spliceosomal RNA [KO:K14278]
115836558  U4 spliceosomal RNA [KO:K14278]
115837458  U4 spliceosomal RNA [KO:K14278]
115836559  U4 spliceosomal RNA [KO:K14278]
115832945  U4 spliceosomal RNA [KO:K14278]
115832074  U4 spliceosomal RNA [KO:K14278]
115838515  U4 spliceosomal RNA [KO:K14278]
115834627  U4 spliceosomal RNA [KO:K14278]
115834846  U4 spliceosomal RNA [KO:K14278]
115835230  U4 spliceosomal RNA [KO:K14278]
115833178  U4 spliceosomal RNA [KO:K14278]
115835030  U4 spliceosomal RNA [KO:K14278]
115830593  U4 spliceosomal RNA [KO:K14278]
115838517  U4 spliceosomal RNA [KO:K14278]
115833513  U4 spliceosomal RNA [KO:K14278]
115832733  U4 spliceosomal RNA [KO:K14278]
115837459  U4 spliceosomal RNA [KO:K14278]
115837187  U4 spliceosomal RNA [KO:K14278]
115835805  U4 spliceosomal RNA [KO:K14278]
115831675  U4 spliceosomal RNA [KO:K14278]
115837682  U4 spliceosomal RNA [KO:K14278]
115838183  U4 spliceosomal RNA [KO:K14278]
115833119  U4 spliceosomal RNA [KO:K14278]
115836562  U5 spliceosomal RNA [KO:K14279]
115835808  U5 spliceosomal RNA [KO:K14279]
115837191  U5 spliceosomal RNA [KO:K14279]
115833067  U5 spliceosomal RNA [KO:K14279]
115837688  U5 spliceosomal RNA [KO:K14279]
115837687  U5 spliceosomal RNA [KO:K14279]
115833518  U5 spliceosomal RNA [KO:K14279]
115836235  U6 spliceosomal RNA [KO:K14280]
115836564  U6 spliceosomal RNA [KO:K14280]
115831100  U6 spliceosomal RNA [KO:K14280]
115834854  U6 spliceosomal RNA [KO:K14280]
115831098  U6 spliceosomal RNA [KO:K14280]
115834496  U6 spliceosomal RNA [KO:K14280]
115837192  U6 spliceosomal RNA [KO:K14280]
115833382  U6 spliceosomal RNA [KO:K14280]
115833625  U6 spliceosomal RNA [KO:K14280]
115834487  U6 spliceosomal RNA [KO:K14280]
115835246  U6 spliceosomal RNA [KO:K14280]
115837696  U6 spliceosomal RNA [KO:K14280]
115832737  U6 spliceosomal RNA [KO:K14280]
115832077  U6 spliceosomal RNA [KO:K14280]
115833079  U6 spliceosomal RNA [KO:K14280]
115834001  U6 spliceosomal RNA [KO:K14280]
115836862  U6 spliceosomal RNA [KO:K14280]
115831787  U6 spliceosomal RNA [KO:K14280]
115836867  U6 spliceosomal RNA [KO:K14280]
115831999  U6 spliceosomal RNA [KO:K14280]
115835262  U6 spliceosomal RNA [KO:K14280]
115836788  U6 spliceosomal RNA [KO:K14280]
115836796  U6 spliceosomal RNA [KO:K14280]
115836027  U6 spliceosomal RNA [KO:K14280]
115836227  U6 spliceosomal RNA [KO:K14280]
115833583  U6 spliceosomal RNA [KO:K14280]
115838518  U6 spliceosomal RNA [KO:K14280]
115833615  U6 spliceosomal RNA [KO:K14280]
115836023  U6 spliceosomal RNA [KO:K14280]
115836237  U6 spliceosomal RNA [KO:K14280]
115833385  U6 spliceosomal RNA [KO:K14280]
115832237  U6 spliceosomal RNA [KO:K14280]
115836473  U6 spliceosomal RNA [KO:K14280]
115835814  U6 spliceosomal RNA [KO:K14280]
115833188  U6 spliceosomal RNA [KO:K14280]
115835235  U6 spliceosomal RNA [KO:K14280]
115831407  U6 spliceosomal RNA [KO:K14280]
115838519  U6 spliceosomal RNA [KO:K14280]
115832234  U6 spliceosomal RNA [KO:K14280]
115836222  U6 spliceosomal RNA [KO:K14280]
115833522  U6 spliceosomal RNA [KO:K14280]
115838522  U6 spliceosomal RNA [KO:K14280]
115832079  U6 spliceosomal RNA [KO:K14280]
115830772  U6 spliceosomal RNA [KO:K14280]
115835248  U6 spliceosomal RNA [KO:K14280]
115835239  U6 spliceosomal RNA [KO:K14280]
115831588  U6 spliceosomal RNA [KO:K14280]
115836567  U6 spliceosomal RNA [KO:K14280]
115831772  U6 spliceosomal RNA [KO:K14280]
115831756  U6 spliceosomal RNA [KO:K14280]
115831118  U6 spliceosomal RNA [KO:K14280]
115837464  U6 spliceosomal RNA [KO:K14280]
115830767  U6 spliceosomal RNA [KO:K14280]
115831679  U6 spliceosomal RNA [KO:K14280]
115834858  U6 spliceosomal RNA [KO:K14280]
115837694  U6 spliceosomal RNA [KO:K14280]
115834490  U6 spliceosomal RNA [KO:K14280]
115830611  U6 spliceosomal RNA [KO:K14280]
115832238  U6 spliceosomal RNA [KO:K14280]
115837200  U6 spliceosomal RNA [KO:K14280]
115833375  U6 spliceosomal RNA [KO:K14280]
115832742  U6 spliceosomal RNA [KO:K14280]
115833373  U6 spliceosomal RNA [KO:K14280]
115830770  U6 spliceosomal RNA [KO:K14280]
115832555  U6 spliceosomal RNA [KO:K14280]
115834878  U6 spliceosomal RNA [KO:K14280]
115831982  U6 spliceosomal RNA [KO:K14280]
115831750  U6 spliceosomal RNA [KO:K14280]
100602289  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X2 [KO:K12811] [EC:5.6.2.7]
100583305  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
100596672  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
100579235  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
100579189  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
100594538  PRPF18; pre-mRNA-splicing factor 18 isoform X2 [KO:K12817]
100591544  DHX8; ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
100582616  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
100589799  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
100591564  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X4 [KO:K11086]
100607793  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
100606188  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
100598885  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
100592962  small nuclear ribonucleoprotein E [KO:K11097]
105740278  small nuclear ribonucleoprotein E-like [KO:K11097]
115835167  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
100594777  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
100606424  SNRPG; small nuclear ribonucleoprotein G isoform X2 [KO:K11099]
115834773  small nuclear ribonucleoprotein G-like [KO:K11099]
100595176  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
100586169  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
100582567  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
100598388  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X2 [KO:K12821]
100582970  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
100585594  RBM25; RNA-binding protein 25 [KO:K12822]
100603290  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100583166  TCERG1; transcription elongation regulator 1 isoform X4 [KO:K12824]
100594007  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
100599457  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
100605563  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
100604508  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
105739075  uncharacterized protein LOC105739075 [KO:K12826]
115834173  LOW QUALITY PROTEIN: splicing factor 3A subunit 2-like [KO:K12826]
100601434  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
100604147  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
100596229  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
100606766  splicing factor 3B subunit 3 [KO:K12830]
105740613  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
100589210  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
100584402  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
100591091  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
100586736  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
100598318  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
100579477  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
100591378  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
100601715  PUF60; poly(U)-binding-splicing factor PUF60 isoform X9 [KO:K12838]
100582421  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
100582439  RBM17; splicing factor 45 [KO:K12840]
100587561  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
100601047  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
100602814  retinitis pigmentosa 9 protein [KO:K19604]
100594047  LSM2; U6 snRNA-associated Sm-like protein LSm2 isoform X1 [KO:K12621]
100589617  LSM3; U6 snRNA-associated Sm-like protein LSm3 isoform X4 [KO:K12622]
100600323  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
100579279  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
100580341  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
100580561  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
100602163  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
100595577  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
100589951  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X2 [KO:K12662]
100592139  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
100604738  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 isoform X1 [KO:K12844]
100600266  NHP2-like protein 1 isoform X2 [KO:K12845]
115830397  NHP2-like protein 1 isoform X1 [KO:K12845]
100604202  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
100580518  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X2 [KO:K12847]
100593383  SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
100583726  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
100606118  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
100602531  PRPF38B; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
100606135  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852]
100600464  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
100594338  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
100607577  PRPF8; pre-mRNA-processing-splicing factor 8 isoform X1 [KO:K12856]
100583223  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
100588301  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
100600460  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
100593501  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
100599365  CDC5L; cell division cycle 5-like protein [KO:K12860]
100589964  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
100606384  PLRG1; pleiotropic regulator 1 [KO:K12862]
100597122  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
100589084  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
100579396  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100579550  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100594395  heat shock 70 kDa protein 1 [KO:K03283]
115832445  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
100605907  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100600773  PQBP1; polyglutamine-binding protein 1 isoform X4 [KO:K12865]
100596641  WBP11; WW domain-binding protein 11 [KO:K12866]
100602374  SNW1; SNW domain-containing protein 1 isoform X2 [KO:K06063]
100583813  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
100592121  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
100590421  CRNKL1; crooked neck-like protein 1 [KO:K12869]
100580907  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
100600107  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
100605590  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
100584440  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
100605223  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
100590149  BUD31; protein BUD31 homolog [KO:K12873]
100604150  AQR; RNA helicase aquarius [KO:K12874]
100594211  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
100584471  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100591768  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
100579937  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
100592835  protein mago nashi homolog [KO:K12877]
100595049  MAGOH; protein mago nashi homolog [KO:K12877]
100580031  THOC1; THO complex subunit 1 [KO:K12878]
100600463  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
100585766  THOC3; THO complex subunit 3 [KO:K12880]
100598331  ALYREF; THO complex subunit 4 [KO:K12881]
100588470  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
100601582  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
115833241  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
101177069  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100591795  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
100579632  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
100597910  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100579891  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
115831150  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101176468  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
115835046  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101179278  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
100606103  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100588244  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X3 [KO:K12884]
100595872  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
100601168  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
100590163  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
100607255  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
100605084  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
100604024  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
100587315  serine/arginine-rich splicing factor 8 isoform X1 [KO:K12891]
105737598  SRSF8; serine/arginine-rich splicing factor 8 [KO:K12891]
100602260  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
100598519  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
100602397  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
100597914  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
100587770  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
100587720  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
100579571  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
101176300  serine/arginine-rich splicing factor 9-like [KO:K21123]
100591812  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
100603557  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
100581587  SRSF10; serine/arginine-rich splicing factor 10 isoform X4 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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