mGluR5-Ca2+ -apoptotic pathway

Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway

VGCC-Ca2+ -apoptotic pathway

Mutation-caused aberrant Htt to VGCC-Ca2+ -apoptotic pathway

Transport of calcium

Mutation-caused aberrant Htt to transport of calcium

26S proteasome-mediated protein degradation

Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation

Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1

Mutation-caused aberrant Htt to autophagy-vesicle nucleation

Extrinsic apoptotic pathway

Mutation-caused aberrant Htt to extrinsic apoptotic pathway

TNF-JNK signaling pathway

Mutation-caused aberrant Htt to TNF-JNK signaling pathway

Electron transfer in Complex II

Mutation-caused aberrant Htt to electron transfer in Complex II

Electron transfer in Complex III

Mutation-caused aberrant Htt to electron transfer in Complex III

Retrograde axonal transport

Mutation-caused aberrant Htt to retrograde axonal transport

Anterograde axonal transport

Mutation-caused aberrant Htt to anterograde axonal transport

Mutation-caused aberrant Htt to REST-mediated transcriptional repression

Mutation-caused aberrant Htt to CREB-mediated transcription

Mutation-caused aberrant Htt to p53-mediated transcription