KEGG   PATHWAY: ola00590
Entry
ola00590                    Pathway                                
Name
Arachidonic acid metabolism - Oryzias latipes (Japanese medaka)
Class
Metabolism; Lipid metabolism
Pathway map
ola00590  Arachidonic acid metabolism
ola00590

Other DBs
GO: 0019369
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
101175621  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
101173712  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101170929  phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101155667  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101156220  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101162698  proca1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
101162393  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
105355175  group 3 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
101172400  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101156151  pla2g4c; cytosolic phospholipase A2 gamma isoform X2 [KO:K16342] [EC:3.1.1.4]
101160628  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101164444  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105357244  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101157546  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101173355  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101169090  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101168683  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101161174  prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
101173634  prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
100359365  ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
101162769  ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101163397  ptges2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
101156737  ptges3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
101161606  prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
100125494  cbr1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101173382  fam213b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
101160831  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
111946292  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
101169963  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
101171390  hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
101158441  tbxas1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
101165663  lipocalin [KO:K01830] [EC:5.3.99.2]
101166755  lipocalin [KO:K01830] [EC:5.3.99.2]
101170919  ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
101165738  arachidonate 12-lipoxygenase, 12R-type-like [KO:K00461] [EC:1.13.11.34]
101160835  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101172215  lta4h; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
101159978  zadh2; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
101173668  ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
101158478  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101171947  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
111946321  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101165938  ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
100820715  ggt1b; gamma-glutamyl transferase 1b [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100820728  ggtl1b; gamma-glutamyl transferase-like 1b [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105357674  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100820716  ggtl1a; gamma-glutamyl transferase-like 1a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100820714  ggt1a; gamma-glutamyl transferase 1a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101161114  glutathione hydrolase 5 proenzyme isoform X2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101160762  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like [KO:K05361] [EC:1.11.1.12]
111946273  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like [KO:K05361] [EC:1.11.1.12]
101160642  phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform X3 [KO:K05361] [EC:1.11.1.12]
100302452  cyp2p3; cytochrome P450 2P3 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105353996  cytochrome P450 2J1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101167098  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
101174953  arachidonate 5-lipoxygenase [KO:K00458] [EC:1.13.11.31]
101168429  arachidonate 8S-lipoxygenase-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101165367  hydroperoxide isomerase ALOXE3-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101165945  arachidonate 15-lipoxygenase B-like isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101161284  arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101162054  arachidonate 8S-lipoxygenase [KO:K08022] [EC:1.13.11.33 1.13.11.-]
111947934  arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101165239  arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101159319  arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101163757  arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101174158  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101162978  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
110014609  arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101172589  arachidonate 8S-lipoxygenase [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101157276  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
ola00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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