KEGG   PATHWAY: omc00590
Entry
omc00590                    Pathway                                
Name
Arachidonic acid metabolism - Onychostoma macrolepis
Class
Metabolism; Lipid metabolism
Pathway map
omc00590  Arachidonic acid metabolism
omc00590

Other DBs
GO: 0019369
Organism
Onychostoma macrolepis [GN:omc]
Gene
131548388  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
131536289  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
131551690  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
131540204  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
131554278  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
131540717  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
131540815  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
131540817  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
131540818  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
131523266  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
131541104  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131541107  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131541377  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131524705  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
131525652  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
131527222  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
131522768  pla2g4f.2; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
131540116  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131540135  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131540148  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
131529897  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
131523202  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
131527230  si:dkey-177p2.18; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
131525185  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
131537678  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
131553184  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
131553442  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
131540425  ptgs1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
131524712  ptgs2a; prostaglandin G/H synthase 2a [KO:K11987] [EC:1.14.99.1]
131527224  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
131541693  ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
131545744  ptgesl; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
131532654  ptges3a; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
131532706  ptges3b; prostaglandin E synthase 3b [KO:K15730] [EC:5.3.99.3]
131528706  cbr1l; carbonyl reductase 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
131545739  cbr1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
131548906  prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
131540789  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
131529399  zgc:56585; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
131539656  hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
131524225  tbxas1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
131523592  lipocalin-like [KO:K01830] [EC:5.3.99.2]
131541486  zgc:153704; lipocalin-like [KO:K01830] [EC:5.3.99.2]
131533472  lipocalin-like [KO:K01830] [EC:5.3.99.2]
131542923  ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
131552688  alox5a; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
131538449  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
131538622  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
131538839  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
131539153  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
131539371  polyunsaturated fatty acid 5-lipoxygenase-like isoform X1 [KO:K00461] [EC:1.13.11.34]
131539557  lta4h; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
131523239  ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
131544309  ptgr1.2; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
131544310  ptgr1.1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
131553486  ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
131547574  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131547622  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131548619  ggt1b; glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131548697  ggt5b; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131530650  gpx4a; glutathione peroxidase 4a isoform X1 [KO:K05361] [EC:1.11.1.12]
131522086  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
131526777  cytochrome P450 2J3-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
131526778  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
131538917  cytochrome P450 2J4-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
131540211  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
131543981  alox12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
131528522  si:dkey-17e16.9; hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
131522670  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
omc00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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