KEGG   PATHWAY: oor00330
Entry
oor00330                    Pathway                                
Name
Arginine and proline metabolism - Orcinus orca (killer whale)
Class
Metabolism; Amino acid metabolism
Pathway map
oor00330  Arginine and proline metabolism
oor00330

Module
oor_M00015  Proline biosynthesis, glutamate => proline [PATH:oor00330]
oor_M00047  Creatine pathway [PATH:oor00330]
oor_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:oor00330]
oor_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:oor00330]
oor_M00970  Proline degradation, proline => glutamate [PATH:oor00330]
oor_M00972  Proline metabolism [PATH:oor00330]
Other DBs
GO: 0006525 0006560
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101269591  CKB; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
101270298  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
101271460  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
101271753  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X4 [KO:K18123] [EC:4.1.3.16]
101271930  AGMAT; agmatinase, mitochondrial isoform X1 [KO:K27001]
101272484  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
101272622  [KO:K01581] [EC:4.1.1.17]
101272725  [KO:K00274] [EC:1.4.3.4]
101272903  SMS; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
101273057  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101273603  ALDH3A2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
101274047  [KO:K00933] [EC:2.7.3.2]
101274717  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
101276776  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X2 [KO:K00286] [EC:1.5.1.2]
101276910  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
101277576  GOT1; aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
101277779  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X4 [KO:K00472] [EC:1.14.11.2]
101278511  [KO:K00802] [EC:2.5.1.22]
101278936  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
101279003  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101279562  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
101279845  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
101279871  PRODH2; hydroxyproline dehydrogenase isoform X2 [KO:K11394] [EC:1.5.5.3]
101280520  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101280638  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101280936  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
101281194  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
101281356  CNDP1; beta-Ala-His dipeptidase isoform X3 [KO:K05604] [EC:3.4.13.20]
101281457  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
101281495  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [KO:K00294] [EC:1.2.1.88]
101281552  PYCR3; pyrroline-5-carboxylate reductase 3 [KO:K00286] [EC:1.5.1.2]
101282165  PRODH; proline dehydrogenase 1, mitochondrial isoform X2 [KO:K00318] [EC:1.5.5.2]
101282514  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
101282652  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
101282884  SMOX; spermine oxidase isoform X1 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
101283575  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X10 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
101283589  SRM; spermidine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
101283598  CKMT1B; creatine kinase U-type, mitochondrial isoform X1 [KO:K00933] [EC:2.7.3.2]
101284956  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
101285110  CARNS1; carnosine synthase 1 isoform X2 [KO:K14755] [EC:6.3.2.11]
101285984  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
101287040  SAT2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
101287221  PYCR2; pyrroline-5-carboxylate reductase 2 isoform X1 [KO:K00286] [EC:1.5.1.2]
101287258  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X3 [KO:K00472] [EC:1.14.11.2]
101287298  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
101287343  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
101287603  OAT; ornithine aminotransferase, mitochondrial [KO:K00819] [EC:2.6.1.13]
101287780  GOT2; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
101288505  L3HYPDH; trans-3-hydroxy-L-proline dehydratase isoform X2 [KO:K18384] [EC:4.2.1.77]
101288817  CKM; creatine kinase M-type [KO:K27382]
101289055  GAMT; guanidinoacetate N-methyltransferase isoform X2 [KO:K00542] [EC:2.1.1.2]
101289964  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
101290165  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
oor00020  Citrate cycle (TCA cycle)
oor00220  Arginine biosynthesis
oor00250  Alanine, aspartate and glutamate metabolism
oor00260  Glycine, serine and threonine metabolism
oor00270  Cysteine and methionine metabolism
oor00310  Lysine degradation
oor00410  beta-Alanine metabolism
oor00470  D-Amino acid metabolism
oor00480  Glutathione metabolism
oor00630  Glyoxylate and dicarboxylate metabolism
oor00650  Butanoate metabolism
oor00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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