KEGG PATHWAY: oor00260

PATHWAY: oor00260

Entry

oor00260                    Pathway

Name

Glycine, serine and threonine metabolism - Orcinus orca (killer whale)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

oor00260

Glycine, serine and threonine metabolism

Module

oor_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:oor00260]

oor_M00047

Creatine pathway [PATH:oor00260]

oor_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:oor00260]

oor_M00555

Betaine biosynthesis, choline => betaine [PATH:oor00260]

oor_M00621

Glycine cleavage system [PATH:oor00260]

oor_M00974

Betaine metabolism, animals, betaine => glycine [PATH:oor00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Orcinus orca (killer whale) [GN:oor]

Gene

101269373

PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

101269445

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

101269619

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

101270164

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101270773

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

101271343

AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]

101271460

DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

101271932

[KO:K02437]

101272078

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

101272484

MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]

101272725

[KO:K00274] [EC:1.4.3.4]

101273976

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

101274638

PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

101274646

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

101275189

SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]

101275910

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

101277500

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

101278105

CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]

101278349

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X2 [KO:K00281] [EC:1.4.4.2]

101278597

SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

101278767

AOC3; LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

101278882

SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

101279003

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

101279093

DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]

101279373

[KO:K00831] [EC:2.6.1.52]

101280139

GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

101281194

GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]

101281381

CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]

101281473

SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]

101281736

DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X2 [KO:K00315] [EC:1.5.8.4]

101282223

BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

101283886

ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X4 [KO:K00643] [EC:2.3.1.37]

101284691

[KO:K15789] [EC:1.1.1.103]

101284785

PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

101286226

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

101286738

[KO:K01837] [EC:5.4.2.4 5.4.2.11]

101287641

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

101288519

AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

101288560

ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

101288592

[KO:K01620] [EC:4.1.2.48]

101289055

GAMT; guanidinoacetate N-methyltransferase isoform X2 [KO:K00542] [EC:2.1.1.2]

101290448

GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]

105748448

[KO:K02437]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721