KEGG   PATHWAY: acyg04141
Entry
acyg04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Anser cygnoides (swan goose)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
acyg04141  Protein processing in endoplasmic reticulum
acyg04141

Other DBs
GO: 0030433 0034976
Organism
Anser cygnoides (swan goose) [GN:acyg]
Gene
106046212  SEC61A2; protein transport protein Sec61 subunit alpha isoform X2 [KO:K10956]
106038064  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
106036024  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
106046414  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
106031982  SEC62; translocation protein SEC62 [KO:K12275]
106032607  SEC63; translocation protein SEC63 homolog [KO:K09540]
106037921  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
106040863  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
136786829  DAD1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
106048632  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
106040606  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
106043315  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
106038568  MAGT1; magnesium transporter protein 1 isoform X1 [KO:K19478]
106035208  TUSC3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
106038614  OSTC; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
106048301  TMEM258; transmembrane protein 258 [KO:K26502]
125180657  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
106035931  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
106044751  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
106034352  SIL1; nucleotide exchange factor SIL1 isoform X2 [KO:K14001]
106039741  HYOU1; hypoxia up-regulated protein 1 [KO:K09486]
106040714  HSPA5; endoplasmic reticulum chaperone BiP isoform X1 [KO:K09490] [EC:3.6.4.10]
106039139  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
106030142  DNAJC1; dnaJ homolog subfamily C member 1 [KO:K09521]
106049342  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
106030053  DNAJC10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
106035887  HSP90B1; endoplasmin [KO:K09487]
125181874  LOW QUALITY PROTEIN: neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
136788729  LOW QUALITY PROTEIN: neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
106032811  CANX; calnexin [KO:K08054]
106048638  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
106029513  CALR; calreticulin [KO:K08057]
106044940  CALR3; calreticulin-3 [KO:K08057]
106049769  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1 [KO:K01230] [EC:3.2.1.113]
106038021  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [KO:K01230] [EC:3.2.1.113]
106032458  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
106037118  MAN1B1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
106042737  LMAN2; vesicular integral-membrane protein VIP36 [KO:K10082]
106044920  LMAN1; protein ERGIC-53 [KO:K10080]
106049898  PREB; guanine nucleotide-exchange factor SEC12 isoform X1 [KO:K14003]
106030652  SAR1A; small COPII coat GTPase SAR1A [KO:K07953] [EC:3.6.5.-]
106032774  SAR1B; small COPII coat GTPase SAR1B [KO:K07953] [EC:3.6.5.-]
106036773  SEC13; protein SEC13 homolog [KO:K14004]
106049816  SEC31B; protein transport protein Sec31B isoform X1 [KO:K14005]
106041893  SEC31A; protein transport protein Sec31A isoform X1 [KO:K14005]
106038833  SEC23A; protein transport protein Sec23A [KO:K14006]
106044746  SEC23B; protein transport protein Sec23B [KO:K14006]
106038610  protein transport protein Sec24D [KO:K14007]
106038661  SEC24B; protein transport protein Sec24B isoform X3 [KO:K14007]
106032775  SEC24A; protein transport protein Sec24A [KO:K14007]
106033211  SEC24C; protein transport protein Sec24C isoform X1 [KO:K14007]
106049340  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
106040318  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
106036703  EDEM1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
106047756  EDEM2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
106034049  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
106046756  P4HB; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
106048731  PDIA4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
106030814  PDIA6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
106031402  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
106034852  TXNDC5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
106044015  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
106048088  ERO1B; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
106042259  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
106034853  SSR1; translocon-associated protein subunit alpha isoform X2 [KO:K13249]
106049276  SSR2; translocon-associated protein subunit beta [KO:K13250]
106043532  SSR3; translocon-associated protein subunit gamma [KO:K13251]
136787432  BCAP31; LOW QUALITY PROTEIN: B-cell receptor-associated protein 31 [KO:K14009]
106030605  TRAM1; translocating chain-associated membrane protein 1 [KO:K14010]
106041315  translocating chain-associated membrane protein 1-like 1 isoform X1 [KO:K14010]
106038482  DERL1; derlin-1 [KO:K11519]
106041413  DERL2; derlin-2 [KO:K13989]
106031293  DERL3; derlin-3 isoform X1 [KO:K13989]
106039330  UBXN4; UBX domain-containing protein 4 isoform X1 [KO:K24348]
106044498  UBXN2A; UBX domain-containing protein 2A [KO:K24349]
106044987  UBXN6; UBX domain-containing protein 6 isoform X1 [KO:K14011]
106049372  NSFL1C; NSFL1 cofactor p47 [KO:K14012]
106033842  SVIP; small VCP/p97-interacting protein isoform X1 [KO:K14014]
106048536  transitional endoplasmic reticulum ATPase [KO:K13525]
125180969  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
106049410  NPLOC4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
106031252  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1 [KO:K14016]
106039820  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
106040235  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
136788154  LOW QUALITY PROTEIN: dnaJ homolog subfamily A member 1-like [KO:K09502]
106039618  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
125181512  DNAJB1; LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1 [KO:K09507]
106029857  DNAJB2; dnaJ homolog subfamily B member 2 isoform X3 [KO:K09508]
106031297  DNAJB12; dnaJ homolog subfamily B member 12 [KO:K09518]
106030670  DNAJC5B; dnaJ homolog subfamily C member 5B [KO:K09525]
106040812  DNAJC5; dnaJ homolog subfamily C member 5 [KO:K09525]
125181286  DNAJC5G; dnaJ homolog subfamily C member 5G [KO:K09525]
106029748  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
106046988  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
106042435  HSPA4L; heat shock 70 kDa protein 4L [KO:K09485]
106041157  HSPH1; heat shock protein 105 kDa isoform X1 [KO:K09485]
106045014  BAG1; BAG family molecular chaperone regulator 1 isoform X1 [KO:K09555]
106030413  BAG2; BAG family molecular chaperone regulator 2 [KO:K09556]
106036148  CRYAA; alpha-crystallin A chain [KO:K09541]
106039817  CRYAB; alpha-crystallin B chain [KO:K09542]
106041323  YOD1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
106043726  PLAA; phospholipase A-2-activating protein [KO:K14018]
106040437  RAD23B; UV excision repair protein RAD23 homolog B isoform X3 [KO:K10839]
136788283  RAD23A; UV excision repair protein RAD23 homolog A [KO:K10839]
106048972  UBQLN4; ubiquilin-4 [KO:K04523]
106045368  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
125181577  ubiquilin-1-like isoform X1 [KO:K04523]
136789441  ubiquilin-1-like isoform X1 [KO:K04523]
106030294  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X3 [KO:K01456] [EC:3.5.1.52]
106036577  ATXN3; ataxin-3 isoform X2 [KO:K11863] [EC:3.4.22.-]
106044292  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
106033893  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
106031680  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106030027  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
106035925  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106049589  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
106039908  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
106041594  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
106035101  WFS1; wolframin [KO:K14020]
106043118  MBTPS1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
106037836  MBTPS2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
106043879  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
106046018  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106034606  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
106037085  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106032515  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125181848  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
106041872  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
106047189  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106032805  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106049805  LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
106048204  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
136789296  calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
106031621  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
106036559  MARCHF6; E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
106035404  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
106044320  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
106041415  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
106039252  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
106029455  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
136788858  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
106031340  RNF185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
106036505  SELENOS; selenoprotein S [KO:K14025]
106044545  SEL1L; protein sel-1 homolog 1 isoform X1 [KO:K14026]
106033143  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
106043119  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
106033344  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
106030482  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X2 [KO:K06689] [EC:2.3.2.23]
106045338  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X2 [KO:K06689] [EC:2.3.2.23]
106042740  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
106039539  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
106035919  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
106048734  CUL1; cullin-1 [KO:K03347]
106032826  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
106040233  FBXO2; F-box only protein 2 [KO:K10099]
106040232  FBXO44; F-box only protein 44 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
acyg00510  N-Glycan biosynthesis
acyg03050  Proteasome
acyg03060  Protein export
acyg04210  Apoptosis
KO pathway
ko04141   
LinkDB

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