KEGG   PATHWAY: afz04727
Entry
afz04727                    Pathway                                
Name
GABAergic synapse - Antechinus flavipes (yellow-footed antechinus)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
afz04727  GABAergic synapse
afz04727

Other DBs
GO: 0051932
Organism
Antechinus flavipes (yellow-footed antechinus) [GN:afz]
Gene
127564916  sodium-coupled neutral amino acid symporter 1-like [KO:K14990]
127539382  sodium-coupled neutral amino acid symporter 2 [KO:K14207]
127564576  glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
127554460  glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
127564222  glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
127546359  LOW QUALITY PROTEIN: glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
127554560  glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
127550406  vesicular inhibitory amino acid transporter [KO:K15015]
127539407  4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
127542555  gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
127550162  gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
127550164  gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
127539734  gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
127539810  gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
127553719  gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
127550161  gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
127553718  gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
127540832  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
127550165  gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
127553720  gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
127540457  gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
127555990  gamma-aminobutyric acid receptor subunit delta [KO:K05184]
127542673  gamma-aminobutyric acid receptor subunit gamma-4-like [KO:K05185]
127543268  gamma-aminobutyric acid receptor subunit theta [KO:K05192]
127550195  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
127548938  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
127563015  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127543087  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127544835  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127550415  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127560569  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127541963  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127556522  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
127563934  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
127543884  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
127547705  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
127560908  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
127560379  vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
127557039  trafficking kinesin-binding protein 2 [KO:K15374]
127554429  inactive phospholipase C-like protein 1 [KO:K15375]
127549636  gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
127550775  solute carrier family 12 member 5 [KO:K23967]
127553586  gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
127561990  gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
127561991  gamma-aminobutyric acid receptor subunit rho-2 isoform X1 [KO:K05190]
127544819  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
127549060  voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
127564847  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
127550201  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
127543177  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
127562742  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
127562690  gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
127561011  gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
127538251  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
127559382  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
127554531  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
127550729  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
127555995  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127560972  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
127539236  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
127552896  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
127551163  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
127539955  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
127559635  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
127563022  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
127545135  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
127556271  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
127537835  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
127549287  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
127563175  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1 [KO:K04347]
127544789  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
127543277  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
127546557  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
127560296  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
127544134  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
127543614  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127548786  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
127551100  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
127554148  adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
127564773  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
127550695  adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
127544457  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
127542142  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
127553837  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
127552003  sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
127538034  sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
127551996  sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
127564482  sodium- and chloride-dependent betaine transporter [KO:K05045]
127562827  glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
127554556  sodium-coupled neutral amino acid transporter 3 [KO:K13576]
127542591  sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
afz00020  Citrate cycle (TCA cycle)
afz00250  Alanine, aspartate and glutamate metabolism
afz04144  Endocytosis
afz04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

DBGET integrated database retrieval system