KEGG   PATHWAY: apla00260
Entry
apla00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Anas platyrhynchos (mallard)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
apla00260  Glycine, serine and threonine metabolism
apla00260

Module
apla_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:apla00260]
apla_M00047  Creatine pathway [PATH:apla00260]
apla_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:apla00260]
apla_M00555  Betaine biosynthesis, choline => betaine [PATH:apla00260]
apla_M00621  Glycine cleavage system [PATH:apla00260]
apla_M00974  Betaine metabolism, animals, betaine => glycine [PATH:apla00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
113845562  LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
101803642  SHMT2; LOW QUALITY PROTEIN: serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
101802281  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
101789792  AGXT; LOW QUALITY PROTEIN: serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101789544  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
101794217  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
119717297  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101803151  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101800594  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101794860  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
101792685  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
101798307  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
101794341  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
101793120  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
101792808  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
101793000  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
101792066  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
101792268  LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101791583  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
113845106  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101801299  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
119716295  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
101801260  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
119718513  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
101799853  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101796257  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
101803779  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
101802751  CHDH; choline dehydrogenase, mitochondrial isoform X1 [KO:K00108] [EC:1.1.99.1]
101793275  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101802407  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
101802594  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
113845621  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101793569  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
119716560  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
113842961  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
101797717  cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]
101798015  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
101795717  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
101802992  putative threonine dehydratase isoform X1 [KO:K01754] [EC:4.3.1.19]
113845347  SDSL; LOW QUALITY PROTEIN: serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
113841941  D-threo-3-hydroxyaspartate dehydratase-like [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
apla00010  Glycolysis / Gluconeogenesis
apla00020  Citrate cycle (TCA cycle)
apla00230  Purine metabolism
apla00250  Alanine, aspartate and glutamate metabolism
apla00270  Cysteine and methionine metabolism
apla00290  Valine, leucine and isoleucine biosynthesis
apla00330  Arginine and proline metabolism
apla00470  D-Amino acid metabolism
apla00564  Glycerophospholipid metabolism
apla00600  Sphingolipid metabolism
apla00620  Pyruvate metabolism
apla00630  Glyoxylate and dicarboxylate metabolism
apla00640  Propanoate metabolism
apla00860  Porphyrin metabolism
apla00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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