KEGG PATHWAY: balu00270

PATHWAY: balu00270

Entry

balu00270                   Pathway

Name

Cysteine and methionine metabolism - Bacillus albus

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

balu00270

Cysteine and methionine metabolism

Module

balu_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:balu00270]

balu_M00021

Cysteine biosynthesis, serine => cysteine [PATH:balu00270]

balu_M00034

Methionine salvage pathway [PATH:balu00270]

balu_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:balu00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus albus [GN:balu]

Gene

QRY64_02905

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

QRY64_02730

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

QRY64_11260

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

QRY64_16770

pyridoxal-phosphate dependent enzyme [KO:K01738] [EC:2.5.1.47]

QRY64_24755

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

QRY64_24205

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

QRY64_27485

MalY/PatB family protein [KO:K14155] [EC:4.4.1.13]

QRY64_24760

O-acetylserine dependent cystathionine beta-synthase [KO:K17216] [EC:2.5.1.134]

QRY64_01995

mmuM; homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]

QRY64_24190

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

QRY64_24195

bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

QRY64_22920

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]

QRY64_26790

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

QRY64_25815

speH1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

QRY64_28785

speD; adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

QRY64_28780

polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

QRY64_29635

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

QRY64_24765

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

QRY64_14880

S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

QRY64_23080

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

QRY64_04295

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

QRY64_22395

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

QRY64_11430

bifunctional S-methyl-5'-thioadenosine deaminase/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

QRY64_23075

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

QRY64_04300

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

QRY64_23105

methylthioribulose 1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

QRY64_09080

class II aldolase/adducin family protein [KO:K08964] [EC:4.2.1.109]

QRY64_23095

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

QRY64_23100

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

QRY64_23110

cupin domain-containing protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

QRY64_23090

pyridoxal phosphate-dependent aminotransferase [KO:K08969] [EC:2.6.1.117]

QRY64_26195

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

QRY64_26190

GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

QRY64_24770

class I SAM-dependent methyltransferase [KO:K17462] [EC:2.1.1.-]

QRY64_26910

luxS; S-ribosylhomocysteine lyase LuxS [KO:K07173] [EC:4.4.1.21]

QRY64_11185

aspartate kinase [KO:K00928] [EC:2.7.2.4]

QRY64_21630

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

QRY64_14435

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

QRY64_21635

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

QRY64_11965

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

QRY64_15160

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

QRY64_29800

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

QRY64_29805

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

QRY64_26605

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

QRY64_24200

metI; cystathionine gamma-synthase/O-acetylhomoserine thiolyase [KO:K01739] [EC:2.5.1.48]

QRY64_29810

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase [KO:K01740] [EC:2.5.1.49]

QRY64_09405

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

QRY64_11340

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

QRY64_10140

aspB; aspartate transaminase AspB [KO:K00812] [EC:2.6.1.1]

QRY64_10290

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

QRY64_11745

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

QRY64_27290

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

QRY64_13410

aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]

QRY64_26725

amino acid racemase [KO:K25316] [EC:5.1.1.10]

QRY64_18430

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

QRY64_25870

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

QRY64_23625

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

QRY64_23630

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]

QRY64_18695

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

QRY64_18700

serine dehydratase beta chain [KO:K01752] [EC:4.3.1.17]

QRY64_18755

3-phosphoglycerate dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

QRY64_18760

serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors