KEGG PATHWAY: bcb00270

PATHWAY: bcb00270

Entry

bcb00270                    Pathway

Name

Cysteine and methionine metabolism - Bacillus cereus B4264

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bcb00270

Cysteine and methionine metabolism

Module

bcb_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bcb00270]

bcb_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bcb00270]

bcb_M00034

Methionine salvage pathway [PATH:bcb00270]

bcb_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bcb00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus cereus B4264 [GN:bcb]

Gene

BCB4264_A0109

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

BCB4264_A0075

cysK1; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

BCB4264_A1837

cysK2; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

BCB4264_A4491

Cys/Met metabolism PLP-dependent enzyme [KO:K17217] [EC:4.4.1.1 4.4.1.2]

BCB4264_A4371

Cys/Met metabolism PLP-dependent enzyme [KO:K01760] [EC:4.4.1.13]

BCB4264_A5038

aminotransferase, class I/II [KO:K14155] [EC:4.4.1.13]

BCB4264_A4492

cysM; O-acetylserine lyase [KO:K17216] [EC:2.5.1.134]

BCB4264_A4366

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

BCB4264_A4367

homocysteine S-methyltransferase domain protein/methylenetetrahydrofolate reductase family protein [KO:K24042] [EC:2.1.1.13 1.5.1.54]

BCB4264_A4108

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]

BCB4264_A4877

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

BCB4264_A5333

speD2; adenosylmethionine decarboxylase 2 [KO:K01611] [EC:4.1.1.50]

BCB4264_A4691

speD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

BCB4264_A5332

spermine/spermidine synthase family protein [KO:K00797] [EC:2.5.1.16]

BCB4264_A5492

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

BCB4264_A4493

MTA/SAH nucleosidase [KO:K01243] [EC:3.2.2.9]

BCB4264_A2529

phosphorylase family protein [KO:K01243] [EC:3.2.2.9]

BCB4264_A2883

putative MTA/SAH nucleosidase/phosphatase [KO:K01243] [EC:3.2.2.9]

BCB4264_A0393

putative 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCB4264_A4140

putative 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCB4264_A4002

conserved hypothetical protein TIGR00726 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

BCB4264_A1866

chlorohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

BCB4264_A0394

putative translation initiation factor, aIF-2BI family [KO:K08963] [EC:5.3.1.23]

BCB4264_A4139

putative translation initiation factor, aIF-2BI family [KO:K08963] [EC:5.3.1.23]

BCB4264_A4147

class II aldolase/adducin domain protein [KO:K08964] [EC:4.2.1.109]

BCB4264_A1383

methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

BCB4264_A4145

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

BCB4264_A4146

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

BCB4264_A4148

putative 5-methylthio-3-oxo-1-penten-1,2-diol dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

BCB4264_A4143

aminotransferase, class I/II [KO:K08969] [EC:2.6.1.117]

BCB4264_A4763

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

BCB4264_A4762

conserved hypothetical protein [KO:K08968] [EC:1.8.4.14]

BCB4264_A4494

conserved hypothetical protein [KO:K17462] [EC:2.1.1.-]

BCB4264_A4917

luxS; autoinducer-2 production protein LuxS [KO:K07173] [EC:4.4.1.21]

BCB4264_A1821

dapG1; aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

BCB4264_A3898

dapG2; aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

BCB4264_A2392

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCB4264_A3899

asd2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCB4264_A1970

hom1; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCB4264_A2580

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCB4264_A5527

hom2; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCB4264_A5528

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

BCB4264_A4843

putative homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

BCB4264_A4370

metI; cystathionine gamma-synthase/O-acetylhomoserine thiolyase [KO:K01739] [EC:2.5.1.48]

BCB4264_A5529

O-acetylhomoserine/O-acetylserine sulfhydrylase [KO:K01740] [EC:2.5.1.49]

BCB4264_A1850

ilvE2; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

BCB4264_A1449

ilvE1; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

BCB4264_A2559

cysteine dioxygenase type I superfamily [KO:K00456] [EC:1.13.11.20]

BCB4264_A1601

aspB; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

BCB4264_A1634

rhodanese-like domain protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCB4264_A1927

ldh1; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCB4264_A5140

ldh3; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCB4264_A5002

ldh2; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCB4264_A4865

aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]

BCB4264_A2205

aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]

BCB4264_A3235

putative pyridoxal phosphate-dependent deaminase [KO:K05396] [EC:4.4.1.15]

BCB4264_A4702

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

BCB4264_A2482

sdaAB1; L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]

BCB4264_A2483

sdaAA1; L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]

BCB4264_A4247

sdaAA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]

BCB4264_A4248

sdaAB2; L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]

BCB4264_A3260

putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BCB4264_A3261

serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors