KEGG PATHWAY: bcr00270

PATHWAY: bcr00270

Entry

bcr00270                    Pathway

Name

Cysteine and methionine metabolism - Bacillus cereus AH187

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bcr00270

Cysteine and methionine metabolism

Module

bcr_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bcr00270]

bcr_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bcr00270]

bcr_M00034

Methionine salvage pathway [PATH:bcr00270]

bcr_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bcr00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus cereus AH187 [GN:bcr]

Gene

BCAH187_A0119

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

BCAH187_A1954

cysK2; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

BCAH187_A0079

cysK1; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

BCAH187_A4505

Cys/Met metabolism PLP-dependent enzyme [KO:K17217] [EC:4.4.1.1 4.4.1.2]

BCAH187_A4390

Cys/Met metabolism PLP-dependent enzyme [KO:K01760] [EC:4.4.1.13]

BCAH187_A5050

aminotransferase, classes I and II [KO:K14155] [EC:4.4.1.13]

BCAH187_A4506

cysM; O-acetylserine lyase [KO:K17216] [EC:2.5.1.134]

BCAH187_A4385

metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]

BCAH187_A4386

homocysteine S-methyltransferase domain protein/methylenetetrahydrofolate reductase family protein [KO:K24042] [EC:2.1.1.13 1.5.1.54]

BCAH187_A4127

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

BCAH187_A4904

metK; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]

BCAH187_A4706

speD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

BCAH187_A5378

speD2; adenosylmethionine decarboxylase 2 [KO:K01611] [EC:4.1.1.50]

BCAH187_A5377

spermine/spermidine synthase family protein [KO:K00797] [EC:2.5.1.16]

BCAH187_A5548

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

BCAH187_A2915

putative MTA/SAH nucleosidase / phosphatase [KO:K01243] [EC:3.2.2.9]

BCAH187_A2620

phosphorylase family protein [KO:K01243] [EC:3.2.2.9]

BCAH187_A4507

MTA/SAH nucleosidase [KO:K01243] [EC:3.2.2.9]

BCAH187_A0440

putative 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCAH187_A4160

putative 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCAH187_A3953

conserved hypothetical protein TIGR00726 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

BCAH187_A1981

chlorohydrolase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

BCAH187_A0441

putative translation initiation factor, aIF-2BI family [KO:K08963] [EC:5.3.1.23]

BCAH187_A4159

putative translation initiation factor, aIF-2BI family [KO:K08963] [EC:5.3.1.23]

BCAH187_A4169

class II aldolase/adducin domain protein [KO:K08964] [EC:4.2.1.109]

BCAH187_A1486

conserved hypothetical protein [KO:K08964] [EC:4.2.1.109]

BCAH187_A4167

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

BCAH187_A4168

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

BCAH187_A4170

putative 5-methylthio-3-oxo-1-penten-1,2-diol dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

BCAH187_A4164

aminotransferase, classes I and II [KO:K08969] [EC:2.6.1.117]

BCAH187_A4789

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

BCAH187_A4788

conserved hypothetical protein [KO:K08968] [EC:1.8.4.14]

BCAH187_A4508

conserved hypothetical protein [KO:K17462] [EC:2.1.1.-]

BCAH187_A4931

luxS; autoinducer-2 production protein LuxS [KO:K07173] [EC:4.4.1.21]

BCAH187_A1932

dapG1; aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

BCAH187_A3847

dapG2; aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

BCAH187_A2530

asd1; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCAH187_A3848

asd2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCAH187_A2073

hom1; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCAH187_A2664

putative homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCAH187_A5583

hom2; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCAH187_A5584

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

BCAH187_A4867

putative homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

BCAH187_A4389

metI; cystathionine gamma-synthase/O-acetylhomoserine thiolyase [KO:K01739] [EC:2.5.1.48]

BCAH187_A5585

O-acetylhomoserine/O-acetylserine sulfhydrylase [KO:K01740] [EC:2.5.1.49]

BCAH187_A1965

ilvE2; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

BCAH187_A1555

ilvE1; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

BCAH187_C0244

gshAB; glutamate--cysteine ligase/gamma-glutamylcysteine synthetase [KO:K01919] [EC:6.3.2.2]

BCAH187_A1712

aspB; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

BCAH187_A1745

rhodanese-like domain protein [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCAH187_A2028

ldh1; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCAH187_A5012

ldh2; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCAH187_A5142

ldh3; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCAH187_A4889

probable amino-acid racemase [KO:K25316] [EC:5.1.1.10]

BCAH187_A2335

aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]

BCAH187_A3263

putative pyridoxal phosphate-dependent deaminase [KO:K05396] [EC:4.4.1.15]

BCAH187_A4718

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

BCAH187_A4271

sdaAA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit [KO:K01752] [EC:4.3.1.17]

BCAH187_A4272

sdaAB2; L-serine dehydratase, iron-sulfur-dependent, beta subunit [KO:K01752] [EC:4.3.1.17]

BCAH187_A3293

putative D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BCAH187_A3294

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors