KEGG PATHWAY: bcz00270

PATHWAY: bcz00270

Entry

bcz00270                    Pathway

Name

Cysteine and methionine metabolism - Bacillus cereus E33L

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bcz00270

Cysteine and methionine metabolism

Module

bcz_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bcz00270]

bcz_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bcz00270]

bcz_M00034

Methionine salvage pathway [PATH:bcz00270]

bcz_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bcz00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus cereus E33L [GN:bcz]

Gene

BCE33L4978

sat; serine O-acetyltransferase (serine acetyltransferase) [KO:K00640] [EC:2.3.1.30]

BCE33L0084

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

BCE33L0063

cysK; cysteine synthase (cysteine synthase A) (O-acetylserine sulfhydrylase) [KO:K01738] [EC:2.5.1.47]

BCE33L1653

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

BCE33L4116

metC; cystathionine beta-lyase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

BCE33L4008

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

BCE33L4638

patB; aminotransferase, classes I and II [KO:K14155] [EC:4.4.1.13]

BCE33L4117

cysM; cysteine synthase [KO:K17216] [EC:2.5.1.134]

BCE33L4005

metH; 5-methyltetrahydrofolate--homocysteine methyltransferase [KO:K00548] [EC:2.1.1.13]

BCE33L4006

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

BCE33L3760

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

BCE33L4517

metK; S-adenosylmethionine synthetase (methionine adenosyltransferase) [KO:K00789] [EC:2.5.1.6]

BCE33L4323

speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

BCE33L4906

speD; adenosylmethionine decarboxylase (S-adenosylmethionine decarboxylase proenzyme) [KO:K01611] [EC:4.1.1.50]

BCE33L5067

speE; spermidine synthase; putrescine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

BCE33L4905

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

BCE33L2305

pfs; phosphorylase; S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

BCE33L2595

MTA/SAH nucleosidase/phosphatase, N-terminal region [KO:K01243] [EC:3.2.2.9]

BCE33L4118

mtnA; MTA/SAH nucleosidase (5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase) [KO:K01243] [EC:3.2.2.9]

BCE33L2594

phosphatase, C-terminal region [KO:K01243] [EC:3.2.2.9]

BCE33L0318

mtrK; probable 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCE33L3790

mtnK; 5-methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

BCE33L3660

conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

BCE33L1681

chlorohydrolase/deaminase family protein [KO:K12960] [EC:3.5.4.31 3.5.4.28]

BCE33L3789

translation initiation factor, aIF-2BI family [KO:K08963] [EC:5.3.1.23]

BCE33L0319

protein-synthesizing GTPase (translation initiation factor, IF-2B) [KO:K08963] [EC:5.3.1.23]

BCE33L3795

class II aldolase/adducin domain protein [KO:K08964] [EC:4.2.1.109]

BCE33L1223

conserved hypothetical protein; probable aldolase II family [KO:K08964] [EC:4.2.1.109]

BCE33L3793

rbcL; ribulose-bisphosphate carboxylase (ribulose 1,5-bisphosphate carboxylase, large subunit) [KO:K08965] [EC:5.3.2.5]

BCE33L3794

hydrolase, haloacid dehalogenase-like family [KO:K08966] [EC:3.1.3.87]

BCE33L3796

possible 5-methylthio-3-oxo-1-penten-1,2-diol dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

BCE33L3791

aminotransferase, classes I and II [KO:K08969] [EC:2.6.1.117]

BCE33L4398

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

BCE33L4397

conserved hypothetical protein; possible GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

BCE33L4119

conserved hypothetical protein [KO:K17462] [EC:2.1.1.-]

BCE33L4544

luxS; autoinducer-2 production protein [KO:K07173] [EC:4.4.1.21]

BCE33L1623

dapG; aspartokinase [KO:K00928] [EC:2.7.2.4]

BCE33L3559

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

BCE33L2185

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCE33L3560

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

BCE33L5102

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCE33L1782

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCE33L2354

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

BCE33L1784

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

BCE33L5103

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

BCE33L4482

metX; homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

BCE33L4007

metC; cystathionine beta-lyase [KO:K01739] [EC:2.5.1.48]

BCE33L5104

cysD; O-acetylhomoserine sulfhydrylase [KO:K01740] [EC:2.5.1.49]

BCE33L1281

ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

BCE33L1665

ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

BCE33L1427

aspB; aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

BCE33L1455

thiosulfate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

BCE33L1741

ldh; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCE33L4624

ldhP; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCE33L4723

ldhB; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

BCE33L4503

aspartate racemase [KO:K25316] [EC:5.1.1.10]

BCE33L2006

racD; aspartate racemase [KO:K25316] [EC:5.1.1.10]

BCE33L2930

1-aminocyclopropane-1-carboxylate deaminase [KO:K05396] [EC:4.4.1.15]

BCE33L4333

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

BCE33L3893

sdhB; L-serine dehydratase, beta subunit [KO:K01752] [EC:4.3.1.17]

BCE33L3892

sdhA; possible L-serine dehydratase, alpha subunit [KO:K01752] [EC:4.3.1.17]

BCE33L2968

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

BCE33L2969

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors