KEGG   PATHWAY: bgar04145
Entry
bgar04145                   Pathway                                
Name
Phagosome - Bufo gargarizans (Asiatic toad)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
bgar04145  Phagosome
bgar04145

Other DBs
GO: 0045335
Organism
Bufo gargarizans (Asiatic toad) [GN:bgar]
Gene
122926846  vesicle-associated membrane protein 3-like [KO:K13505]
122933109  STX12; syntaxin-12 [KO:K13813]
122921755  STX7; syntaxin-7 [KO:K08488]
122944482  ACTB; actin, cytoplasmic 1 [KO:K05692]
122939974  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122945590  CORO1A; coronin-1A [KO:K13882]
122929463  STX18; syntaxin-18 [KO:K08492]
122943601  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
122945953  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
122946020  major histocompatibility complex class I-related gene protein-like [KO:K06751]
122919486  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
122946248  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
122919680  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
122919682  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
122946540  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
122946541  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
122946019  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
122919317  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
122919385  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
122919390  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
122919480  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
122919611  class II histocompatibility antigen, M alpha chain-like isoform X1 [KO:K06752]
122946171  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
122946223  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
122946740  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
122946786  class II histocompatibility antigen, M alpha chain-like isoform X1 [KO:K06752]
122938335  RAB5A; ras-related protein Rab-5A [KO:K07887]
122930417  RAB5B; ras-related protein Rab-5B [KO:K07888]
122945611  ras-related protein Rab-5B-like [KO:K07888]
122940669  RAB5C; ras-related protein Rab-5C [KO:K07889]
122928043  EEA1; LOW QUALITY PROTEIN: early endosome antigen 1 [KO:K12478]
122924826  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
122933770  TFRC; transferrin receptor protein 1 [KO:K06503]
122942557  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
122930645  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
122943277  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
122927145  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
122935057  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
122938439  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
122921738  V-type proton ATPase subunit D [KO:K02149]
122922096  V-type proton ATPase subunit D-like [KO:K02149]
122926576  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
122929753  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
122943714  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
122946264  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
122946827  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
122928167  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
122941423  V-type proton ATPase subunit e 2 [KO:K02153]
122928467  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
122924509  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
122939835  V-type proton ATPase 116 kDa subunit a3-like isoform X1 [KO:K02154]
122940279  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
122938689  V-type proton ATPase subunit d 2 [KO:K02146]
122920242  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
122938755  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
122945330  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
122924284  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
122927929  V-type proton ATPase subunit S1-like [KO:K03662]
122946249  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
122943453  RAB7A; ras-related protein Rab-7a [KO:K07897]
122933452  RAB7B; ras-related protein Rab-7b [KO:K07898]
122932522  rab-interacting lysosomal protein [KO:K13883]
122921598  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
122930541  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
122944667  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
122938943  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
122938058  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
122920340  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
122944743  tubulin alpha chain [KO:K07374]
122944912  tubulin alpha-1A chain-like [KO:K07374]
122931176  tubulin alpha chain [KO:K07374]
122945792  tubulin alpha-1A chain-like [KO:K07374]
122931904  tubulin alpha-1A chain [KO:K07374]
122932383  TUBA1B; tubulin alpha-1B chain [KO:K07374]
122926575  TUBA8; tubulin alpha-8 chain [KO:K07374]
122932713  tubulin alpha-8 chain [KO:K07374]
122946864  TUBA3E; tubulin alpha-3E chain [KO:K07374]
122927796  tubulin alpha-3 chain [KO:K07374]
122944911  tubulin alpha-1A chain-like [KO:K07374]
122945326  tubulin alpha-1A chain-like [KO:K07374]
122937746  tubulin beta-2 chain [KO:K07375]
122945956  TUBB4B; tubulin beta-4B chain [KO:K07375]
122945968  TUBB; tubulin beta chain [KO:K07375]
122939590  TUBB6; tubulin beta-6 chain [KO:K07375]
122940223  TUBB1; tubulin beta-1 chain [KO:K07375]
122920870  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
122946067  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
122932074  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
122944680  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
122939997  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
122935037  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
122931700  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122931701  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122931839  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122931840  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122932447  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122932595  eosinophil peroxidase-like [KO:K10789] [EC:1.11.2.2]
122940269  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
122922807  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
122927678  zingipain-2-like [KO:K01365] [EC:3.4.22.15]
122927679  zingipain-2-like [KO:K01365] [EC:3.4.22.15]
122927680  zingipain-2-like [KO:K01365] [EC:3.4.22.15]
122923217  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
122923219  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
122943629  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
122938825  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
122938374  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
122919679  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
122919678  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
122944131  calreticulin-like [KO:K08057]
122927281  CALR; calreticulin [KO:K08057]
122922589  calnexin-like [KO:K08054]
122940308  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
122922822  integrin alpha-M-like [KO:K06461]
122944708  ITGB2; integrin beta-2 [KO:K06464]
122922745  complement C3-like [KO:K03990]
122925554  venom factor-like [KO:K03990]
122925555  complement C3-like [KO:K03990]
122925556  venom factor-like [KO:K03990]
122927154  C3; complement C3 [KO:K03990]
122927155  LOW QUALITY PROTEIN: venom factor-like [KO:K03990]
122927156  A.superbus venom factor 1-like [KO:K03990]
122927157  LOW QUALITY PROTEIN: venom factor-like [KO:K03990]
122927158  venom factor-like [KO:K03990]
122927159  venom factor-like [KO:K03990]
122935702  COLEC11; collectin-11 isoform X1 [KO:K10066]
122938932  COLEC12; collectin-12 [KO:K10062]
122923205  mannose-binding protein-like isoform X1 [KO:K03991]
122942382  pulmonary surfactant-associated protein A-like [KO:K10067]
122924241  pulmonary surfactant-associated protein A-like [KO:K10067]
122941183  pulmonary surfactant-associated protein A-like [KO:K10067]
122942325  pulmonary surfactant-associated protein A-like [KO:K10068]
122923203  pulmonary surfactant-associated protein D-like isoform X1 [KO:K10068]
122924242  pulmonary surfactant-associated protein A-like isoform X1 [KO:K10068]
122946190  ITGAV; integrin alpha-V [KO:K06487]
122924792  ITGA2; integrin alpha-2 [KO:K06481]
122931413  ITGA5; integrin alpha-5 [KO:K06484]
122937735  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122940129  ITGB3; integrin beta-3 [KO:K06493]
122942561  ITGB5; integrin beta-5 [KO:K06588]
122922235  THBS1; thrombospondin-1 [KO:K16857]
122936138  THBS4; thrombospondin-4 [KO:K04659]
122929708  cartilage oligomeric matrix protein [KO:K04659]
122933981  THBS2; thrombospondin-2 [KO:K04659]
122942595  TLR2; toll-like receptor 2 [KO:K10159]
122926450  toll-like receptor 2 [KO:K10159]
122941146  toll-like receptor 1 [KO:K10169]
122946542  TLR4; toll-like receptor 4 [KO:K10160]
122942053  C-type mannose receptor 2-like [KO:K06560]
122938192  MRC1; macrophage mannose receptor 1 [KO:K06560]
122938531  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
122945762  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
122940288  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
122927215  hepatic lectin-like [KO:K06563]
122927217  hepatic lectin-like [KO:K06563]
122927218  hepatic lectin-like [KO:K06563]
122940018  killer cell lectin-like receptor subfamily B member 1A [KO:K10074]
122942022  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
122944627  macrophage receptor MARCO-like [KO:K13884]
122924505  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
122925806  CD36; platelet glycoprotein 4 [KO:K06259]
122922517  cytochrome b-245 light chain [KO:K08009]
122931271  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
122944424  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944817  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944818  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122932909  NCF1; neutrophil cytosol factor 1 [KO:K08011]
122943911  NCF2; neutrophil cytosol factor 2 [KO:K08010]
122943292  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
bgar04142  Lysosome
bgar04144  Endocytosis
bgar04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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