KEGG PATHWAY: bpan00270

PATHWAY: bpan00270

Entry

bpan00270                   Pathway

Name

Cysteine and methionine metabolism - Bacillus paranthracis

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

bpan00270

Cysteine and methionine metabolism

Module

bpan_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:bpan00270]

bpan_M00021

Cysteine biosynthesis, serine => cysteine [PATH:bpan00270]

bpan_M00034

Methionine salvage pathway [PATH:bpan00270]

bpan_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:bpan00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus paranthracis [GN:bpan]

Gene

NLJ82_00560

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

NLJ82_09165

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

NLJ82_00385

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

NLJ82_21250

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

NLJ82_20700

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

NLJ82_24105

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

NLJ82_21255

O-acetylserine dependent cystathionine beta-synthase [KO:K17216] [EC:2.5.1.134]

NLJ82_20685

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

NLJ82_20690

bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

NLJ82_19440

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]

NLJ82_23380

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

NLJ82_22410

speH1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

NLJ82_25640

speD; adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

NLJ82_25635

polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

NLJ82_26490

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

NLJ82_12150

S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

NLJ82_13485

HAD hydrolase-like protein [KO:K01243] [EC:3.2.2.9]

NLJ82_13490

5'-methylthioadenosine/adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

NLJ82_21260

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

NLJ82_02090

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

NLJ82_19600

mtnK; S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

NLJ82_18905

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

NLJ82_09305

bifunctional S-methyl-5'-thioadenosine deaminase/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

NLJ82_02095

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

NLJ82_19595

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

NLJ82_06930

class II aldolase/adducin family protein [KO:K08964] [EC:4.2.1.109]

NLJ82_19625

methylthioribulose 1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

NLJ82_19615

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

NLJ82_19620

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

NLJ82_19630

cupin domain-containing protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

NLJ82_19610

pyridoxal phosphate-dependent aminotransferase [KO:K08969] [EC:2.6.1.117]

NLJ82_22820

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

NLJ82_22815

GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

NLJ82_21265

class I SAM-dependent methyltransferase [KO:K17462] [EC:2.1.1.-]

NLJ82_23525

luxS; S-ribosylhomocysteine lyase LuxS [KO:K07173] [EC:4.4.1.21]

NLJ82_09060

aspartate kinase [KO:K00928] [EC:2.7.2.4]

NLJ82_18285

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

NLJ82_11705

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

NLJ82_18290

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

NLJ82_09735

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

NLJ82_12365

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

NLJ82_26660

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

NLJ82_09745

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

NLJ82_26665

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

NLJ82_23205

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

NLJ82_20695

metI; cystathionine gamma-synthase/O-acetylhomoserine thiolyase [KO:K01739] [EC:2.5.1.48]

NLJ82_26670

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase [KO:K01740] [EC:2.5.1.49]

NLJ82_07255

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

NLJ82_09220

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

NLJ82_27665

gshAB; bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB [KO:K01919] [EC:6.3.2.2]

NLJ82_08000

aspB; aspartate transaminase AspB [KO:K00812] [EC:2.6.1.1]

NLJ82_08145

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

NLJ82_09520

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

NLJ82_23920

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

NLJ82_24540

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

NLJ82_10745

aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]

NLJ82_23310

amino acid racemase [KO:K25316] [EC:5.1.1.10]

NLJ82_15235

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

NLJ82_22460

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

NLJ82_20130

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

NLJ82_20135

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]

NLJ82_15385

3-phosphoglycerate dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

NLJ82_15390

serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors