KEGG PATHWAY: btro00270

PATHWAY: btro00270

Entry

btro00270                   Pathway

Name

Cysteine and methionine metabolism - Bacillus tropicus

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

btro00270

Cysteine and methionine metabolism

Module

btro_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:btro00270]

btro_M00021

Cysteine biosynthesis, serine => cysteine [PATH:btro00270]

btro_M00034

Methionine salvage pathway [PATH:btro00270]

btro_M00609

Cysteine biosynthesis, methionine => cysteine [PATH:btro00270]

Other DBs

GO:	0006534 0006555

Organism

Bacillus tropicus [GN:btro]

Gene

FJR70_22190

cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

FJR70_22015

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

FJR70_01630

cysK; cysteine synthase A [KO:K01738] [EC:2.5.1.47]

FJR70_15650

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]

FJR70_15075

metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

FJR70_30750

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

FJR70_18525

pyridoxal phosphate-dependent aminotransferase [KO:K14155] [EC:4.4.1.13]

FJR70_15655

O-acetylserine dependent cystathionine beta-synthase [KO:K17216] [EC:2.5.1.134]

FJR70_15060

metH; methionine synthase [KO:K00548] [EC:2.1.1.13]

FJR70_15065

bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase [KO:K24042] [EC:2.1.1.13 1.5.1.54]

FJR70_13745

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [KO:K00549] [EC:2.1.1.14]

FJR70_17700

metK; methionine adenosyltransferase [KO:K00789] [EC:2.5.1.6]

FJR70_20185

adenosylmethionine decarboxylase [KO:K01611] [EC:4.1.1.50]

FJR70_16645

speH1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

FJR70_20180

polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

FJR70_20995

speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]

FJR70_04805

5'-methylthioadenosine/adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

FJR70_06370

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

FJR70_06460

S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

FJR70_15660

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

FJR70_24030

S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

FJR70_13910

S-methyl-5-thioribose kinase [KO:K00899] [EC:2.7.1.100]

FJR70_12915

pgeF; peptidoglycan editing factor PgeF [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

FJR70_01780

bifunctional S-methyl-5'-thioadenosine deaminase/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

FJR70_24035

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

FJR70_13905

mtnA; S-methyl-5-thioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

FJR70_28925

hypothetical protein [KO:K08964] [EC:4.2.1.109]

FJR70_13935

methylthioribulose 1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

FJR70_13925

mtnW; 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [KO:K08965] [EC:5.3.2.5]

FJR70_13930

mtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

FJR70_13940

cupin domain-containing protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

FJR70_13920

pyridoxal phosphate-dependent aminotransferase [KO:K08969] [EC:2.6.1.117]

FJR70_17050

megL; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

FJR70_17045

GAF domain-containing protein [KO:K08968] [EC:1.8.4.14]

FJR70_07435

DNA cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]

FJR70_15665

class I SAM-dependent methyltransferase [KO:K17462] [EC:2.1.1.-]

FJR70_17875

luxS; S-ribosylhomocysteine lyase LuxS [KO:K07173] [EC:4.4.1.21]

FJR70_01510

aspartate kinase [KO:K00928] [EC:2.7.2.4]

FJR70_12385

dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]

FJR70_12390

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

FJR70_21165

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

FJR70_06210

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

FJR70_09755

homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

FJR70_21170

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

FJR70_17505

homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

FJR70_15070

metI; cystathionine gamma-synthase/O-acetylhomoserine thiolyase [KO:K01739] [EC:2.5.1.48]

FJR70_21175

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase [KO:K01740] [EC:2.5.1.49]

FJR70_29235

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

FJR70_01690

ilvE; branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]

FJR70_06325

cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]

FJR70_00455

aspB; aspartate transaminase AspB [KO:K00812] [EC:2.6.1.1]

FJR70_00595

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

FJR70_02050

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

FJR70_18325

L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

FJR70_17635

amino acid racemase [KO:K25316] [EC:5.1.1.10]

FJR70_03140

D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]

FJR70_16695

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

FJR70_14455

sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]

FJR70_14460

sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta [KO:K01752] [EC:4.3.1.17]

FJR70_02965

3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

FJR70_02960

serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]

FJR70_30745

cysteine synthase family protein [KO:K22847] [EC:2.8.5.1]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors