KEGG   PATHWAY: bub00260
Entry
bub00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia ubonensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bub00260  Glycine, serine and threonine metabolism
bub00260

Module
bub_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bub00260]
bub_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bub00260]
bub_M00555  Betaine biosynthesis, choline => betaine [PATH:bub00260]
bub_M00621  Glycine cleavage system [PATH:bub00260]
bub_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bub00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia ubonensis [GN:bub]
Gene
BW23_2908  aspartate kinase domain protein [KO:K00928] [EC:2.7.2.4]
BW23_4715  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BW23_3138  ACT domain protein [KO:K00003] [EC:1.1.1.3]
BW23_5282  homoserine dehydrogenase, NAD binding domain protein [KO:K00003] [EC:1.1.1.3]
BW23_4634  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BW23_3139  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BW23_3857  beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]
BW23_935  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
BW23_3480  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
BW23_5961  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BW23_1925  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BW23_627  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BW23_3253  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BW23_3064  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
BW23_2027  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BW23_1050  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
BW23_1751  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BW23_692  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BW23_3207  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BW23_936  short chain dehydrogenase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BW23_4022  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BW23_4023  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BW23_6145  pyridine nucleotide-disulfide oxidoreductase family protein [KO:K00274] [EC:1.4.3.4]
BW23_6156  FAD dependent oxidoreductase family protein [KO:K00274] [EC:1.4.3.4]
BW23_1570  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BW23_1568  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BW23_237  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BW23_2781  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BW23_5911  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BW23_1569  gcvH; glycine cleavage system H protein [KO:K02437]
BW23_5509  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BW23_2601  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BW23_3496  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BW23_3495  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BW23_3473  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
BW23_3472  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
BW23_3477  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
BW23_3476  4Fe-4S dicluster domain protein [KO:K21834]
BW23_3475  electron transfer flavoFAD-binding domain protein [KO:K25960]
BW23_3474  electron transfer flavodomain protein [KO:K25961]
BW23_3595  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BW23_3597  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BW23_3594  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BW23_3596  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BW23_5276  beta-eliminating lyase family protein [KO:K01758] [EC:4.4.1.1]
BW23_3598  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BW23_1572  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BW23_2158  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BW23_3039  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
BW23_482  pyridoxal-phosphate dependent enzyme family protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
BW23_2153  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
BW23_2773  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
BW23_4722  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BW23_4720  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BW23_5770  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bub00010  Glycolysis / Gluconeogenesis
bub00020  Citrate cycle (TCA cycle)
bub00230  Purine metabolism
bub00250  Alanine, aspartate and glutamate metabolism
bub00270  Cysteine and methionine metabolism
bub00290  Valine, leucine and isoleucine biosynthesis
bub00300  Lysine biosynthesis
bub00330  Arginine and proline metabolism
bub00460  Cyanoamino acid metabolism
bub00470  D-Amino acid metabolism
bub00564  Glycerophospholipid metabolism
bub00600  Sphingolipid metabolism
bub00620  Pyruvate metabolism
bub00630  Glyoxylate and dicarboxylate metabolism
bub00640  Propanoate metabolism
bub00680  Methane metabolism
bub00860  Porphyrin metabolism
bub00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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