KEGG   PATHWAY: ccad00260
Entry
ccad00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cervus canadensis (wapiti)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ccad00260  Glycine, serine and threonine metabolism
ccad00260

Module
ccad_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ccad00260]
ccad_M00047  Creatine pathway [PATH:ccad00260]
ccad_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ccad00260]
ccad_M00555  Betaine biosynthesis, choline => betaine [PATH:ccad00260]
ccad_M00621  Glycine cleavage system [PATH:ccad00260]
ccad_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ccad00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122437619  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
122444022  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
122427446  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
122428409  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122452886  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122424877  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
122424511  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
122446075  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
122438665  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122435337  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122453185  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
122432795  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
122423453  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
122452921  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
122424282  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
122435874  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
122435330  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
122434832  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
122441340  primary amine oxidase, liver isozyme isoform X1 [KO:K00276] [EC:1.4.3.21]
122441363  primary amine oxidase, lung isozyme-like isoform X1 [KO:K00276] [EC:1.4.3.21]
122441372  AOC3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
122441377  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
122453186  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
122424959  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
122438319  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122448859  glycine cleavage system H protein, mitochondrial [KO:K02437]
122420997  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
122438399  glycine cleavage system H protein, mitochondrial [KO:K02437]
122441536  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122449970  glycine cleavage system H protein, mitochondrial [KO:K02437]
122452036  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122452278  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122453243  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122434906  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122434914  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122427182  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122428645  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
122422138  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
122454584  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122443646  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122439961  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
122424657  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
122440104  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122423739  LOW QUALITY PROTEIN: alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122443008  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122443005  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
122448308  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
122442336  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
122429153  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
122445387  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
122436832  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
122423051  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122423058  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122447534  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ccad00010  Glycolysis / Gluconeogenesis
ccad00020  Citrate cycle (TCA cycle)
ccad00230  Purine metabolism
ccad00250  Alanine, aspartate and glutamate metabolism
ccad00270  Cysteine and methionine metabolism
ccad00290  Valine, leucine and isoleucine biosynthesis
ccad00330  Arginine and proline metabolism
ccad00470  D-Amino acid metabolism
ccad00564  Glycerophospholipid metabolism
ccad00600  Sphingolipid metabolism
ccad00620  Pyruvate metabolism
ccad00630  Glyoxylate and dicarboxylate metabolism
ccad00640  Propanoate metabolism
ccad00860  Porphyrin metabolism
ccad00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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