KEGG   PATHWAY: ccaj00270
Entry
ccaj00270                   Pathway                                
Name
Cysteine and methionine metabolism - Cajanus cajan (pigeon pea)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
ccaj00270  Cysteine and methionine metabolism
ccaj00270

Module
ccaj_M00021  Cysteine biosynthesis, serine => cysteine [PATH:ccaj00270]
ccaj_M00034  Methionine salvage pathway [PATH:ccaj00270]
ccaj_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:ccaj00270]
Other DBs
GO: 0006534 0006555
Organism
Cajanus cajan (pigeon pea) [GN:ccaj]
Gene
109798522  serine acetyltransferase 4 isoform X1 [KO:K00640] [EC:2.3.1.30]
109808317  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
109788142  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
109788323  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
109800881  serine acetyltransferase 2 isoform X1 [KO:K00640] [EC:2.3.1.30]
109808446  cysteine synthase [KO:K01738] [EC:2.5.1.47]
109815582  cysteine synthase, chloroplastic/chromoplastic [KO:K01738] [EC:2.5.1.47]
109803639  cysteine synthase [KO:K01738] [EC:2.5.1.47]
109787939  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
109794291  cysteine synthase isoform X2 [KO:K01738] [EC:2.5.1.47]
109792332  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
109792315  cysteine synthase [KO:K01738] [EC:2.5.1.47]
109792795  cysteine synthase [KO:K01738] [EC:2.5.1.47]
109802499  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
109815629  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
109816129  homocysteine S-methyltransferase 3 isoform X1 [KO:K00547] [EC:2.1.1.10]
109791432  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
109815852  selenocysteine methyltransferase [KO:K00547] [EC:2.1.1.10]
109819184  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
109805702  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 isoform X1 [KO:K00549] [EC:2.1.1.14]
109808534  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
109808944  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
109808462  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109796585  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109788308  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
109792056  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
109796681  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
109796779  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
109805762  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
109809289  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
109803526  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
109795188  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
109791274  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
109808954  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
109800281  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
109819327  spermidine synthase 2 isoform X2 [KO:K00797] [EC:2.5.1.16]
109809064  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
109797457  spermine synthase [KO:K00797] [EC:2.5.1.16]
109790589  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
109797885  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
109806164  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
109801994  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2 isoform X1 [KO:K01244] [EC:3.2.2.16]
109801996  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1 [KO:K01244] [EC:3.2.2.16]
109816469  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
109790684  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
109817466  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
109805886  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
109812913  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
109806351  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
109815770  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
109809304  uncharacterized protein LOC109809304 [KO:K23977] [EC:2.6.1.117]
109817949  uncharacterized protein LOC109817949 isoform X1 [KO:K23977] [EC:2.6.1.117]
109817239  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
109788742  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
109805483  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
109790676  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
109794388  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
109800177  putative DNA (cytosine-5)-methyltransferase CMT1 isoform X1 [KO:K00558] [EC:2.1.1.37]
109818501  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
109808733  DNA (cytosine-5)-methyltransferase CMT2 isoform X1 [KO:K00558] [EC:2.1.1.37]
109803924  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
109796175  uncharacterized protein LOC109796175 [KO:K17398] [EC:2.1.1.37]
109807320  adenosylhomocysteinase 1 [KO:K01251] [EC:3.13.2.1]
109807882  adenosylhomocysteinase isoform X1 [KO:K01251] [EC:3.13.2.1]
109800648  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
109799512  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
109803088  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
109805792  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
109810552  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
109818867  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
109799665  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
109792173  1-aminocyclopropane-1-carboxylate synthase 3 isoform X1 [KO:K01762] [EC:4.4.1.14]
109796318  1-aminocyclopropane-1-carboxylate synthase 9 [KO:K01762] [EC:4.4.1.14]
109817071  1-aminocyclopropane-1-carboxylate oxidase 4 [KO:K05933] [EC:1.14.17.4]
109804404  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
109808078  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
109799389  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
109803578  1-aminocyclopropane-1-carboxylate oxidase 4 [KO:K05933] [EC:1.14.17.4]
109793755  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
109817981  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
109818885  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
109797540  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
109814628  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
109807968  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109807745  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
109803603  uncharacterized protein LOC109803603 [KO:K00133] [EC:1.2.1.11]
109802197  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
109809943  branched-chain amino acid aminotransferase 1, mitochondrial [KO:K00826] [EC:2.6.1.42]
109808771  putative branched-chain-amino-acid aminotransferase 7 [KO:K00826] [EC:2.6.1.42]
109797063  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
109809718  putative branched-chain-amino-acid aminotransferase 7 [KO:K00826] [EC:2.6.1.42]
109792171  branched-chain amino acid aminotransferase 2, chloroplastic isoform X2 [KO:K00826] [EC:2.6.1.42]
109813650  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109816349  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109816350  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109801602  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109800112  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109789082  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
109816165  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
109796437  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109797327  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109797450  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109800915  aspartate aminotransferase 1 [KO:K14454] [EC:2.6.1.1]
109814125  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
109799344  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
109815346  aspartate aminotransferase P2, mitochondrial [KO:K00811] [EC:2.6.1.1]
109818810  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial [KO:K01011] [EC:2.8.1.1 2.8.1.2]
109801439  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
109808619  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
109799609  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
109799338  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
109794318  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
109807724  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
109797560  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
109805010  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
109788860  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
109805832  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
109809274  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
109809827  malate dehydrogenase 2, peroxisomal [KO:K00026] [EC:1.1.1.37]
109801047  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
109802057  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic [KO:K22846] [EC:2.5.1.144]
109795032  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109812684  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109807040  D-3-phosphoglycerate dehydrogenase 2, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109801192  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
109798642  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
ccaj00010  Glycolysis / Gluconeogenesis
ccaj00250  Alanine, aspartate and glutamate metabolism
ccaj00260  Glycine, serine and threonine metabolism
ccaj00290  Valine, leucine and isoleucine biosynthesis
ccaj00430  Taurine and hypotaurine metabolism
ccaj00480  Glutathione metabolism
ccaj00620  Pyruvate metabolism
ccaj00640  Propanoate metabolism
ccaj00770  Pantothenate and CoA biosynthesis
ccaj00900  Terpenoid backbone biosynthesis
ccaj00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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