KEGG   PATHWAY: ccri00600
Entry
ccri00600                   Pathway                                
Name
Sphingolipid metabolism - Cariama cristata (Red-legged seriema)
Class
Metabolism; Lipid metabolism
Pathway map
ccri00600  Sphingolipid metabolism
ccri00600

Module
ccri_M00066  Lactosylceramide biosynthesis [PATH:ccri00600]
ccri_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:ccri00600]
ccri_M00094  Ceramide biosynthesis [PATH:ccri00600]
ccri_M00099  Sphingosine biosynthesis [PATH:ccri00600]
Other DBs
GO: 0006665
Organism
Cariama cristata (Red-legged seriema) [GN:ccri]
Gene
104169004  SPTLC3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
104166928  SPTLC2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
104159395  KDSR; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
104157429  CERS1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
104159440  ceramide synthase 4-like [KO:K24621] [EC:2.3.1.297]
104163289  CERS3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
104161428  LOW QUALITY PROTEIN: ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
104162691  CERS5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
104167847  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
104160044  ASAH2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
104167146  ACER2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
104163941  ACER1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
104162758  ACER3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
104164939  DEGS2; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
104168857  DEGS1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
104164592  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
104165830  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
104157635  SMPD3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
104167954  SMPD4; sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
104156279  ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
104160159  CERK; ceramide kinase [KO:K04715] [EC:2.7.1.138]
104168819  LOW QUALITY PROTEIN: lipid phosphate phosphohydrolase 2-like [KO:K01080] [EC:3.1.3.4]
104158358  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
104154487  lipid phosphate phosphohydrolase 1-like [KO:K01080] [EC:3.1.3.4]
104166051  SGPL1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
104169341  UGCG; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
104154948  GBA2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
104162913  B4GALT5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
104165429  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
104160879  2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
104161821  UGT8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
104165255  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
104168858  GAL3ST1; galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
104157054  LOW QUALITY PROTEIN: arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
104164579  NEU2; sialidase-2 [KO:K12357] [EC:3.2.1.18]
104163898  NEU4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
104160223  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
104167081  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
104163943  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
104160910  GM2A; ganglioside GM2 activator [KO:K12383]
104158820  PSAP; prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
ccri00260  Glycine, serine and threonine metabolism
ccri00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ccri00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ccri00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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