KEGG PATHWAY: cgob00760

KEGG

PATHWAY: cgob00760

Entry

cgob00760                   Pathway

Name

Nicotinate and nicotinamide metabolism - Cottoperca gobio

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Nicotinate and nicotinamide metabolism

Module

NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:cgob00760]

Other DBs

UMBBD:

GO:	0046497 0006769

Organism

Cottoperca gobio [GN:cgob]

Gene

aspdh; putative L-aspartate dehydrogenase [KO:K06989] [EC:1.4.1.21]

qprt; nicotinate-nucleotide pyrophosphorylase [carboxylating] [KO:K00767] [EC:2.4.2.19]

naprt; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]

purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]

purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]

purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]

purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]

purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]

nicotinamide riboside kinase 2-like isoform X1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]

nicotinamide riboside kinase 2-like isoform X1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]

nicotinamide riboside kinase 1-like [KO:K10524] [EC:2.7.1.22 2.7.1.173]

nicotinamide riboside kinase 2-like isoform X1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]

nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]

nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]

cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]

cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]

cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]

cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]

cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]

cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]

cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]

5'-nucleotidase-like [KO:K19970] [EC:3.1.3.5]

LOW QUALITY PROTEIN: 5'-nucleotidase-like [KO:K19970] [EC:3.1.3.5]

nmnat2; LOW QUALITY PROTEIN: nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

nmnat3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

nmnat1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

venom phosphodiesterase 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]

ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]

nudt12; peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]

nadsyn1; glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]

nicotinamide phosphoribosyltransferase-like isoform X1 [KO:K03462] [EC:2.4.2.12]

nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]

LOW QUALITY PROTEIN: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]

sarm1; sterile alpha and TIR motif-containing protein 1 [KO:K27536] [EC:3.2.2.6]

sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]

sirt2; NAD-dependent protein deacetylase sirtuin-2 [KO:K11412] [EC:2.3.1.286]

sirt3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1 [KO:K11413] [EC:2.3.1.286]

LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-3-like [KO:K11413] [EC:2.3.1.286]

sirt4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial [KO:K11414] [EC:2.3.1.286 2.3.1.313]

LOW QUALITY PROTEIN: NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [KO:K11415] [EC:2.3.1.286]

NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [KO:K11415] [EC:2.3.1.286]

sirt6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]

sirt7; NAD-dependent protein deacetylase sirtuin-7 isoform X1 [KO:K11417] [EC:2.3.1.286]

NAD kinase-like [KO:K00858] [EC:2.7.1.23]

nadk; NAD kinase isoform X1 [KO:K00858] [EC:2.7.1.23]

NAD(P) transhydrogenase, mitochondrial-like [KO:K00323] [EC:7.1.1.1]

LOW QUALITY PROTEIN: NAD(P) transhydrogenase, mitochondrial-like [KO:K00323] [EC:7.1.1.1]

LOW QUALITY PROTEIN: aldehyde oxidase 1-like [KO:K00157] [EC:1.2.3.1]

LOW QUALITY PROTEIN: aldehyde oxidase 1-like [KO:K00157] [EC:1.2.3.1]

Compound

NAD+

NADP+

Pyruvate

Succinate

L-Aspartate

Glycerone phosphate

Fumarate

Nicotinamide

Propanoate

Succinate semialdehyde

Nicotinate

4-Aminobutanoate

Nicotinamide D-ribonucleotide

Nicotine

Deamino-NAD+

2,3-Dimethylmaleate

6-Hydroxynicotinate

(S)-6-Hydroxynicotine

2,5-Dihydroxypyridine

Nicotinate D-ribonucleotide

6-Hydroxypseudooxynicotine

Maleic acid

Maleamate

Methylitaconate

1-Methylnicotinamide

2-Methyleneglutarate

(R)-6-Hydroxynicotine

2,6-Dihydroxypyridine

Nicotinamide-beta-riboside

2,3,6-Trihydroxypyridine

(2R,3S)-2,3-Dimethylmalate

Quinolinate

6-Oxo-1,4,5,6-tetrahydronicotinate

Nicotinurate

Iminoaspartate

Nicotinate D-ribonucleoside

N1-Methyl-2-pyridone-5-carboxamide

N1-Methyl-4-pyridone-5-carboxamide

1-Methylpyrrolinium

2,6-Dihydroxynicotinate

2,6-Dihydroxypseudooxynicotine

4-Methylaminobutyrate

2,6-Dihydroxy-N-methylmyosmine

Blue pigment

2-Formylglutarate

(R)-Nicotine

(S)-2-(Hydroxymethyl)glutarate

N-Formylmaleamic acid

4-Oxo-1-(3-pyridyl)-1-butanone

3-Succinoylpyridine

6-Hydroxy-3-succinoylpyridine

Pseudooxynicotine

3,3'-Bipyridine-2,2',5,5',6,6'-hexol

5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol

N-Methylmyosmine

Reference

Authors

BEHRMAN EJ, STANIER RY.

Title

The bacterial oxidation of nicotinic acid.

Journal

J Biol Chem 228:923-45 (1957)

Reference

Authors

Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.

Title

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.

Journal

Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103

Reference

Authors

Baitsch D, Sandu C, Brandsch R, Igloi GL.

Title

Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.

Journal

J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001

Reference

Authors

Sachelaru P, Schiltz E, Igloi GL, Brandsch R.

Title

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.

Journal

J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005

Reference

Authors

Gherna RL, Richardson SH, Rittenberg SC

Title

The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.

Journal

J Biol Chem 240:3669-74 (1965)

Reference

Authors

Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N

Title

Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.

Journal

J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818

Related
pathway

Citrate cycle (TCA cycle)

Alanine, aspartate and glutamate metabolism

Tryptophan metabolism

Pyruvate metabolism

KO pathway

LinkDB

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