KEGG   PATHWAY: clud00260
Entry
clud00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Canis lupus dingo (dingo)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
clud00260  Glycine, serine and threonine metabolism
clud00260

Module
clud_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:clud00260]
clud_M00047  Creatine pathway [PATH:clud00260]
clud_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:clud00260]
clud_M00555  Betaine biosynthesis, choline => betaine [PATH:clud00260]
clud_M00621  Glycine cleavage system [PATH:clud00260]
clud_M00974  Betaine metabolism, animals, betaine => glycine [PATH:clud00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112672872  uncharacterized protein LOC112672872 isoform X2 [KO:K01620] [EC:4.1.2.48]
112677986  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
112647265  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
112670025  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
112650245  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
112672135  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
112650593  PGAM2; phosphoglycerate mutase 2 isoform X1 [KO:K01834] [EC:5.4.2.11]
112670467  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
112664089  D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112664099  D-3-phosphoglycerate dehydrogenase-like isoform X2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112664106  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
112644681  phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
112646076  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
112668292  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
112669652  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
112673052  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
112665874  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
112673161  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
112673162  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125752077  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
112655649  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
112655648  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
112649862  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
112667393  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
112665781  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
112661300  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
112646709  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
112676720  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
112652638  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
112675997  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
112666184  GAMT; guanidinoacetate N-methyltransferase isoform X2 [KO:K00542] [EC:2.1.1.2]
112665921  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
112649908  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
112653426  BHMT; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
112653283  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
112677643  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
112677395  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
112641604  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
112651104  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
112641069  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
112676596  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
112676597  SDSL; serine dehydratase-like isoform X3 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
112677551  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
clud00010  Glycolysis / Gluconeogenesis
clud00020  Citrate cycle (TCA cycle)
clud00230  Purine metabolism
clud00250  Alanine, aspartate and glutamate metabolism
clud00270  Cysteine and methionine metabolism
clud00290  Valine, leucine and isoleucine biosynthesis
clud00330  Arginine and proline metabolism
clud00470  D-Amino acid metabolism
clud00564  Glycerophospholipid metabolism
clud00600  Sphingolipid metabolism
clud00620  Pyruvate metabolism
clud00630  Glyoxylate and dicarboxylate metabolism
clud00640  Propanoate metabolism
clud00860  Porphyrin metabolism
clud00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system