KEGG   PATHWAY: crg00600
Entry
crg00600                    Pathway                                
Name
Sphingolipid metabolism - Magallana gigas (Pacific oyster)
Class
Metabolism; Lipid metabolism
Pathway map
crg00600  Sphingolipid metabolism
crg00600

Module
crg_M00094  Ceramide biosynthesis [PATH:crg00600]
crg_M00099  Sphingosine biosynthesis [PATH:crg00600]
crg_M00100  Sphingosine degradation [PATH:crg00600]
Other DBs
GO: 0006665
Organism
Magallana gigas (Pacific oyster) [GN:crg]
Gene
105318166  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
105324314  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
105330505  serine palmitoyltransferase 2 isoform X2 [KO:K00654] [EC:2.3.1.50]
105318204  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
105344976  3-ketodihydrosphingosine reductase-like precursor [KO:K04708] [EC:1.1.1.102]
105335972  ceramide synthase 2 [KO:K23727] [EC:2.3.1.291]
117683888  ceramide synthase 6-like isoform X1 [KO:K23727] [EC:2.3.1.291]
105332957  ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
105334663  acid ceramidase-like precursor [KO:K12348] [EC:3.5.1.23]
105347438  neutral ceramidase [KO:K12349] [EC:3.5.1.23]
105331686  alkaline ceramidase 3 isoform X1 [KO:K04711] [EC:3.5.1.-]
117690257  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
105320205  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
105325194  sphingolipid delta(4)-desaturase DES1-like isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
105348190  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
105337420  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
105324916  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
105322453  ceramide kinase [KO:K04715] [EC:2.7.1.138]
105343295  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
105343296  ceramide kinase-like protein isoform X2 [KO:K04715] [EC:2.7.1.138]
105334232  sphingosine kinase 2 isoform X1 [KO:K04715] [EC:2.7.1.138]
105321802  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
105344779  ceramide kinase [KO:K04715] [EC:2.7.1.138]
117689200  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
109619194  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
105342753  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
105345617  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
105327580  phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105339798  phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105345621  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
105320597  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
105333032  sphingosine-1-phosphate phosphatase 2 [KO:K04716] [EC:3.1.3.-]
105334190  sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04716] [EC:3.1.3.-]
105341300  ceramide phosphoethanolamine synthase isoform X1 [KO:K26283] [EC:2.7.8.48]
105343802  sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105325808  sphingosine-1-phosphate lyase isoform X1 [KO:K01634] [EC:4.1.2.27]
105338792  sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
105332650  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
105335430  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
105349057  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
105343267  lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
105326285  non-lysosomal glucosylceramidase-like isoform X1 [KO:K17108] [EC:3.2.1.45]
105340763  beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
105334333  galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
105326196  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
105338589  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
105341335  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
105320156  beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
105325215  putative beta-hexosaminidase [KO:K12373] [EC:3.2.1.52]
105325216  putative beta-hexosaminidase [KO:K12373] [EC:3.2.1.52]
105331402  beta-hexosaminidase [KO:K12373] [EC:3.2.1.52]
105346729  beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
105343585  beta-hexosaminidase subunit alpha isoform X3 [KO:K12373] [EC:3.2.1.52]
105332068  chitobiase [KO:K12373] [EC:3.2.1.52]
105327085  beta-hexosaminidase-like [KO:K12373] [EC:3.2.1.52]
117687051  beta-hexosaminidase-like isoform X1 [KO:K12373] [EC:3.2.1.52]
105320220  beta-hexosaminidase [KO:K12373] [EC:3.2.1.52]
117688100  beta-hexosaminidase-like isoform X1 [KO:K12373] [EC:3.2.1.52]
105324557  beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
105348455  beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
105324935  chitobiase [KO:K12373] [EC:3.2.1.52]
105318146  ganglioside GM2 activator [KO:K12383]
105330041  ganglioside GM2 activator [KO:K12383]
105346017  ganglioside GM2 activator [KO:K12383]
105346018  ganglioside GM2 activator-like [KO:K12383]
105346019  ganglioside GM2 activator [KO:K12383]
105346653  ganglioside GM2 activator [KO:K12383]
105348613  ganglioside GM2 activator-like isoform X1 [KO:K12383]
105320698  ganglioside GM2 activator isoform X1 [KO:K12383]
105330237  ganglioside GM2 activator [KO:K12383]
105323362  ganglioside GM2 activator-like [KO:K12383]
117690737  ganglioside GM2 activator-like [KO:K12383]
105340758  uncharacterized protein LOC105340758 isoform X2 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
crg00260  Glycine, serine and threonine metabolism
crg00601  Glycosphingolipid biosynthesis - lacto and neolacto series
crg00603  Glycosphingolipid biosynthesis - globo and isoglobo series
crg00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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