KEGG   PATHWAY: csai00270
Entry
csai00270                   Pathway                                
Name
Cysteine and methionine metabolism - Cololabis saira (Pacific saury)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
csai00270  Cysteine and methionine metabolism
csai00270

Module
csai_M00034  Methionine salvage pathway [PATH:csai00270]
csai_M00035  Methionine degradation [PATH:csai00270]
csai_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:csai00270]
Other DBs
GO: 0006534 0006555
Organism
Cololabis saira (Pacific saury) [GN:csai]
Gene
133458491  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
133458048  kynurenine--oxoglutarate transaminase 3-like isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
133454987  kyat1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
133445564  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
133425040  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
133454611  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
133450647  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
133450648  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
133458077  uncharacterized protein zgc:172121 [KO:K00547] [EC:2.1.1.10]
133419297  mtr; methionine synthase [KO:K00548] [EC:2.1.1.13]
133460020  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
133419320  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
133454595  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
133455045  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
133455285  mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
133450511  mat2ab; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
133463640  mat1a; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
133464369  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
133456513  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
133459542  sms; spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
133437049  mtap; S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
133446376  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
133443070  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
133458775  apip; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
133454596  enolase-phosphatase E1-like [KO:K09880] [EC:3.1.3.77]
133455048  enolase-phosphatase E1-like [KO:K09880] [EC:3.1.3.77]
133461957  adi1; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
133443932  tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
133420292  L-amino-acid oxidase-like isoform X1 [KO:K03334] [EC:1.4.3.2]
133420404  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
133420938  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
133420939  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
133442223  il4i1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
133462264  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
133421486  dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
133464704  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
133462782  dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
133456725  uncharacterized protein LOC133456725 isoform X1 [KO:K17399] [EC:2.1.1.37]
133456865  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
133456866  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
133444363  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
133424513  ahcyl2b; adenosylhomocysteinase like 2b isoform X1 [KO:K01251] [EC:3.13.2.1]
133448259  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
133448496  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
133457252  ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
133424488  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
133422658  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]
133454923  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
133454924  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
133463706  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
133458385  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
133457496  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
133450643  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
133463893  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
133448833  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
133462668  got2b; glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
133452294  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
133421562  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
133421744  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
133423889  ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
133443789  L-lactate dehydrogenase B-A chain-like isoform X1 [KO:K00016] [EC:1.1.1.27]
133444038  ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
133446520  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
133463342  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
133426282  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
133450317  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
133462266  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
133462935  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
133446449  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
133451143  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
csai00010  Glycolysis / Gluconeogenesis
csai00250  Alanine, aspartate and glutamate metabolism
csai00260  Glycine, serine and threonine metabolism
csai00290  Valine, leucine and isoleucine biosynthesis
csai00430  Taurine and hypotaurine metabolism
csai00480  Glutathione metabolism
csai00620  Pyruvate metabolism
csai00640  Propanoate metabolism
csai00770  Pantothenate and CoA biosynthesis
csai00900  Terpenoid backbone biosynthesis
csai00920  Sulfur metabolism
KO pathway
ko00270   
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