KEGG   PATHWAY: dnm05332
Entry
dnm05332                    Pathway                                
Name
Graft-versus-host disease - Dasypus novemcinctus (nine-banded armadillo)
Description
Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.
Class
Human Diseases; Immune disease
Pathway map
dnm05332  Graft-versus-host disease
dnm05332

Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101429481  LOW QUALITY PROTEIN: interleukin-6-like [KO:K05405]
101443963  IL6; interleukin-6 [KO:K05405]
101441434  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101445167  IL1B; interleukin-1 beta [KO:K04519]
101420445  TNF; tumor necrosis factor [KO:K03156]
101415145  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101437028  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101443412  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101438478  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101440773  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
101433781  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101435501  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
101435917  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
101436345  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
101437751  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
101415573  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X1 [KO:K06752]
101417015  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
101417743  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
101421271  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101421706  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101423192  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
101412832  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
101415501  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
101413757  IL2; interleukin-2 precursor [KO:K05429]
101428513  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
101420800  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101415823  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101418741  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101446223  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101415391  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
101439136  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101439564  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101435448  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
111758663  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101430252  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
101444704  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101426756  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101438484  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101411165  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101427038  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
101412608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101447227  HLA class I histocompatibility antigen, Cw-14 alpha chain-like [KO:K06751]
101442840  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101411454  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101413764  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415824  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105744147  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101441690  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101444673  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101428809  HLA class I histocompatibility antigen, B-59 alpha chain-like [KO:K06751]
101412139  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442557  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101432742  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101437850  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
101422560  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101427325  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101445227  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101421532  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101424781  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101430113  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101435675  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X2 [KO:K06751]
101419419  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
101442251  HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751]
101439095  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101411831  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
101422917  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101412902  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101422259  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101412468  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101414493  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
101442691  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101432034  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101424334  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415212  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442654  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
101417353  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101413233  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101411103  PRF1; perforin-1 [KO:K07818]
101411550  perforin-1 [KO:K07818]
101422721  granzyme H [KO:K01353] [EC:3.4.21.79]
101419645  granzyme H-like [KO:K01353] [EC:3.4.21.79]
101426115  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
101422877  IFNG; interferon gamma [KO:K04687]
101429122  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101434090  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101413140  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101424698  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
101425586  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
101427070  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101429553  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
101436645  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101438360  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101431999  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
101421021  natural killer cells antigen CD94 isoform X1 [KO:K06516]
101422351  natural killer cells antigen CD94-like isoform X3 [KO:K06516]
101428380  natural killer cells antigen CD94-like [KO:K06516]
101414445  natural killer cells antigen CD94-like [KO:K06516]
101431573  natural killer cells antigen CD94-like [KO:K06516]
Compound
C00338  Lipopolysaccharide
C00533  Nitric oxide
Reference
PMID:16412784
  Authors
Ferrara JL, Reddy P.
  Title
Pathophysiology of graft-versus-host disease.
  Journal
Semin Hematol 43:3-10 (2006)
DOI:10.1053/j.seminhematol.2005.09.001
Reference
PMID:14735553
  Authors
Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease.
  Journal
Hematol Oncol 21:149-61 (2003)
DOI:10.1002/hon.716
Reference
PMID:17900507
  Authors
Sun Y, Tawara I, Toubai T, Reddy P.
  Title
Pathophysiology of acute graft-versus-host disease: recent advances.
  Journal
Transl Res 150:197-214 (2007)
DOI:10.1016/j.trsl.2007.06.003
Reference
PMID:15882431
  Authors
Jaksch M, Mattsson J.
  Title
The pathophysiology of acute graft-versus-host disease.
  Journal
Scand J Immunol 61:398-409 (2005)
DOI:10.1111/j.1365-3083.2005.01595.x
Reference
PMID:12359826
  Authors
Vogelsang GB, Lee L, Bensen-Kennedy DM.
  Title
Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.
  Journal
Annu Rev Med 54:29-52 (2003)
DOI:10.1146/annurev.med.54.101601.152339
Reference
PMID:14556773
  Authors
Reddy P, Ferrara JL.
  Title
Immunobiology of acute graft-versus-host disease.
  Journal
Blood Rev 17:187-94 (2003)
DOI:10.1016/S0268-960X(03)00009-2
Reference
PMID:16147539
  Authors
Blazar BR, Murphy WJ.
  Title
Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).
  Journal
Philos Trans R Soc Lond B Biol Sci 360:1747-67 (2005)
DOI:10.1098/rstb.2005.1701
Reference
PMID:15372473
  Authors
Couriel D, Caldera H, Champlin R, Komanduri K.
  Title
Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.
  Journal
Cancer 101:1936-46 (2004)
DOI:10.1002/cncr.20613
Reference
PMID:17784964
  Authors
Jacobsohn DA, Vogelsang GB.
  Title
Acute graft versus host disease.
  Journal
Orphanet J Rare Dis 2:35 (2007)
DOI:10.1186/1750-1172-2-35
Related
pathway
dnm04060  Cytokine-cytokine receptor interaction
dnm04210  Apoptosis
dnm04514  Cell adhesion molecules
dnm04612  Antigen processing and presentation
dnm04620  Toll-like receptor signaling pathway
dnm04650  Natural killer cell mediated cytotoxicity
dnm04660  T cell receptor signaling pathway
KO pathway
ko05332   
LinkDB

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